Publications with Seahorse XF Data

Aging

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• Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice

  Jackson K C, Wohlers L M, Lovering R M, Schuh R A, Maher A C, Bonen A, Koves T R, Ilkayeva O, Thomson D M, Muoio D M and Spangenburg E E

  Am J Physiol Regul Integr Comp Physiol; 2013 Feb 1.

• Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging

  Horan M P, Pichaud N and Ballard J W

  J Gerontol A Biol Sci Med Sci; 2012 Oct 1. 67 (10):1022-35.

• GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence

  Byun H O, Jung H J, Seo Y H, Lee Y K, Hwang S C, Seong Hwang E and Yoon G

  Exp Cell Res; 2012 Sep 10. 318 (15):1808-19.

• ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

  Grunewald A, Arns B, Seibler P, Rakovic A, Munchau A, Ramirez A, Sue C M and Klein C

  Neurobiol Aging; 2012 Aug 1. 33 (8):1843.e.1-7.

• Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan

  Hung C-L, Wu Y-J, Liu C-C, Chi B-C, Chang S-S, Wang L-Y, Yeh H-I and Wei Y-H

  International Journal of Gerontology; 2012 Jun 8. 6 (2):122-126.

• Short-term calorie restriction enhances skeletal muscle stem cell function

  Cerletti M, Jang Y C, Finley L W, Haigis M C and Wagers A J

  Cell Stem Cell; 2012 May 4. 10 (5):515-519.

• Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

  Quijano C, Cao L, Fergusson M M, Romero H, Liu J, Gutkind S, Rovira, II, Mohney R P, Karoly E D and Finkel T

  Cell Cycle; 2012 Apr 1. 11 (7):1383-1392.

• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

  Park S J, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown A L, Kim M K, Beaven M A, Burgin A B, Manganiello V and Chung J H

  Cell; 2012 Feb 3. 148 (3):421-433.

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Bmi1 regulates mitochondrial function and the DNA damage response pathway

  Liu J, Cao L, Chen J, Song S, Lee I H, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L Y, Ahn B H, Kumar N G, Rovira, II, Xu X L, van Lohuizen M, Motoyama N, Deng C X and Finkel T

  Nature; 2009 May 21. 459 (7245):387-392.

• Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

  Wu J J, Quijano C, Chen E, Liu H, Cao L, Fergusson M M, Rovira, II, Gutkind S, Daniels M P, Komatsu M and Finkel T

  Aging (Albany NY); 2009 Apr 1. 1 (4):425-437.

Cancer

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• p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

  Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsasser H P and Stiewe T

  Cell reports. 2013 May 8; [Epub ahead of print].

• Arsenic exposure induces the Warburg effect in cultured human cells

  Zhao F, Severson P, Pacheco S, Futscher B W and Klimecki W T

  Toxicol Appl Pharmacol. 2013 May 4; [Epub ahead of print].

• Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

  Strickertsson J A, Desler C, Martin-Bertelsen T, Machado A M, Wadstrom T, Winther O, Rasmussen L J and Friis-Hansen L

  PloS one; 2013 Apr 30. 8 (4):e63147.

• Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

  Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee M J, Lee S, Vartholomaiou E, Tatokoro M, Beebe K, Miyajima N, Mohney R P, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K, Trepel J, Picard D and Neckers L

  Proc Natl Acad Sci U S A. 2013 Apr 5; [Epub ahead of print].

• Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

  Jeso V, Yang C, Cameron M D, Cleveland J L and Micalizio G C

  ACS Chem Biol. 2013 Apr 2; [Epub ahead of print].

• Mitochondria-Targeted Nitroxide, Mito-CP, Suppresses Medullary Thyroid Carcinoma Cell Survival in Vitro and in Vivo

  Starenki D and Park J I

  J Clin Endocrinol Metab; 2013 Apr 1. 98 (4):1529-40.

• Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

  Hall A, Meyle K D, Lange M K, Klima M, Sanderhoff M, Dahl C, Abildgaard C, Thorup K, Moghimi S M, Jensen P B, Bartek J, Guldberg P and Christensen C

  Oncotarget; 2013 Apr 1. 4 (4):584-599.

• Involvement of estrogen receptor beta5 in the progression of glioma

  Li W, Winters A, Poteet E, Ryou M G, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa K J, Simpkins J W and Yang S H

  Brain Res; 2013 Mar 29. 1503:97-107.

• Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

  Sanchez W Y, McGee S L, Connor T, Mottram B, Wilkinson A, Whitehead J P, Vuckovic S and Catley L

  Br J Cancer. 2013 Mar 26; [Epub ahead of print].

• Metabolic Changes During Ovarian Cancer Progression as Targets for Sphingosine Treatment

  Anderson A S, Roberts P C, Frisard M I, McMillan R P, Brown T J, Lawless M H, Hulver M W and Schmelz E M

  Exp Cell Res; 2013 Mar 19.

• Rab27B-Mediated Metabolic Reprogramming Induces Secretome Acidification and Chemoresistance in Breast Cancer Cells

  Hendrix A, Ciccone C, Gespach C, Bracke M, Wever O D and Westbroek W

  Exosomes and Microvesicles; 2013 Mar 18.

• Oncogenic BRAF Regulates Oxidative Metabolism via PGC1alpha and MITF

  Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe G C, Frederick D T, Hurley A D, Nellore A, Kung A L, Wargo J A, Song J S, Fisher D E, Arany Z and Widlund H R

  Cancer Cell; 2013 Mar 18. 23 (3):302-315.

• Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

  Shen Y-A, Hung P-H, Chi W-H, Wang C-Y, Hsieh Y-T, Wei Y H and Chen Y-J

  Evidence-Based Complementary and Alternative Medicine. 2013 Mar 16; [Epub ahead of print].

• Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma

  Kirstein M M, Boukouris A E, Pothiraju D, Buitrago-Molina L E, Marhenke S, Lamlé J, Orlik J, Kühnel F, Hegermann J, Manns M P and Vogel A

  Liver International. 2013 Mar 15; [Epub ahead of print].

• MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

  Grosso S, Doyen J, Parks S K, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noel A, Pouyssegur J, Barbry P, Mazure N M and Mari B

  Cell Death Dis; 2013 Mar 14. 4 (e544):2013.

• Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells

  Jhas B, Sriskanthadevan S, Skrtic M, Sukhai M A, Voisin V, Jitkova Y, Gronda M, Hurren R, Laister R C, Bader G D, Minden M D and Schimmer A D

  PLoS One; 2013 Mar 8. 8 (3):e58367.

• Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

  Parks S K, Mazure N M, Counillon L and Pouyssegur J

  J Cell Physiol. 2013 Mar 4; [Epub ahead of print].

• The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism

  Chu K, Boley K M, Moraes R, Barsky S H and Robertson F M

  Oncotarget; 2013 Mar 1. 4 (3):446-462.

• Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death

  Palorini R, Simonetto T, Cirulli C and Chiaradonna F

  International Journal of Cell Biology. 2013 Feb 28; [Epub ahead of print].

• Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria

  Suchorolski M T, Paulson T G, Sanchez C A, Hockenbery D and Reid B J

  PLoS One; 2013 Feb 27. 8 (2):e56884.

• The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the Numb-p53 Complex

  Feldman D E, Chen C, Punj V and Machida K

  PLoS One; 2013 Feb 27. 8 (2):e57312.

• Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

  Dong C, Yuan T, Wu Y, Wang Y, Fan T W, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung M C, Evers B M and Zhou B P

  Cancer Cell. 2013 Feb 27; [Epub ahead of print].

• An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

  Williams K J, Argus J P, Zhu Y, Wilks M Q, Marbois B N, York A G, Kidani Y, Pourzia A L, Akhavan D, Lisiero D N, Komisopoulou E, Henkin A H, Soto H, Chamberlain B T, Vergnes L, Jung M E, Torres J Z, Liau L M, Christofk H R, Prins R M, Mischel P S, Reue K, Graeber T G and Bensinger S

  Cancer Res; 2013 Feb 25.

• Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells

  Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q and Zhu D

  Cell Death Dis; 2013 Feb 14. 4 (e494):2013.

• Reversing the Warburg Effect as a Treatment for Glioblastoma

  Poteet E, Choudhury G R, Winters A, Li W, Ryou M G, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir S T, Yan H, Bigner D D, Simpkins J W and Yang S H

  J Biol Chem. 2013 Feb 13; [Epub ahead of print].

• PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

  Vazquez F, Lim J H, Chim H, Bhalla K, Girnun G, Pierce K, Clish C B, Granter S R, Widlund H R, Spiegelman B M and Puigserver P

  Cancer Cell. 2013 Feb 12; [Epub ahead of print].

• LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

  Shackelford D B, Abt E, Gerken L, Vasquez D S, Seki A, Leblanc M, Wei L, Fishbein M C, Czernin J, Mischel P S and Shaw R J

  Cancer Cell; 2013 Feb 11. 23 (2):143-58.

• Tracking metastasis and tricking cancer

  Marx V

  Nature; 2013 Feb 7. 494 (7435):133-136.

• The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

  Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P

  Oncogene; 2013 Feb 7. 32 (6):699-712.

• Metabolic changes in cancer cells upon suppression of MYC

  Anso E, Mullen A, Felsher D, Mates J, DeBerardinis R and Chandel N

  Cancer Metab; 2013 Feb 4. 1 (1):7.

• Role of p90RSK in regulating the Crabtree effect: implications for cancer

  Redman E K, Brookes P S and Karcz M K

  Biochem Soc Trans; 2013 Feb 1. 41 (1):124-126.

• Control of glutamine metabolism by the tumor suppressor Rb

  Reynolds M R, Lane A N, Robertson B, Kemp S, Liu Y, Hill B G, Dean D C and Clem B F

  Oncogene. 2013 Jan 28; [Epub ahead of print].

• Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

  Maddocks O D, Berkers C R, Mason S M, Zheng L, Blyth K, Gottlieb E and Vousden K H

  Nature; 2013 Jan 24.

• Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

  Griffiths B, Lewis C, Bensaad K, Ros S, Zhang Q, Ferber E, Konisti S, Peck B, Miess H, East P, Wakelam M, Harris A and Schulze A

  Cancer Metab; 2013 Jan 21. 1 (3)

• BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

  Lagadinou E D, Sach A, Callahan K, Rossi R M, Neering S J, Minhajuddin M, Ashton J M, Pei S, Grose V, O'Dwyer K M, Liesveld J L, Brookes P S, Becker M W and Jordan C T

  Cell Stem Cell. 2013 Jan 15; [Epub ahead of print].

• The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

  Kang R, Tang D, Schapiro N E, Loux T, Livesey K M, Billiar T R, Wang H, Van Houten B, Lotze M T and Zeh H J

  Oncogene. 2013 Jan 14; [Epub ahead of print].

• AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

  Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth B J, Viollet B, Mamer O A, Avizonis D, Deberardinis R J, Siegel P M and Jones R G

  Cell Metab; 2013 Jan 8. 17 (1):113-124.

• Acidity generated by the tumor microenvironment drives local invasion

  Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell H H, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg J M, Sloane B F, Johnson J, Gatenby R A and Gillies R J

  Cancer Res. 2013 Jan 3; [Epub ahead of print].

• Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null mice

  Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger W G, Schmelzle M, Usheva A, Tapper E B, Baffy G, Sukhatme V P, Wu Y and Robson S C

  Hepatology; 2013 Jan 1. 57 (1):205-16.

• The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells

  Hockenbery D, Tom M, Abikoff C and Margineantu D

  Cell Death Signaling in Cancer Biology and Treatment; 2013 Jan 1. 1 (2):35-51.

• Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

  Gershon T, Crowther A, Tikunov A, Garcia I, Annis R, Yuan H, Miller C, Macdonald J, Olson J and Deshmukh M

  Cancer Metab; 2013 Jan 1. 1 (2)

• LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

  Beckham T H, Lu P, Jones E E, Marrison T, Lewis C S, Cheng J C, Ramshesh V K, Beeson G, Beeson C C, Drake R R, Bielawska A, Bielawski J, Szulc Z M, Ogretmen B, Norris J S and Liu X

  J Pharmacol Exp Ther; 2013 Jan 1. 344 (1):167-178.

• MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

  Birsoy K, Wang T, Possemato R, Yilmaz O H, Koch C E, Chen W W, Hutchins A W, Gultekin Y, Peterson T R, Carette J E, Brummelkamp T R, Clish C B and Sabatini D M

  Nat Genet; 2012 Dec 16. 45 (1):104-8.

• Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer

  Silva A S, Kam Y, Khin Z P, Minton S E, Gillies R J and Gatenby R A

  Cancer Res; 2012 Dec 15. 72 (24):6362-70.

• Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3alpha/beta and Bax, leading to permeability transition pore opening and tumor cell death

  Chiara F, Gambalunga A, Sciacovelli M, Nicolli A, Ronconi L, Fregona D, Bernardi P, Rasola A and Trevisan A

  Cell Death Dis; 2012 Dec 14. 3 (e444)

• ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme

  Zadran S, Amighi A, Otiniano E, Wong K and Zadran H

  Tumour Biol; 2012 Dec 1. 33 (6):2411-21.

• The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

  Donohoe D R, Collins L B, Wali A, Bigler R, Sun W and Bultman S J

  Mol Cell; 2012 Nov 30. 48 (4):612-26.

• Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL

  Robinson G L, Dinsdale D, Macfarlane M and Cain K

  Oncogene; 2012 Nov 29. 31 (48):4996-5006.

• Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

  Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes R M, Klein M E, Takikita S, Nagashima K, Schmidt L S and Linehan W M

  J Natl Cancer Inst; 2012 Nov 21. 104 (22):1750-64.

• Comparative study of 3D morphology and functions on genetically engineered mouse melanoma cells

  Zhang Y, Feng Y, Justus C R, Jiang W, Li Z, Lu J Q, Brock R S, McPeek M K, Weidner D A, Yang L V and Hu X H

  Integr Biol (Camb); 2012 Nov 1. 4 (11):1428-1436.

• Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction

  Song N, Kim A J, Kim H J, Jee H J, Kim M, Yoo Y H and Yun J

  J Pineal Res; 2012 Nov 1. 53 (4):335-43.

• Glucose—a sweet way to die: Metabolic switching modulates tumor cell death

  MacFarlane M, Robinson G L and Cain K

  Cell Cycle; 2012 Nov 1. 11 (21):3919-25.

• Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: Implications for breast Cancer

  Sen S, Kawahara B and Chaudhuri G

  Free Radic Biol Med. 2012 Oct 23; [Epub ahead of print].

• Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma

  Caro P, Kishan A U, Norberg E, Stanley I A, Chapuy B, Ficarro S B, Polak K, Tondera D, Gounarides J, Yin H, Zhou F, Green M R, Chen L, Monti S, Marto J A, Shipp M A and Danial N N

  Cancer Cell; 2012 Oct 16. 22 (4):547-560.

• Importance of glycolysis and oxidative phosphorylation in advanced melanoma

  Ho J, de Moura M B, Lin Y, Vincent G, Thorne S, Duncan L M, Hui-Min L, Kirkwood J M, Becker D, Van Houten B and Moschos S J

  Mol Cancer; 2012 Oct 9. 11 (1):76.

• Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

  Sentelle R D, Senkal C E, Jiang W, Ponnusamy S, Gencer S, Panneer Selvam S, Ramshesh V K, Peterson Y K, Lemasters J J, Szulc Z M, Bielawski J and Ogretmen B

  Nat Chem Biol; 2012 Oct 1. 8 (10):831-8.

• An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression

  Jeong S H, Song I S, Kim H K, Lee S R, Song S, Suh H, Yoon Y G, Yoo Y H, Kim N, Rhee B D, Ko K S and Han J

  Mol Cells; 2012 Oct 1. 34 (4):357-365.

• Pyruvate Uptake Is Increased in Highly Invasive Ovarian Cancer Cells under Anoikis Conditions for Anaplerosis, Mitochondrial Function, and Migration

  Caneba C, Bellance N, Yang L, Pabst L and Nagrath D

  Am J Physiol Endocrinol Metab; 2012 Oct 1. 303 (8):E1036-52.

• Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

  Mantel C, Messina-Graham S, Moh A, Cooper S, Hangoc G, Fu X Y and Broxmeyer H E

  Blood; 2012 Sep 27. 120 (13):2589-99.

• Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

  Janiszewska M, Suva M L, Riggi N, Houtkooper R H, Auwerx J, Clement-Schatlo V, Radovanovic I, Rheinbay E, Provero P and Stamenkovic I

  Genes Dev; 2012 Sep 1. 26 (17):1926-44.

• Kinase Suppressor of Ras-2 (KSR2) Regulates Tumor Cell Transformation Via AMPK

  Fernandez M R, Henry M D and Lewis R E

  Mol Cell Biol; 2012 Sep 1. 32 (18):3718-31.

• STAT3 negatively regulates thyroid tumorigenesis

  Couto J P, Daly L, Almeida A, Knauf J A, Fagin J A, Sobrinho-Simoes M, Lima J, Maximo V, Soares P, Lyden D and Bromberg J F

  Proc Natl Acad Sci U S A; 2012 Aug 28. 109 (35):E2361-70.

• Mitochondrial respiration - an important therapeutic target in melanoma

  Barbi de Moura M, Vincent G, Fayewicz S L, Bateman N W, Hood B L, Sun M, Suhan J, Duensing S, Yin Y, Sander C, Kirkwood J M, Becker D, Conrads T P, Van Houten B and Moschos S J

  PLoS One; 2012 Aug 17. 7 (8):e40690.

• Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry

  Clerc P, Carey G B, Mehrabian Z, Wei M, Hwang H, Girnun G D, Chen H, Martin S S and Polster B M

  PLoS One; 2012 Aug 3. 7 (8):e42487.

• Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

  Bray K, Mathew R, Lau A, Kamphorst J J, Fan J, Chen J, Chen H Y, Ghavami A, Stein M, Dipaola R S, Zhang D, Rabinowitz J D and White E

  PLoS One; 2012 Aug 1. 7 (7):7/26/2012.

• Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

  Sukhatme V P and Chan B

  FEBS Lett; 2012 Jul 30. 586 (16):2389-95.

• Oncosecretomics coupled to bioenergetics identifies alpha-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes

  Bellance N, Pabst L, Allen G, Rossignol R and Nagrath D

  Biochim Biophys Acta; 2012 Jul 25. 1817 (11):2060-2071.

• PGC-1beta mediates adaptive chemoresistance associated with mitochondrial DNA mutations

  Yao Z, Jones A W, Fassone E, Sweeney M G, Lebiedzinska M, Suski J M, Wieckowski M R, Tajeddine N, Hargreaves I P, Yasukawa T, Tufo G, Brenner C, Kroemer G, Rahman S and Szabadkai G

  Oncogene. 2012 Jul 9; [Epub ahead of print].

• A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer

  Yang Y, Valera V, Sourbier C, Vocke C D, Wei M, Pike L, Huang Y, Merino M A, Bratslavsky G, Wu M, Ricketts C J and Linehan W M

  Cancer Genet; 2012 Jul 1. 205 (7-8):377-390.

• Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms

  Sassi N, Biasutto L, Mattarei A, Carraro M, Giorgio V, Citta A, Bernardi P, Garbisa S, Szabo I, Paradisi C and Zoratti M

  Biochim Biophys Acta; 2012 Jul 1. 1817 (7):1095-106.

• An NQO1 substrate with potent anti-tumor activity that selectively kills by PARP1-induced programmed necrosis

  Huang X, Dong Y, Bey E A, Kilgore J A, Bair J S, Li L S, Patel M, Parkinson E, Wang Y, Williams N S, Gao J, Hergenrother P J and Boothman D A

  Cancer Res; 2012 Jun 15. 72 (12):3038-47.

• Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

  Diers A R, Broniowska K A, Chang C F and Hogg N

  Biochem J; 2012 Jun 15. 444 (3):561-71.

• Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme

  Liu S, Bae Y, Leggas M, Daily A, Bhatnagar S, Miriyala S, St Clair D and Moscow J A

  J Pharmacol Exp Ther; 2012 Jun 1. 341 (3):775-83.

• Inhibiting Systemic Autophagy during Interleukin 2 (IL-2) Immunotherapy Promotes Long-term Tumor Regression

  Liang X, De Vera M E, Buchser W J, de Vivar Chavez A R, Loughran P, Stolz D B, Basse P, Wang T, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cancer Res; 2012 Jun 1. 72 (11):2791-801.

• Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target

  Gerlinger M, Santos C R, Spencer-Dene B, Martinez P, Endesfelder D, Burrell R A, Vetter M, Jiang M, Saunders R E, Kelly G, Rioux-Leclercq N, Stamp G, Patard J J, Larkin J, Howell M and Swanton C

  J Pathol; 2012 Jun 1. 227 (2):146-56.

• Disruption of fnip1 reveals a metabolic checkpoint controlling B lymphocyte development

  Park H, Staehling K, Tsang M, Appleby M W, Brunkow M E, Margineantu D, Hockenbery D M, Habib T, Liggitt H D, Carlson G and Iritani B M

  Immunity; 2012 May 25. 36 (5):769-781.

• Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

  Graves J A, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca M F, Elster J, Beer-Stolz D, Van Houten B, Vockley J and Prochownik E V

  PLoS One; 2012 May 21. 7 (5):e37699.

• Mitochondria targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death

  Cheng G, Zielonka J, Dranka B P, McAllister D, Mackinnon A C, Jr., Joseph J and Kalyanaraman B

  Cancer Res; 2012 May 15. 72 (10):2634-44.

• Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo

  Yaromina A, Meyer S, Fabian C, Zaleska K, Sattler U G, Kunz-Schughart L A, Mueller-Klieser W, Zips D and Baumann M

  Strahlenther Onkol; 2012 May 1. 188 (5):431-7.

• Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

  Chiu W H, Luo S J, Chen C L, Cheng J H, Hsieh C Y, Wang C Y, Huang W C, Su W C and Lin C F

  Biochem Pharmacol; 2012 May 1. 83 (9):1159-71.

• Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

  Perciavalle R M, Stewart D P, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland M M, Pelletier S, Schuetz J D, Youle R J, Green D R and Opferman J T

  Nat Cell Biol; 2012 Apr 29. 14 (6):575-583.

• Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

  Xun Z, Lee D Y, Lim J, Canaria C A, Barnebey A, Yanonne S M and McMurray C T

  Mech Ageing Dev; 2012 Apr 1. 133 (4):176-85.

• Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

  Quijano C, Cao L, Fergusson M M, Romero H, Liu J, Gutkind S, Rovira, II, Mohney R P, Karoly E D and Finkel T

  Cell Cycle; 2012 Apr 1. 11 (7):1383-1392.

• Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

  Garcia-Cao I, Song M S, Hobbs R M, Laurent G, Giorgi C, de Boer V C, Anastasiou D, Ito K, Sasaki A T, Rameh L, Carracedo A, Vander Heiden M G, Cantley L C, Pinton P, Haigis M C and Pandolfi P P

  Cell; 2012 Mar 30. 149 (1):49-62.

• The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

  Formentini L, Sanchez-Arago M, Sanchez-Cenizo L and Cuezva J M

  Mol Cell; 2012 Mar 30. 45 (6):731-742.

• AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells

  Martinez-Reyes I, Sanchez-Arago M and Cuezva J M

  Biochem J; 2012 Mar 21. 444 (2):249-59.

• Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts

  Fabian C, Koetz L, Favaro E, Indraccolo S, Mueller-Klieser W and Sattler U G

  FEBS J; 2012 Mar 1. 279 (5):882-91.

• Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

  Hu J, Hwang S S, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin A T, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang Y A, Shirihai O S, Chin L and Depinho R A

  Cell; 2012 Feb 17. 148 (4):651-663.

• Dysregulation of Ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

  Ren L, Hong S H, Chen Q R, Briggs J, Cassavaugh J, Srinivasan S, Lizardo M M, Mendoza A, Xia A Y, Avadhani N, Khan J and Khanna C

  Cancer Res; 2012 Feb 15. 72 (4):1001-12.

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

  Chen V, Staub R E, Fong S, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One; 2012 Feb 3. 7 (2):e30300.

• Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

  Yang J, Staples O, Thomas L W, Briston T, Robson M, Poon E, Simoes M L, El-Emir E, Buffa F M, Ahmed A, Annear N P, Shukla D, Pedley B, Maxwell P H, Harris A L and Ashcroft M

  J Clin Invest; 2012 Feb 1. 122 (2):600-11.

• Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

  Sandulache V C, Skinner H D, Ow T J, Zhang A, Xia X, Luchak J M, Wong L J, Pickering C R, Zhou G and Myers J N

  Cancer; 2012 Feb 1. 118 (3):711-21.

• Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1

  Ohkouchi S, Block G J, Katsha A M, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T and Prockop D J

  Mol Ther; 2012 Feb 1. 20 (2):417-23.

• Akt3 controls VEGF secretion and angiogenesis in ovarian cancer cells

  Liby T A, Spyropoulos P, Lindner H B, Eldridge J, Beeson C, Hsu T and Muise-Helmericks R C

  Int J Cancer; 2012 Feb 1. 130 (3):532-43.

• Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle

  Chen V, Staub R E, Baggett S, Chimmani R, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One; 2012 Jan 17. 7 (1):e30107.

• Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

  Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis L M and Weihua Z

  Cancer Res; 2012 Jan 1. 72 (1):304-14.

• Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model

  Ibrahim-Hashim A, Wojtkowiak J W, Ribeiro M d L C, Estrella V, Bailey K M, Cornnell H H, Gatenby R A and Gillies R J

  J Cancer Sci Ther S1; 2011 Nov 19.

• Targeting chaperone-mediated autophagy in cancer

  Thorburn A and Debnath J

  Sci Transl Med; 2011 Nov 16. 3 (109):109ps145.

• Chaperone-mediated autophagy is required for tumor growth

  Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L and Cuervo A M

  Sci Transl Med; 2011 Nov 16. 3 (109):109ra117.

• Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

  Wang X and Moraes C T

  Mol Oncol; 2011 Oct 1. 5 (5):399-409.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency

  Kim J H, Kim H Y, Lee Y K, Yoon Y S, Xu W G, Yoon J K, Choi S E, Ko Y G, Kim M J, Lee S J, Wang H J and Yoon G

  Autophagy; 2011 Oct 1. 7 (10):1187-1198.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

  Tong W H, Sourbier C, Kovtunovych G, Jeong S Y, Vira M, Ghosh M, Romero V V, Sougrat R, Vaulont S, Viollet B, Kim Y S, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan W M and Rouault T A

  Cancer Cell; 2011 Sep 13. 20 (3):315-327.

• Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

  Cvrljevic A N, Akhavan D, Wu M, Martinello P, Furnari F B, Johnston A J, Guo D, Pike L, Cavenee W K, Scott A M, Mischel P S, Hoogenraad N J and Johns T G

  J Cell Sci; 2011 Sep 1. 124 (Pt 17):2938-2950.

• Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

  Frezza C, Zheng L, Folger O, Rajagopalan K N, Mackenzie E D, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson I P, Pollard P J, Watson D G, Deberardinis R J, Shlomi T, Ruppin E and Gottlieb E

  Nature; 2011 Aug 17. 477 (7363):225-8.

• Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

  Hahm E R, Moura M B, Kelley E E, Van Houten B, Shiva S and Singh S V

  PLoS One; 2011 Aug 10. 6 (8):e23354.

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Chan D A, Sutphin P D, Nguyen P, Turcotte S, Lai E W, Banh A, Reynolds G E, Chi J T, Wu J, Solow-Cordero D E, Bonnet M, Flanagan J U, Bouley D M, Graves E E, Denny W A, Hay M P and Giaccia A J

  Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.

• Akt-dependent glucose metabolism promotes mcl-1 synthesis to maintain cell survival and resistance to bcl-2 inhibition

  Coloff J L, Macintyre A N, Nichols A G, Liu T, Gallo C A, Plas D R and Rathmell J C

  Cancer Res; 2011 Aug 1. 71 (15):5204-5213.

• Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

  Parkhitko A, Myachina F, Morrison T A, Hindi K M, Auricchio N, Karbowniczek M, Wu J J, Finkel T, Kwiatkowski D J, Yu J J and Henske E P

  Proc Natl Acad Sci U S A; 2011 Jul 26. 108 (30):12455-12460.

• E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells

  Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares L K, Lledo G, Tondeur S, Dubus P, Sardet C and Le Cam L

  J Exp Med; 2011 Jul 4. 208 (7):1403-1417.

• The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

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  Biomaterials; 2011 Jul 1. 32 (20):4565-4573.

• Dietary Fish Oil Promotes Colonic Apoptosis and Mitochondrial Proton Leak in Oxidatively Stressed Mice

  Fan Y Y, Ran Q, Toyokuni S, Okazaki Y, Callaway E S, Lupton J R and Chapkin R S

  Cancer Prev Res (Phila); 2011 Jul 1. 4 (18):1267-1274.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Mitochondrial Dysfunction Impairs Tumor Suppressor p53 Expression/Function

  Compton S, Kim C, Griner N B, Potluri P, Scheffler I E, Sen S, Jerry D J, Schneider S and Yadava N

  J Biol Chem; 2011 Jun 10. 286 (23):20297-20312.

• Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

  Zhang J, Guan Z, Murphy A N, Wiley S E, Perkins G A, Worby C A, Engel J L, Heacock P, Nguyen O K, Wang J H, Raetz C R, Dowhan W and Dixon J E

  Cell Metab; 2011 Jun 8. 13 (6):690-700.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• AMPK regulates metabolism and survival in response to ionizing radiation

  Zannella V E, Cojocari D, Hilgendorf S, Vellanki R N, Chung S, Wouters B G and Koritzinsky M

  Radiother Oncol; 2011 Jun 1. 99 (3):293-299.

• Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1{alpha} and Estrogen-Related Receptor {alpha} To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth

  Fisher K W, Das B, Kortum R L, Chaika O V and Lewis R E

  Mol Cell Biol; 2011 Jun 1. 31 (12):2453-2461.

• Bax Supports the Mitochondrial Network, Promoting Bioenergetics in Non-Apoptotic Cells

  Boohaker R J, Zhang G, Carlson A L, Nemec K N and Khaled A R

  Am J Physiol Cell Physiol; 2011 Jun 1. 300 (6):466-478.

• Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

  Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole R N, Pandey A and Semenza G L

  Cell; 2011 May 27. 145 (5):732-744.

• Pancreatic cancers require autophagy for tumor growth

  Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel J M, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai O S, Doglioni C, Bardeesy N and Kimmelman A C

  Genes Dev; 2011 Apr 1. 25 (7):717-729.

• Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

  Benitez A C, Dai Z, Mann H H, Reeves R S, Margineantu D H, Gooley T A, Groh V and Spies T

  Proc Natl Acad Sci U S A; 2011 Mar 8. 108 (10):4081-4086.

• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

  Yamasaki T, Tran T A, Oz O K, Raj G V, Schwarz R E, Deberardinis R J, Zhang X and Brugarolas J

  Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.

• Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

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  Genes Dev; 2011 Mar 1. 25 (5):460-470.

• Development of chromanes as novel inhibitors of the uncoupling proteins

  Rial E, Rodriguez-Sanchez L, Aller P, Guisado A, Mar Gonzalez-Barroso M, Gallardo-Vara E, Redondo-Horcajo M, Castellanos E, Fernandez de la Pradilla R and Viso A

  Chem Biol; 2011 Feb 25. 18 (2):264-274.

• The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

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  J Transl Med; 2011 Feb 10. 9 (19)

• On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate

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  Neoplasia; 2011 Jan 1. 13 (1):60-71.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

  Oliva C R, Nozell S E, Diers A, McClugage S G, 3rd, Sarkaria J N, Markert J M, Darley-Usmar V M, Bailey S M, Gillespie G Y, Landar A and Griguer C E

  J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.

• CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation

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  Cell Cycle; 2010 Dec 15. 9 (24):4941-4953.

• Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

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  Am J Pathol; 2010 Dec 1. 177 (6):3133-3144.

• Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

  Pike L S, Smift A L, Croteau N J, Ferrick D A and Wu M

  Biochim Biophys Acta. 2010 Nov 12; [Epub ahead of print].

• Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts

  Graves J A, Rothermund K, Wang T, Qian W, Van Houten B and Prochownik E V

  PLoS One; 2010 Oct 28. 5 (10):e13717.

• Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents

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  PLoS One; 2010 Oct 13. 5 (10):e13289.

• Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity

  Millard M, Pathania D, Shabaik Y, Taheri L, Deng J and Neamati N

  PLoS One; 2010 Oct 4. 5 (10):e13131.

• Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

  Xiao D, Powolny A A, Moura M B, Kelley E E, Bommareddy A, Kim S H, Hahm E R, Normolle D, Van Houten B and Singh S V

  J Biol Chem; 2010 Aug 20. 285 (34):26558-26569.

• Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype

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  J Biol Chem; 2010 Aug 13. 285 (33):25308-25313.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

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  Methods; 2010 Aug 1. 51 (4):452-457.

• Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

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  Proceedings of the National Academy of Sciences; 2010 Jun 8. 107 (23):10696-10701.

• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

  Weinberg F, Hamanaka R, Wheaton W W, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu G M, Budinger G R and Chandel N S

  Proc Natl Acad Sci U S A; 2010 May 11. 107 (19):8788-8793.

• Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

  Blouin M J, Zhao Y, Zakikhani M, Algire C, Piura E and Pollak M

  Cancer Lett; 2010 Mar 28. 289 (2):246-253.

• Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers

  Alakhova D Y, Rapoport N Y, Batrakova E V, Timoshin A A, Li S, Nicholls D, Alakhov V Y and Kabanov A V

  J Control Release; 2010 Feb 25. 142 (1):89-100.

• UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

  Yang Y, Valera V A, Padilla-Nash H M, Sourbier C, Vocke C D, Vira M A, Abu-Asab M S, Bratslavsky G, Tsokos M, Merino M J, Pinto P A, Srinivasan R, Ried T, Neckers L and Linehan W M

  Cancer Genet Cytogenet; 2010 Jan 1. 196 (1):45-55.

• Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

  Cairns R A, Bennewith K L, Graves E E, Giaccia A J, Chang D T and Denko N C

  Clin Cancer Res; 2009 Dec 1. 15 (23):7170-7174.

• Polo-like kinases mediate cell survival in mitochondrial dysfunction

  Matsumoto T, Wang P Y, Ma W, Sung H J, Matoba S and Hwang P M

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14542-14546.

• Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

  de Groof A J, te Lindert M M, van Dommelen M M, Wu M, Willemse M, Smift A L, Winer M, Oerlemans F, Pluk H, Fransen J A and Wieringa B

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• Methods in Cancer Metabolism: Real-Time Measurement of Mitochondrial Respiration and Glycolysis Rates of Cancer Cells in a Microplate

  Wu M

  Am. Assoc. Cancer Res. Education Book; 2009 Apr 1. :295-300.

• LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

  Xie H, Valera V A, Merino M J, Amato A M, Signoretti S, Linehan W M, Sukhatme V P and Seth P

  Mol Cancer Ther; 2009 Mar 1. 8 (3):626-635.

• Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

  Slomiany M G, Grass G D, Robertson A D, Yang X Y, Maria B L, Beeson C and Toole B P

  Cancer Res; 2009 Feb 15. 69 (4):1293-1301.

• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292 (1):C125-136.

Cardiovascular

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• Identification of the molecular basis of doxorubicin-induced cardiotoxicity

  Zhang S, Liu X, Bawa-Khalfe T, Lu L S, Lyu Y L, Liu L F and Yeh E T

  Nature medicine; 2013 Nov 1. 18 (11):1639-1642.

• Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury

  Masuzawa A, Black K M, Pacak C A, Ericsson M, Barnett R J, Drumm C, Seth P, Bloch D B, Levitsky S, Cowan D B and McCully J D

  Am J Physiol Heart Circ Physiol.; 2013 Apr 1. 304 (7):H966-982.

• Role of dynamin-related protein 1 (drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus

  Hong Z, Kutty S, Toth P T, Marsboom G, Hammel J M, Chamberlain C, Ryan J J, Zhang H J, Sharp W W, Morrow E, Trivedi K, Weir E K and Archer S L

  Circ Res; 2013 Mar 1. 112 (5):802-815.

• Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

  Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan N G, Forcales S, Puri P L, Leone T C, Marine J E, Calkins H, Kelly D P, Judge D P and Chen H S

  Nature; 2013 Feb 7. 494 (7435):105-110.

• Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis

  Koczor C A, Torres R A, Fields E, Qin Q, Park J, Ludaway T, Russ R and Lewis W

  Lab Invest; 2013 Feb 1. 93 (2):151-8.

• Cellular Bioenergetics is an Important Determinant of the Molecular Imaging Signal Derived from Luciferase and the Sodium-Iodide Symporter

  Chang C, Chan A, Lin X, Higuchi T, Terrovitis J, Afzal J M, Rittenbach A, Sun D, Vakrou S, Woldemichael K, O'Rourke B, Wahl R, Pomper M, Tsui B and Abraham M R

  Circ Res; 2013 Feb 1. 112 (3):441-50.

• Protein O-GlcNAcylation is a Novel Cytoprotective Signal in Cardiac Stem Cells

  Zafir A, Readnower R, Long B W, McCracken J, Aird A, Alvarez A, Cummins T D, Li Q, Hill B G, Bhatnagar A, Prabhu S D, Bolli R and Jones S P

  Stem Cells. 2013 Jan 17; [Epub ahead of print].

• Parkin Deficiency Exacerbates Cardiac Injury and Reduces Survival Following Myocardial Infarction

  Kubli D A, Zhang X, Lee Y, Hanna R A, Quinsay M N, Nguyen C K, Jimenez R, Petrosyan S, Murphy A N and Gustafsson A B

  J Biol Chem; 2013 Jan 11. 288 (2):915-26.

• Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells

  Diers A R, Broniowska K A and Hogg N

  Redox Biology; 2013 Jan 7. 1 (1):1-7.

• Myocardial accumulation of bupivacaine and ropivacaine is associated with reversible effects on mitochondria and reduced myocardial function

  Hiller N, Mirtschink P, Merkel C, Knels L, Oertel R, Christ T, Deussen A, Koch T and Stehr S N

  Anesth Analg; 2013 Jan 1. 116 (1):83-92.

• Standardized Bioenergetic Profiling of Adult Mouse Cardiomyocytes

  Readnower R D, Brainard R E, Hill B G and Jones S P

  Physiol Genomics; 2012 Dec 18. 44 (24):1208-13.

• GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

  Tocchetti C G, Caceres V, Stanley B A, Xie C, Shi S, Watson W H, O'Rourke B, Spadari-Bratfisch R C, Cortassa S, Akar F G, Paolocci N and Aon M A

  Diabetes; 2012 Dec 1. 61 (12):3094-3105.

• Enhanced phosphoinositide 3-kinase(p110alpha) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

  Ritchie R H, Love J E, Huynh K, Bernardo B C, Henstridge D C, Kiriazis H, Tham Y K, Sapra G, Qin C, Cemerlang N, Boey E J, Jandeleit-Dahm K, Du X J and McMullen J R

  Diabetologia; 2012 Dec 1. 55 (12):3369-81.

• Characterization of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

  Rana P, Anson B, Engle S and Will Y

  Toxicol Sci; 2012 Nov 1. 130 (1):117-31.

• OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

  Chen L, Liu T, Tran A, Lu X, Tomilov A A, Davies V, Cortopassi G, Chiamvimonvat N, Bers D M, Votruba M and Knowlton A A

  Journal of the American Heart Association; 2012 Oct 25. 1 (5)

• The Methyl Xanthine Caffeine Inhibits DNA Damage Signaling and Reactive Species and Reduces Atherosclerosis in ApoE-/- Mice

  Mercer J R, Gray K, Figg N, Kumar S and Bennett M R

  Arterioscler Thromb Vasc Biol; 2012 Oct 1. 32 (10):2461-7.

• Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase

  Mo L, Wang Y, Geary L, Corey C, Alef M J, Beer-Stolz D, Zuckerbraun B S and Shiva S

  Free Radic Biol Med; 2012 Aug 4. 53 (7):1440-1450.

• Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

  Liu Y, Nguyen P, Baris T Z and Poirier M C

  Cardiovasc Toxicol; 2012 Jun 1. 12 (2):123-34.

• Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension

  Marsboom G, Toth P T, Ryan J J, Hong Z, Wu X, Fang Y H, Thenappan T, Piao L, Zhang H J, Pogoriler J, Chen Y, Morrow E, Weir E K, Rehman J and Archer S L

  Circ Res; 2012 May 25. 110 (11):1484-1497.

• Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1? and mitochondrial respiration

  Reiter C E N and Alayash A I

  FEBS Open Bio; 2012 May 24. 2 (2012):113-118.

• A Cell-Based Phenotypic Assay to Identify Cardioprotective Agents

  Guo S, Olm-Shipman A, Walters A, Urciuoli W R, Devito S, Nadtochiy S M, Wojtovich A P and Brookes P S

  Circ Res; 2012 Mar 30. 110 (7):948-57.

• GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling

  Willaert A, Khatri S, Callewaert B L, Coucke P J, Crosby S D, Lee J G, Davis E C, Shiva S, Tsang M, De Paepe A and Urban Z

  Hum Mol Genet; 2012 Mar 15. 21 (6):1248-59.

• Lung 18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

  Marsboom G, Wietholt C, Haney C R, Toth P T, Ryan J J, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen C T and Archer S L

  Am J Respir Crit Care Med; 2012 Mar 15. 185 (6):670-679.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.

• Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle

  Fang Y H, Piao L, Hong Z, Toth P T, Marsboom G, Bache-Wiig P, Rehman J and Archer S L

  J Mol Med (Berl); 2012 Jan 1. 90 (1):31-43.

• Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

  Szanto M, Rutkai I, Hegedus C, Czikora A, Rozsahegyi M, Kiss B, Virag L, Gergely P, Toth A and Bai P

  Cardiovasc Res; 2011 Dec 1. 92 (3):430-438.

• Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

  Mullen P J, Zahno A, Lindinger P, Maseneni S, Felser A, Krahenbuhl S and Brecht K

  Biochim Biophys Acta; 2011 Dec 1. 1813 (12):2079-87.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells

  Diers A R, Broniowska K A, Darley-Usmar V M and Hogg N

  Am J Physiol Heart Circ Physiol; 2011 Sep 1. 301 (3):H803-812.

• Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

  Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A and Szabo C

  Proc Natl Acad Sci U S A; 2011 Aug 16. 108 (33):13829-13834.

• Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

  Liesa M, Luptak I, Qin F, Hyde B B, Sahin E, Siwik D A, Zhu Z, Pimentel D R, Xu X J, Ruderman N B, Huffman K D, Doctrow S R, Richey L, Colucci W S and Shirihai O S

  Circulation; 2011 Aug 16. 124 (7):806-813.

• Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

  Souza S C, Chau M D, Yang Q, Gauthier M S, Clairmont K B, Wu Z, Gromada J and Dole W P

  Biochem Biophys Res Commun; 2011 Jul 8. 410 (3):398-403.

• Mitochondria determine the differentiation potential of cardiac mesoangioblasts

  San Martin N, Cervera A M, Cordova C, Covarello D, McCreath K J and Galvez B G

  Stem Cells; 2011 Jul 1. 29 (7):1064-1074.

• Bioenergetic function in cardiovascular cells: The importance of the reserve capacity and its biological regulation

  Sansbury B E, Jones S P, Riggs D W, Darley-Usmar V M and Hill B G

  Chem Biol Interact; 2011 May 30. 191 (1-3):288-295.

• Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism

  Sansbury B E, Riggs D W, Brainard R E, Salabei J K, Jones S P and Hill B G

  Biochem J; 2011 Apr 15. 435 (2):519-528.

• Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

  Devarajan A, Bourquard N, Hama S, Navab M, Grijalva V R, Morvardi S, Clarke C F, Vergnes L, Reue K, Teiber J F and Reddy S T

  Antioxid Redox Signal; 2011 Feb 1. 14 (3):341-351.

• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy

  Moslehi J, Minamishima Y A, Shi J, Neuberg D, Charytan D M, Padera R F, Signoretti S, Liao R and Kaelin W G, Jr.

  Circulation; 2010 Sep 7. 122 (10):1004-1016.

• Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

  Perez J, Hill B G, Benavides G A, Dranka B P and Darley-Usmar V M

  Biochem J; 2010 Jun 1. 428 (2):255-267.

• Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

  Dranka B P, Hill B G and Darley-Usmar V M

  Free Radic Biol Med; 2010 Apr 1. 48 (7):905-914.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation

  Hill B G, Higdon A N, Dranka B P and Darley-Usmar V M

  Biochim Biophys Acta; 2010 Feb 1. 1797 (2):285-295.

• Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

  Hill B G, Dranka B P, Zou L, Chatham J C and Darley-Usmar V M

  Biochem J; 2009 Nov 15. 424 (1):99-107.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10 (4):273-284.

• O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration

  Sridharan V, Guichard J, Li C Y, Muise-Helmericks R, Beeson C C and Wright G L

  Am J Physiol Cell Physiol; 2008 Jul 1. 295 (1):C29-37.

• Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

  Simonides W S, Mulcahey M A, Redout E M, Muller A, Zuidwijk M J, Visser T J, Wassen F W, Crescenzi A, da-Silva W S, Harney J, Engel F B, Obregon M J, Larsen P R, Bianco A C and Huang S A

  J Clin Invest; 2008 Mar 1. 118 (3):975-983.

• ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart

  Alaynick W A, Kondo R P, Xie W, He W, Dufour C R, Downes M, Jonker J W, Giles W, Naviaux R K, Giguere V and Evans R M

  Cell Metab; 2007 Jul 1. 6 (1):13-24.

• The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

  Sridharan V, Guichard J, Bailey R M, Kasiganesan H, Beeson C and Wright G L

  Am J Physiol Cell Physiol; 2007 Feb 1. 292 (2):C719-728.

Cell Physiology

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• WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

  Esen E, Chen J, Karner C M, Okunade A L, Patterson B W and Long F

  Cell metabolism; 2013 May 7. 14 (5):745-55.

• Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

  Lopez-Erauskin J, Galino J, Ruiz M, Cuezva J M, Fabregat I, Cacabelos D, Boada J, Martinez J, Ferrer I, Pamplona R, Villarroya F, Portero-Otin M, Fourcade S and Pujol A

  Human molecular genetics; 2013 May 3.

• Lacritin rescues stressed epithelia via rapid FOXO3 associated autophagy that restores metabolism

  Wang N, Zimmerman K, Raab R W, McKown R L, Hutnik C M, Talla V, Tyler M F, Lee J K and Laurie G W

  J Biol Chem. 2013 May 2; [Epub ahead of print].

• A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

  McQuaker S J, Quinlan C L, Caldwell S T, Brand M D and Hartley R C

  Chembiochem. 2013 May 2; [Epub ahead of print].

• MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein

  Han K S and Ayer D E

  Biochem J. 2013 May 1; [Epub ahead of print].

• The role of p38 in mitochondrial respiration in male and female mice

  Ju X, Wen Y, Metzger D and Jung M

  Neurosci Lett. 2013 Apr 17; [Epub ahead of print].

• The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

  Anedda A, Lopez-Bernardo E, Acosta-Iborra B, Saadeh Suleiman M, Landazuri M O and Cadenas S

  Free Radic Biol Med. 2013 Apr 16; [Epub ahead of print].

• Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress

  Sun Q, Gao W, Loughran P, Shapiro R, Fan J, Billiar T R and Scott M J

  J Biol Chem. 2013 Apr 15; [Epub ahead of print].

• Global analysis of SUMO chain function reveals multiple roles in chromatin regulation

  Srikumar T, Lewicki M C, Costanzo M, Tkach J M, van Bakel H, Tsui K, Johnson E S, Brown G W, Andrews B J, Boone C, Giaever G, Nislow C and Raught B

  J Cell Biol; 2013 Apr 1. 201 (1):145-163.

• Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

  Modis K, Asimakopoulou A, Coletta C, Papapetropoulos A and Szabo C

  Biochem Biophys Res Commun. 2013 Mar 26; [Epub ahead of print].

• Characterization of transgenic Gfrp knock-in mice: Implications for tetrahydrobiopterin in modulation of normal tissue radiation responses

  Pathak R, Pawar S, Fu Q, Gupta P K, Berbee M, Garg S, Sridharn V, Wang W, Prabath B, Krager K, Boerma M, Ghosh S, Cheema A, Hendrickson H, Aykin-Burns N and Hauer-Jensen M

  Antioxid Redox Signal. 2013 Mar 23; [Epub ahead of print].

• Glutaredoxin-2 Is Required to Control Proton Leak through Uncoupling Protein-3

  Mailloux R J, Xuan J Y, Beauchamp B, Jui L, Lou M and Harper M E

  J Biol Chem; 2013 Mar 22. 288 (12):8365-8379.

• Mitochondrial matrix P53 sensitizes cells to oxidative stress

  Koczor C A, Torres R A, Fields E J, Boyd A and Lewis W

  Mitochondrion; 2013 Mar 14. 13 (14):277-281.

• alpha-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKalpha in vitro

  Wang L and Brautigan D L

  Nat Commun; 2013 Mar 7. 4 (1559)

• Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1

  Rafikov R, Rafikova O, Aggarwal S, Gross C, Sun X, Desai J, Fulton D and Black S M

  J Biol Chem; 2013 Mar 1. 288 (9):6212-6226.

• Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

  Modis K, Coletta C, Erdelyi K, Papapetropoulos A and Szabo C

  FASEB J; 2013 Feb 1. 27 (2):601-611.

• Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

  Rensvold Jarred W, Ong S-E, Jeevananthan A, Carr Steven A, Mootha Vamsi K and Pagliarini David J

  Cell Reports; 2013 Jan 31. 3 (1):237-45.

• Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+-activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3

  Amigo I, Traba J, Gonzalez-Barroso M M, Rueda C B, Fernandez M, Rial E, Sanchez A, Satrustegui J and Del Arco A

  J Biol Chem. 2013 Jan 23; [Epub ahead of print].

• Integrating Mitochondrial Energetics, Redox and ROS Metabolic Networks: A Two-Compartment Model

  Kembro Jackelyn M, Aon Miguel A, Winslow Raimond L, O’Rourke B and Cortassa S

  Biophysical Journal. 2013 Jan 22; [Epub ahead of print].

• Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells

  Diers A R, Broniowska K A and Hogg N

  Redox Biology; 2013 Jan 7. 1 (1):1-7.

• Mitochondrially targeted compounds and their impact on cellular bioenergetics

  Reily C, Mitchell T, Chacko B K, Benavides G A, Murphy M P and Darley-Usmar V M

  Redox Biology; 2013 Jan 1. 1 (1):86-93.

• Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

  Lin H Y, Lai R H, Lin S T, Lin R C, Wang M J, Lin C C, Lee H C, Wang F F and Chen J Y

  Cell Death Differ; 2013 Jan 1. 20 (1):139-53.

• SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC1alpha

  Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh E T and Cheng J

  J Biol Chem; 2012 Dec 28. 287 (53):44464-70.

• Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions

  Zhang C, Huang V H, Simon M, Sharma L K, Fan W, Haas R, Wallace D C, Bai Y and Huang T

  FASEB J; 2012 Dec 1. 26 (12):4914-4924.

• Mitochondrial hyperfusion induced by loss of fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

  Qian W, Choi S, Gibson G A, Watkins S C, Bakkenist C J and Houten B V

  J Cell Sci; 2012 Dec 1. 125 (Pt 23):5745-57.

• MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism

  Mallilankaraman K, Cardenas C, Doonan P J, Chandramoorthy H C, Irrinki K M, Golenar T, Csordas G, Madireddi P, Yang J, Muller M, Miller R, Kolesar J E, Molgo J, Kaufman B, Hajnoczky G, Foskett J K and Madesh M

  Nat Cell Biol; 2012 Dec 1. 14 (12):1336-1343.

• Integration of cellular bioenergetics with mitochondrial quality control and autophagy

  Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M

  Biol Chem; 2012 Nov 1. 393 (12):1485-1512.

• MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake that Regulates Cell Survival

  Mallilankaraman K, Doonan P, Cardenas C, Chandramoorthy H C, Muller M, Miller R, Hoffman N E, Gandhirajan R K, Molgo J, Birnbaum M J, Rothberg B S, Mak D O, Foskett J K and Madesh M

  Cell; 2012 Oct 26. 151 (3):630-644.

• Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

  Raichur S, Hooi Teh S, Ohwaki K, Gaur V, Chau Long Y, Hargreaves M, McGee S L and Kusunoki J

  J Mol Endocrinol; 2012 Oct 12. 49 (3):203-211.

• Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species

  Hurd T R, Collins Y, Abakumova I, Chouchani E T, Baranowski B, Fearnley I M, Prime T A, Murphy M P and James A M

  J Biol Chem; 2012 Oct 12. 287 (42):35153-35160.

• Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

  Sentelle R D, Senkal C E, Jiang W, Ponnusamy S, Gencer S, Panneer Selvam S, Ramshesh V K, Peterson Y K, Lemasters J J, Szulc Z M, Bielawski J and Ogretmen B

  Nat Chem Biol; 2012 Oct 1. 8 (10):831-8.

• Role of TRIB3 in Regulation of Insulin Sensitivity and Nutrient Metabolism during Short-term Fasting and Nutrient Excess

  Liu J, Zhang W, Chuang G C, Hill H S, Tian L, Fu Y, Moellering D R and Garvey W T

  Am J Physiol Endocrinol Metab; 2012 Oct 1. 303 (7):E908-16.

• Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

  Mantel C, Messina-Graham S, Moh A, Cooper S, Hangoc G, Fu X Y and Broxmeyer H E

  Blood; 2012 Sep 27. 120 (13):2589-99.

• GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence

  Byun H O, Jung H J, Seo Y H, Lee Y K, Hwang S C, Seong Hwang E and Yoon G

  Exp Cell Res; 2012 Sep 10. 318 (15):1808-19.

• Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

  Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper R H, Auwerx J, Franken P and Tafti M

  J Neurosci; 2012 Sep 5. 32 (36):12506-12517.

• Bioenergetic Effects of Mitochondrial Targeted Coenzyme Q Analogs in Endothelial Cells

  Fink B D, Herlein J A, Yorek M A, Fenner A M, Kerns R J and Sivitz W I

  Journal of Pharmacology and Experimental Therapeutics; 2012 Sep 1. 342 (3):709-19.

• Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

  Siddiqui A, Chinta S J, Mallajosyula J K, Rajagopolan S, Hanson I, Rane A and Andersen J K

  Free Radical Biology and Medicine; 2012 Aug 15. 53 (4):993-1003.

• CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

  Kim SJ, Kwon MC, Ryu MJ, Chung HK, Tadi S, Kim YK, Man Kim J, Lee SH, Park JH, Kweon GR, Ryu SW, Jo YS, Lee CH, Hatakeyama H, Goto Y, Yim YH, Chung J, Kong YY, Shong M.

  Cell Metab; 2012 Aug 8. 16 (2):274-83.

• Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase

  Mo L, Wang Y, Geary L, Corey C, Alef M J, Beer-Stolz D, Zuckerbraun B S and Shiva S

  Free Radic Biol Med; 2012 Aug 4. 53 (7):1440-1450.

• Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

  Furda A M, Marrangoni A M, Lokshin A and Van Houten B

  DNA Repair (Amst); 2012 Aug 1. 11 (8):684-92.

• Expression Profiling of Attenuated Mitochondrial Function Identifies Retrograde Signals in Drosophila

  Freije W A, Mandal S and Banerjee U

  G3: Genes|Genomes|Genetics; 2012 Aug 1. 2 (8):843-851.

• Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor YY1 in skeletal muscle

  Blättler S M, Verdeguer F, Liesa M, Cunningham J T, Vogel R O, Chim H, Liu H, Romanino K, Shirihai O S, Vazquez F, Rüegg M A, Shi Y and Puigserver P

  Mol Cell Biol; 2012 Aug 1. 32 (16):3333-46.

• Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

  Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon C E, Zhang H, Neckers L and Pommier Y

  PLoS One; 2012 Jul 4. 7 (7):e41094.

• Acyl-CoA thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

  Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck C K, Genoud C, Cron P, Keusch J J, Dummler B, Esposti M D and Hemmings B A

  Mol Cell Biol; 2012 Jul 1. 32 (14):2685-97.

• Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms

  Sassi N, Biasutto L, Mattarei A, Carraro M, Giorgio V, Citta A, Bernardi P, Garbisa S, Szabo I, Paradisi C and Zoratti M

  Biochim Biophys Acta; 2012 Jul 1. 1817 (7):1095-106.

• Adjustments of Mitochondrial Energy Transduction in Response to Physiological and Environmental Challenge

  Jastroch M., T. Ruf (Eds. C. Bieber, W. Arnold and E. Millesi )

  Living in a Seasonal World; 2012 Jul 1. Springer Berlin Heidelberg (2012, Part 3):387-398.

• Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

  Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon V P, Bixby J L, Gereben B and Bianco A C

  The Journal of Neuroscience; 2012 Jun 20. 32 (25):8491-8500.

• An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

  Pascucci B, Lemma T, Iorio E, Giovannini S, Vaz B, Iavarone I, Calcagnile A, Narciso L, Degan P, Podo F, Roginskya V, Janjic B M, Van Houten B, Stefanini M, Dogliotti E and D'Errico M

  Aging Cell; 2012 Jun 1. 11 (3):520-29.

• Cellular Responses to the Metal-Binding Properties of Metformin

  Logie L, Harthill J, Patel K, Bacon S, Hamilton D L, Macrae K, McDougall G, Wang H H, Xue L, Jiang H, Sakamoto K, Prescott A R and Rena G

  Diabetes; 2012 Jun 1. 61 (6):1423-33.

• p53 and Mitochondrial DNA: Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals

  Koczor C A, White R C, Zhao P, Zhu L, Fields E and Lewis W

  Am J Pathol; 2012 Jun 1. 180 (6):2276-2283.

• Peroxisome Proliferator-Activated Receptor gamma Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

  Hu S, Yao J, Howe A A, Menke B M, Sivitz W I, Spector A A and Norris A W

  Mol Endocrinol; 2012 Jun 1. 26 (6):977-988.

• RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

  Croteau D L, Rossi M L, Canugovi C, Tian J, Sykora P, Ramamoorthy M, Wang Z, Singh D K, Akbari M, Kasiviswanathan R, Copeland W C and Bohr V A

  Aging Cell; 2012 Jun 1. 11 (3):456-66.

• Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

  Aon M A, Stanley B A, Sivakumaran V, Kembro J M, O'Rourke B, Paolocci N and Cortassa S

  J Gen Physiol; 2012 Jun 1. 139 (6):479-91.

• Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

  Fernandez-Marcos P J, Jeninga E H, Canto C, Harach T, de Boer V C, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten S M, Schoonjans K and Auwerx J

  Sci Rep; 2012 May 28. 2 (425)

• Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1? and mitochondrial respiration

  Reiter C E N and Alayash A I

  FEBS Open Bio; 2012 May 24. 2 (2012):113-118.

• Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

  Graves J A, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca M F, Elster J, Beer-Stolz D, Van Houten B, Vockley J and Prochownik E V

  PLoS One; 2012 May 21. 7 (5):e37699.

• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

  Hawley S A, Fullerton M D, Ross F A, Schertzer J D, Chevtzoff C, Walker K J, Peggie M W, Zibrova D, Green K A, Mustard K J, Kemp B E, Sakamoto K, Steinberg G R and Hardie D G

  Science; 2012 May 18. 336 (6083):918-22.

• Additive effects of mitochondria-targeted Cytochrome P4502E1 and alcohol toxicity on cytochrome c oxidase function and the stability of respirosome complexes

  Bansal S, Srinivasan S, Anandasadagopan S, Roy Chowdhury A, Selvaraj V, Kalyanaraman B, Joseph J and Avadhani N G

  J Biol Chem; 2012 May 4. 287 (19):15284-97.

• Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1

  Scott I, Webster B R, Li J H and Sack M N

  Biochem J; 2012 May 1. 443 (3):655-61.

• C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome

  Rorbach J, Gammage P A and Minczuk M

  Nucleic Acids Res; 2012 May 1. 40 (9):4097-109.

• Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression

  Li J, Liu X, Wang H, Zhang W, Chan D C and Shi Y

  Proc Natl Acad Sci U S A; 2012 May 1. 109 (18):6975-80.

• Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function

  Johnson A R, Lao S, Wang T, Galanko J A and Zeisel S H

  PLoS ONE; 2012 Apr 27. 7 (4):e36047.

• Chronic expression of RCAN1-1L induces mitochondrial autophagy and a metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells

  Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo A M and Davies K J

  J Biol Chem; 2012 Apr 20. 287 (17):14088-98.

• Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

  Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P C, Minor R K, Wilson Iii D M, Cooper M, Spencer R, de Cabo R, Croteau D L and Bohr V A

  J Exp Med; 2012 Apr 9. 209 (4):855-869.

• Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

  Clerc P and Polster B M

  PLoS One; 2012 Apr 4. 7 (3):e34465.

• Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

  Xun Z, Lee D Y, Lim J, Canaria C A, Barnebey A, Yanonne S M and McMurray C T

  Mech Ageing Dev; 2012 Apr 1. 133 (4):176-85.

• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

  Higdon A N, Benavides G A, Chacko B K, Ouyang X, Johnson M S, Landar A, Zhang J and Darley-Usmar V M

  Am J Physiol Heart Circ Physiol; 2012 Apr 1. 302 (7):H1394-409.

• A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

  Kitami T, Logan D J, Negri J, Hasaka T, Tolliday N J, Carpenter A E, Spiegelman B M and Mootha V K

  PLoS One; 2012 Mar 29. 7 (3):e33755.

• Correcting human mitochondrial mutations with targeted RNA import

  Wang G, Shimada E, Zhang J, Hong J S, Smith G M, Teitell M A and Koehler C M

  Proc Natl Acad Sci U S A; 2012 Mar 27. 109 (13):4840-4845.

• FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

  Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K and Nakao M

  Nat Commun; 2012 Mar 27. 3 (758)

• Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

  Modis K, Gero D, Erdelyi K, Szoleczky P, Dewitt D and Szabo C

  Biochem Pharmacol; 2012 Mar 1. 83 (5):633-643.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

  Seifert E L, Caron A Z, Morin K, Coulombe J, Hong He X, Jardine K, Dewar-Darch D, Boekelheide K, Harper M E and McBurney M W

  FASEB J; 2012 Feb 1. 26 (2):555-66.

• Role of mitofusin 2 in the renal stress response

  Gall J M, Wang Z, Liesa M, Molina A, Havasi A, Schwartz J H, Shirihai O, Borkan S C and Bonegio R G

  PLoS One; 2012 Jan 26. 7 (1):e31074.

• Integrin-Dependent Akt1 Activation Regulates PGC-1 Expression and Fatty Acid Oxidation

  Beeson C C, Beeson G C, Buff H, Eldridge J, Zhang A, Seth A, Demcheva M, Vournakis J N and Muise-Helmericks R C

  J Vasc Res; 2012 Jan 13. 49 (2):89-100.

• Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

  Yin F, Sancheti H and Cadenas E

  Biochim Biophys Acta; 2011 Dec 16. 1817 (3):401-409.

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2

  Gan Z, Burkart-Hartman E M, Han D H, Finck B, Leone T C, Smith E Y, Ayala J E, Holloszy J and Kelly D P

  Genes Dev; 2011 Dec 15. 25 (24):2619-30.

• Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

  Wang H, Sreenevasan U, Hu H, Saladino A, Polster B M, Lund L M, Gong D W, Stanley W C and Sztalryd C

  J Lipid Res; 2011 Dec 1. 52 (12):2159-2168.

• Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

  Szanto M, Rutkai I, Hegedus C, Czikora A, Rozsahegyi M, Kiss B, Virag L, Gergely P, Toth A and Bai P

  Cardiovasc Res; 2011 Dec 1. 92 (3):430-438.

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

  Zhang J, Khvorostov I, Hong J S, Oktay Y, Vergnes L, Nuebel E, Wahjudi P N, Setoguchi K, Wang G, Do A, Jung H J, McCaffery J M, Kurland I J, Reue K, Lee W N, Koehler C M and Teitell M A

  EMBO J; 2011 Nov 15. 30 (24):4860-4873.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B G, Zhang J, Landar A and Darley-Usmar V M

  Free Radic Biol Med; 2011 Nov 1. 51 (9):1621-1635.

• Molecular imaging of intracellular drug-membrane aggregate formation

  Baik J and Rosania G R

  Mol Pharm; 2011 Oct 3. 8 (5):1742-1749.

• The PGC-1{alpha}-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

  Philp A, Belew M Y, Evans A, Pham D, Sivia I, Chen A, Schenk S and Baar K

  Am J Physiol Regul Integr Comp Physiol; 2011 Oct 1. 301 (4):R864-872.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• Apoptosis induced by persistent single-strand breaks in the mitochondrial genome: Critical role of EXOG (5' EXO/Endonuclease) in their repair

  Tann A W, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S and Szczesny B

  J Biol Chem; 2011 Sep 16. 286 (37):31975-31983.

• Uncoupling proteins and the control of mitochondrial reactive oxygen species production

  Mailloux R J and Harper M E

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

  Rorbach J, Nicholls T J and Minczuk M

  Nucleic Acids Res; 2011 Sep 1. 39 (17):7750-7763.

• The Rate of Oxygen Utilization by Cells

  Wagner B A, Venkataraman S and Buettner G R

  Free Radical Biology and Medicine; 2011 Aug 1. 51 (3):700-712.

• Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

  Mailloux R J, Dumouchel T, Aguer C, deKemp R, Beanlands R and Harper M E

  Biochem J; 2011 Jul 15. 437 (2):301-311.

• Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

  Baughman J M, Perocchi F, Girgis H S, Plovanich M, Belcher-Timme C A, Sancak Y, Bao X R, Strittmatter L, Goldberger O, Bogorad R L, Koteliansky V and Mootha V K

  Nature; 2011 Jun 19. 476 (7360):341-345.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

  Bernier M, Paul R K, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He H J, Armour S M, Hubbard B P, Bohr V A, Wang L, Zong Y, Sinclair D A and de Cabo R

  J Biol Chem; 2011 Jun 3. 286 (22):19270-19279.

• Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

  Chambers J W and Lograsso P V

  J Biol Chem; 2011 May 6. 286 (18):16052-16062.

• Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

  Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann C W, Schoonjans K, Pozzan T, Spat A and Wollheim C B

  Cell Metab; 2011 May 4. 13 (5):601-611.

• TEFM (c17orf42) is necessary for transcription of human mtDNA

  Minczuk M, He J, Duch A M, Ettema T J, Chlebowski A, Dzionek K, Nijtmans L G, Huynen M A and Holt I J

  Nucleic Acids Res; 2011 May 1. 39 (10):4284-4299.

• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

  Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper R H, Schoonjans K, Schreiber V, Sauve A A, Menissier-de Murcia J and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):461-468.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Exercise and PGC-1alpha-independent synchronization of type I muscle metabolism and vasculature by ERRgamma

  Narkar V A, Fan W, Downes M, Yu R T, Jonker J W, Alaynick W A, Banayo E, Karunasiri M S, Lorca S and Evans R M

  Cell Metab; 2011 Mar 2. 13 (3):283-293.

• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

• ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

  Darshi M, Mendiola V L, Mackey M R, Murphy A N, Koller A, Perkins G A, Ellisman M H and Taylor S S

  J Biol Chem; 2011 Jan 28. 286 (4):2918-2932.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  Gurumurthy S, Xie S Z, Alagesan B, Kim J, Yusuf R Z, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park P J, Shirihai O S, Scadden D T and Bardeesy N

  Nature; 2010 Dec 2. 468 (7324):659-663.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

  Akhmedov D, Braun M, Mataki C, Park K S, Pozzan T, Schoonjans K, Rorsman P, Wollheim C B and Wiederkehr A

  FASEB J; 2010 Nov 1. 24 (11):4613-4626.

• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

  Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro J B, Adelmant G O, Marto J A, Rhee K, Tisdale S, Danial N, Benarafa C, Orduna A and Anderson P

  Biochem Biophys Res Commun; 2010 Oct 22. 401 (3):440-446.

• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

  Nasrin N, Wu X, Fortier E, Feng Y, Bare O C, Chen S, Ren X, Wu Z, Streeper R S and Bordone L

  J Biol Chem; 2010 Oct 15. 285 (42):31995-32002.

• MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

  Perocchi F, Gohil V M, Girgis H S, Bao X R, McCombs J E, Palmer A E and Mootha V K

  Nature; 2010 Sep 16. 467 (7313):291-296.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

  Qian W and Van Houten B

  Methods; 2010 Aug 1. 51 (4):452-457.

• Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

  Philp A, Perez-Schindler J, Green C, Hamilton D L and Baar K

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C240-250.

• Bioenergetic characterization of mouse podocytes

  Abe Y, Sakairi T, Kajiyama H, Shrivastav S, Beeson C and Kopp J B

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C464-476.

• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria

  Cardenas C, Miller R A, Smith I, Bui T, Molgo J, Muller M, Vais H, Cheung K H, Yang J, Parker I, Thompson C B, Birnbaum M J, Hallows K R and Foskett J K

  Cell; 2010 Jul 23. 142 (2):270-283.

• Wnt signaling regulates mitochondrial physiology and insulin sensitivity

  Yoon J C, Ng A, Kim B H, Bianco A, Xavier R J and Elledge S J

  Genes Dev; 2010 Jul 15. 24 (14):1507-1518.

• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

  Chau M D, Gao J, Yang Q, Wu Z and Gromada J

  Proc Natl Acad Sci U S A; 2010 Jul 13. 107 (28):12553-12558.

• Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

  Chinopoulos C, Gerencser A A, Mandi M, Mathe K, Torocsik B, Doczi J, Turiak L, Kiss G, Konrad C, Vajda S, Vereczki V, Oh R J and Adam-Vizi V

  FASEB J; 2010 Jul 1. 24 (7):2405-2416.

• Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

  Hawley S A, Ross F A, Chevtzoff C, Green K A, Evans A, Fogarty S, Towler M C, Brown L J, Ogunbayo O A, Evans A M and Hardie D G

  Cell Metab; 2010 Jun 9. 11 (6):554-565.

• Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

  Bao J, Lu Z, Joseph J J, Carabenciov D, Dimond C C, Pang L, Samsel L, McCoy J P, Jr., Leclerc J, Nguyen P, Gius D and Sack M N

  J Cell Biochem; 2010 May 1. 110 (1):238-247.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11 (3):213-219.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10 (4):273-284.

• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

  Wu N, Yin L, Hanniman E A, Joshi S and Lazar M A

  Genes Dev; 2009 Sep 15. 23 (18):2201-2209.

• Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

  Amo T, Yadava N, Oh R, Nicholls D G and Brand M D

  Gene; 2008 Mar 31. 411 (40545):69-76.

• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27 (2):433-446.

Immunology

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• Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

  Kidani Y, Elsaesser H, Hock M B, Vergnes L, Williams K J, Argus J P, Marbois B N, Komisopoulou E, Wilson E B, Osborne T F, Graeber T G, Reue K, Brooks D G and Bensinger S J

  Nature immunology; 2013 May 1. 14 (5):489-499.

• The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

  Henao-Mejia J, Williams A, Goff L A, Staron M, Licona-Limon P, Kaech S M, Nakayama M, Rinn J L and Flavell R A

  Immunity. 2013 Apr 24; [Epub ahead of print].

• Methods for assessing mitochondrial function in diabetes

  Perry C G, Kane D A, Lanza I R and Neufer P D

  Diabetes; 2013 Apr 1. 62 (4):1041-1053.

• Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3

  Li L, Zhang J, Yang Y, Wang Q, Gao L, Chang T, Zhang X, Xiang G, Cao Y, Shi Z, Zhao M and Gao G

  Nanoscale Res Lett; 2013 Feb 22. 8 (1):100.

• Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

  Sena L A, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman D A, Wang C R, Schumacker P T, Licht J D, Perlman H, Bryce P J and Chandel N S

  Immunity; 2013 Feb 21. 38 (2):225-236.

• Mitochondrial dysfunction in osteoarthritis is associated with a down-regulation of superoxide dismutase 2

  Gavriilidis C, Miwa S, von Zglinicki T, Taylor R W and Young D A

  Arthritis Rheum; 2013 Feb 1. 65 (2):378-87.

• Stomatin-like Protein 2 Deficiency in T Cells Is Associated with Altered Mitochondrial Respiration and Defective CD4+ T Cell Responses

  Christie D A, Mitsopoulos P, Blagih J, Dunn S D, St-Pierre J, Jones R G, Hatch G M and Madrenas J

  J Immunol; 2012 Nov 1. 189 (9):4349-4360.

• Commitment to glycolysis sustains survival of nitric oxide-producing inflammatory dendritic cells

  Everts B, Amiel E, van der Windt G J, Freitas T C, Chott R, Yarasheski K E, Pearce E L and Pearce E J

  Blood; 2012 Aug 16. 120 (7):1422-31.

• The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

  Haschemi A, Kosma P, Gille L, Evans C R, Burant C F, Starkl P, Knapp B, Haas R, Schmid J A, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik J A, Otterbein L E and Wagner O

  Cell Metab; 2012 Jun 6. 15 (6):813-826.

• Disruption of fnip1 reveals a metabolic checkpoint controlling B lymphocyte development

  Park H, Staehling K, Tsang M, Appleby M W, Brunkow M E, Margineantu D, Hockenbery D M, Habib T, Liggitt H D, Carlson G and Iritani B M

  Immunity; 2012 May 25. 36 (5):769-781.

• Mitochondria Distinguish Granule-Stored from de novo Synthesized Tumor Necrosis Factor Secretion in Human Mast Cells

  Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos K D, Angelidou A, Shirihai O and Theoharides T C

  Int Arch Allergy Immunol; 2012 Apr 27. 159 (1):23-32.

• Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

  Shimada K, Crother T R, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan V K, Wolf A J, Vergnes L, Ojcius D M, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald K A, Underhill D M, Town T and Arditi M

  Immunity; 2012 Mar 23. 36 (3):401-14.

• Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development

  van der Windt G J, Everts B, Chang C H, Curtis J D, Freitas T C, Amiel E, Pearce E J and Pearce E L

  Immunity; 2012 Jan 27. 36 (1):38-78.

• The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

  Wang R, Dillon C P, Shi L Z, Milasta S, Carter R, Finkelstein D, McCormick L L, Fitzgerald P, Chi H, Munger J and Green D R

  Immunity; 2011 Dec 23. 35 (6):871-882.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

  Bulua A C, Simon A, Maddipati R, Pelletier M, Park H, Kim K Y, Sack M N, Kastner D L and Siegel R M

  J Exp Med; 2011 Mar 14. 208 (3):519-533.

• Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

  Benitez A C, Dai Z, Mann H H, Reeves R S, Margineantu D H, Gooley T A, Groh V and Spies T

  Proc Natl Acad Sci U S A; 2011 Mar 8. 108 (10):4081-4086.

• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  Gurumurthy S, Xie S Z, Alagesan B, Kim J, Yusuf R Z, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park P J, Shirihai O S, Scadden D T and Bardeesy N

  Nature; 2010 Dec 2. 468 (7324):659-663.

• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

  Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro J B, Adelmant G O, Marto J A, Rhee K, Tisdale S, Danial N, Benarafa C, Orduna A and Anderson P

  Biochem Biophys Res Commun; 2010 Oct 22. 401 (3):440-446.

• HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

  Capasso M, Bhamrah M K, Henley T, Boyd R S, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny V V, Morgan D, Gascoyne R D, Vigorito E, DeCoursey T E, MacLennan I C and Dyer M J

  Nat Immunol; 2010 Mar 1. 11 (3):265-272.

Mitochondrial Diseases

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• Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion

  Cherry A B, Gagne K E, McLoughlin E M, Baccei A, Gorman B, Hartung O, Miller J D, Zhang J, Zon R L, Ince T A, Neufeld E J, Lerou P H, Fleming M D, Daley G Q and Agarwal S

  Stem Cells. 2013 Feb 8; [Epub ahead of print].

• Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings

  Haack T B, Rolinski B, Haberberger B, Zimmermann F, Schum J, Strecker V, Graf E, Athing U, Hoppen T, Wittig I, Sperl W, Freisinger P, Mayr J A, Strom T M, Meitinger T and Prokisch H

  J Inherit Metab Dis; 2013 Jan 1. 36 (1):55-62.

• Mouse mtDNA mutant model of Leber hereditary optic neuropathy

  Lin C S, Sharpley M S, Fan W, Waymire K G, Sadun A A, Carelli V, Ross-Cisneros F N, Baciu P, Sung E, McManus M J, Pan B X, Gil D W, Macgregor G R and Wallace D C

  Proc Natl Acad Sci U S A; 2012 Dec 4. 109 (49):20065-70.

• Mutations in COX7B Cause Microphthalmia with Linear Skin Lesions, an Unconventional Mitochondrial Disease

  Indrieri A, van Rahden V A, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M and Franco B

  Am J Hum Genet; 2012 Nov 2. 91 (5):942-949.

• Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

  Ghezzi D, Baruffini E, Haack T B, Invernizzi F, Melchionda L, Dallabona C, Strom T M, Parini R, Burlina A B, Meitinger T, Prokisch H, Ferrero I and Zeviani M

  Am J Hum Genet; 2012 Jun 8. 90 (6):1079-87.

• Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations

  Steenweg M E, Ghezzi D, Haack T, Abbink T E, Martinelli D, van Berkel C G, Bley A, Diogo L, Grillo E, Te Water Naude J, Strom T M, Bertini E, Prokisch H, van der Knaap M S and Zeviani M

  Brain; 2012 May 1. 135 (Pt 5):1387-94.

• Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts

  Richardson T E, Yu A E, Wen Y, Yang S-H and Simpkins J W

  PLoS One; 2012 Apr 3. 7 (4):e34600.

• Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing

  Haack T B, Haberberger B, Frisch E M, Wieland T, Iuso A, Gorza M, Strecker V, Graf E, Mayr J A, Herberg U, Hennermann J B, Klopstock T, Kuhn K A, Ahting U, Sperl W, Wilichowski E, Hoffmann G F, Tesarova M, Hansikova H, Zeman J, Plecko B, Zeviani M, Wittig I, Strom T M, Schuelke M, Freisinger P, Meitinger T and Prokisch H

  J Med Genet; 2012 Apr 1. 49 (4):277-283.

• Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

  Invernizzi F, D'Amato I, Jensen P B, Ravaglia S, Zeviani M and Tiranti V

  Mitochondrion; 2012 Mar 1. 12 (2):328-35.

• Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

  Raimundo N, Song L, Shutt T E, McKay S E, Cotney J, Guan M X, Gilliland T C, Hohuan D, Santos-Sacchi J and Shadel G S

  Cell; 2012 Feb 17. 148 (4):716-726.

• Mitochondrial dysfunction in ataxia telangiectasia

  Valentin-Vega Y A, Maclean K H, Tait-Mulder J, Milasta S, Steeves M, Dorsey F C, Cleveland J L, Green D R and Kastan M B

  Blood; 2012 Feb 9. 119 (6):1490-500.

• Partial tandem duplication of mtDNA-tRNA(Phe) impairs mtDNA translation in late-onset mitochondrial myopathy

  Arzuffi P, Lamperti C, Fernandez-Vizarra E, Tonin P, Morandi L and Zeviani M

  Neuromuscul Disord; 2012 Jan 1. 22 (1):50-55.

• The effects of idebenone on mitochondrial bioenergetics

  Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G and Bernardi P

  Biochimica et Biophysica Acta (BBA) - Bioenergetics; 2011 Nov 4.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

  Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C and Zeviani M

  Nat Genet; 2011 Mar 1. 43 (3):259-263.

• Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts

  Moran M, Rivera H, Sanchez-Arago M, Blazquez A, Merinero B, Ugalde C, Arenas J, Cuezva J M and Martin M A

  Biochim Biophys Acta; 2010 May 1. 1802 (5):443-453.

• Mitochondrial and nuclear genomic responses to loss of LRPPRC expression

  Gohil V M, Nilsson R, Belcher-Timme C A, Luo B, Root D E and Mootha V K

  J Biol Chem; 2010 Apr 30. 285 (18):13742-13747.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Model Organisms

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• Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis

  Segear Johnson E, Lindblom K R, Robeson A, Stevens R D, Ilkayeva O R, Newgard C B, Kornbluth S and Andersen J L

  J Biol Chem.. 2013 Apr 3; [Epub ahead of print].

• Opa1 is required for proper mitochondrial metabolism in early development

  Rahn J J, Stackley K D and Chan S S

  PLoS One; 2013 Mar 14. 8 (3):e59218.

• The impact of mitochondrial and thermal stress on the bioenergetics and reserve respiratory capacity of fish cell lines

  Beck B H and Fuller S A

  J Aquat Anim Health; 2012 Dec 1. 24 (4):244-250.

• Fatty Acid Oxidation Is Essential for Egg Production by the Parasitic Flatworm Schistosoma mansoni

  Huang S C, Freitas T C, Amiel E, Everts B, Pearce E L, Lok J B and Pearce E J

  PLoS Pathog; 2012 Oct 1. 8 (10):e1002996.

• Expression Profiling of Attenuated Mitochondrial Function Identifies Retrograde Signals in Drosophila

  Freije W A, Mandal S and Banerjee U

  G3: Genes|Genomes|Genetics; 2012 Aug 1. 2 (8):843-851.

• Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships

  Pathare P P, Lin A, Bornfeldt K E, Taubert S and Van Gilst M R

  PLoS Genet; 2012 Apr 1. 8 (4):e1002645.

• GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling

  Willaert A, Khatri S, Callewaert B L, Coucke P J, Crosby S D, Lee J G, Davis E C, Shiva S, Tsang M, De Paepe A and Urban Z

  Hum Mol Genet; 2012 Mar 15. 21 (6):1248-59.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• Bioenergetic profiling of zebrafish embryonic development

  Stackley K D, Beeson C C, Rahn J J and Chan S S

  PLoS One; 2011 Sep 29. 6 (9):e25652.

• A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

  Pei W, Kratz L E, Bernardini I, Sood R, Yokogawa T, Dorward H, Ciccone C, Kelley R I, Anikster Y, Burgess H A, Huizing M and Feldman B

  Development; 2010 Aug 1. 137 (15):2587-2596.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Nephrology

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• Role of mitofusin 2 in the renal stress response

  Gall J M, Wang Z, Liesa M, Molina A, Havasi A, Schwartz J H, Shirihai O, Borkan S C and Bonegio R G

  PLoS One; 2012 Jan 26. 7 (1):e31074.

• Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

  Szoleczky P, Modis K, Nagy N, Toth Z D, Dewitt D, Szabo C and Gero D

  Arch Biochem Biophys; 2012 Jan 1. 517 (1):53-70.

• SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

  Koyama T, Kume S, Koya D, Araki S I, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H and Uzu T

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1258-1267.

• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

  Tong W H, Sourbier C, Kovtunovych G, Jeong S Y, Vira M, Ghosh M, Romero V V, Sougrat R, Vaulont S, Viollet B, Kim Y S, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan W M and Rouault T A

  Cancer Cell; 2011 Sep 13. 20 (3):315-327.

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

Neurodegeneration

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• Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells

  Im A R, Kim Y H, Uddin M R, Chae S, Lee H W, Kim Y S and Lee M Y

  Cell Mol Neurobiol. 2013 Apr 20; [Epub ahead of print].

• The role of CSA and CSB protein in the oxidative stress response

  D'Errico M, Pascucci B, Lorio E, Van Houten B and Dogliotti E

  Mech Ageing Dev. 2013 Apr 3; [Epub ahead of print].

• Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

  Voloboueva L A, Emery J F, Sun X and Giffard R G

  FEBS Lett; 2013 Mar 18. 587 (6):756-62.

• Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3

  Li L, Zhang J, Yang Y, Wang Q, Gao L, Chang T, Zhang X, Xiang G, Cao Y, Shi Z, Zhao M and Gao G

  Nanoscale Res Lett; 2013 Feb 22. 8 (1):100.

• Potentiation of brain mitochondrial function by S-equol and R/S-equol Estrogen Receptor beta selective phytoSERM treatments

  Yao J, Zhao L, Mao Z, Chen S, Wong K, To J and Brinton R D

  Brain Res. 2013 Feb 18; [Epub ahead of print].

• Metabolism of 1-Methyl-4-phenyl-1-2-3-6-tetrahydropyridine by Mitochondria-targeted Cytochrome P450 2D6: Implications in Parkinson's Disease

  Bajpai P, Sangar M C, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang J K, Martin M V, Guengerich F P and Avadhani N G

  J Biol Chem; 2013 Feb 8. 288 (6):4436-51.

• Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death

  Perron N R, Beeson C and Rohrer B

  J Bioenerg Biomembr; 2013 Feb 1. 45 (1-2):101-9.

• Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression

  Cronin-Furman E N, Borland M K, Bergquist K E, Bennett J P, Jr. and Trimmer P A

  Mol Neurodegener; 2013 Jan 26. 8 (1):6.

• Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal

  Singh I N, Gilmer L K, Miller D M, Cebak J E, Wang J A and Hall E D

  J Cereb Blood Flow Metab. 2013 Jan 16; [Epub ahead of print].

• Blocking c-jun-N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-hydroxydopamine-induced Toxicity in vitro and in vivo

  Chambers J W, Howard S and Lograsso P V

  J Biol Chem; 2013 Jan 11. 288 (2):1079-87.

• Glycolysis-respiration relationships in a neuroblastoma cell line

  Swerdlow R H, Lezi E, Aires D and Lu J

  Biochim Biophys Acta; 2013 Jan 10. 1830 (4):2891-2898.

• Effect of Cholinergic Signaling on Neuronal Cell Bioenergetics

  Lu J, E L, Roy N, Hutfles L, Selfridge E, Funk E, Burns J M and Swerdlow R H

  J Alzheimers Dis; 2013 Jan 1. 33 (4):1135-46.

• Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF

  Gouarne C, Giraudon-Paoli M, Seimandi M, Biscarrat C, Tardif G, Pruss R M and Bordet T

  Br J Pharmacol. 2012 Dec 28; [Epub ahead of print].

• Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo

  Miller D M, Singh I N, Wang J A and Hall E D

  Free Radic Biol Med; 2012 Dec 27. 57C (1)

• Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

  Brunetti D, Dusi S, Morbin M, Uggetti A, Moda F, D'Amato I, Giordano C, d'Amati G, Cozzi A, Levi S, Hayflick S and Tiranti V

  Hum Mol Genet; 2012 Dec 15. 21 (24):5294-305.

• Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse Extracellular Flux XF24 Analysis

  Lange M L, Zeng Y, Knight A, Windebank A and Trushina E

  Frontiers in Neurology; 2012 Dec 14. 3 (175)

• Alteration of Fatty-Acid-Metabolizing Enzymes Affects Mitochondrial Form and Function in Hereditary Spastic Paraplegia

  Tesson C, Nawara M, Salih M A, Rossignol R, Zaki M S, Al Balwi M, Schule R, Mignot C, Obre E, Bouhouche A, Santorelli F M, Durand C M, Oteyza A C, El-Hachimi K H, Al Drees A, Bouslam N, Lamari F, Elmalik S A, Kabiraj M M, Seidahmed M Z, Esteves T, Gaussen M, Monin M L, Gyapay G, Lechner D, Gonzalez M, Depienne C, Mochel F, Lavie J, Schols L, Lacombe D, Yahyaoui M, Al Abdulkareem I, Zuchner S, Yamashita A, Benomar A, Goizet C, Durr A, Gleeson J G, Darios F, Brice A and Stevanin G

  Am J Hum Genet; 2012 Dec 7. 91 (6):1051-64.

• Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

  Song L, Shan Y, Lloyd K C and Cortopassi G A

  Hum Mol Genet; 2012 Dec 1. 21 (23):5147-58.

• Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells

  Lopert P, Day B J and Patel M

  PLoS One; 2012 Nov 30. 7 (11):e50683.

• Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

  Xun Z, Rivera-Sanchez S, Ayala-Pena S, Lim J, Budworth H, Skoda E M, Robbins P D, Niedernhofer L J, Wipf P and McMurray C T

  Cell Rep; 2012 Nov 29. 2 (5):1137-42.

• No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease

  Choi S W, Gerencser A A, Ng R, Flynn J M, Melov S, Danielson S R, Gibson B W, Nicholls D G, Bredesen D E and Brand M D

  J Neurosci; 2012 Nov 21. 32 (47):16775-16784.

• Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

  Zhao W, Varghese M, Vempati P, Dzhun A, Cheng A, Wang J, Lange D, Bilski A, Faravelli I and Pasinetti G M

  PLoS One; 2012 Nov 7. 7 (11):e49191.

• Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/ref-1) is an indicator of energy disruption in neurons

  Singh S and Englander E W

  Free Radic Biol Med; 2012 Nov 1. 53 (9):1782-90.

• Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 premutation mouse model

  Kaplan E S, Cao Z, Hulsizer S, Tassone F, Berman R F, Hagerman P J and Pessah I N

  J Neurochem; 2012 Nov 1. 123 (4):613-21.

• Neuroprotective actions of methylene blue and its derivatives

  Poteet E, Winters A, Yan L J, Shufelt K, Green K N, Simpkins J W, Wen Y and Yang S H

  PLoS One; 2012 Oct 31. 7 (10):e48279.

• Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro

  Steketee M B, Moysidis S N, Weinstein J E, Kreymerman A, Silva J P, Iqbal S and Goldberg J L

  Invest Ophthalmol Vis Sci; 2012 Oct 30. 53 (11):7402-7411.

• Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

  Anne Stetler R, Leak R K, Yin W, Zhang L, Wang S, Gao Y and Chen J

  Journal of Neurochemistry. 2012 Oct 11; [Epub ahead of print].

• Methylene blue as a cerebral metabolic and hemodynamic enhancer

  Lin A L, Poteet E, Du F, Gourav R C, Liu R, Wen Y, Bresnen A, Huang S, Fox P T, Yang S H and Duong T Q

  PLoS One; 2012 Oct 9. 7 (10):e46585.

• Mitochondrial DNA damage Is associated with reduced mitochondrial bioenergetics in Huntington's disease

  Siddiqui A, Rivera-Sánchez S, Castro M d R, Acevedo-Torres K, Rane A, Torres-Ramos C A, Nicholls D G, Andersen J K and Ayala-Torres S

  Free Radic Biol Med; 2012 Oct 1. 53 (7):1478-88.

• Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

  Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper R H, Auwerx J, Franken P and Tafti M

  J Neurosci; 2012 Sep 5. 32 (36):12506-12517.

• Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: Lack of correlation with superoxide generation

  Dranka B P, Zielonka J, Kanthasamy A G and Kalyanaraman B

  J Neurochem; 2012 Sep 1. 122 (5):941-51.

• Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

  Walls K C, Coskun P, Gallegos-Perez J L, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green K N and Laferla F M

  J Biol Chem; 2012 Aug 31. 287 (36):30317-30327.

• Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

  Siddiqui A, Chinta S J, Mallajosyula J K, Rajagopolan S, Hanson I, Rane A and Andersen J K

  Free Radical Biology and Medicine; 2012 Aug 15. 53 (4):993-1003.

• Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

  An M C, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S and Ellerby L M

  Cell Stem Cell; 2012 Aug 3. 11 (2):253-63.

• Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid

  Yao J, Irwin R, Chen S, Hamilton R, Cadenas E and Brinton R D

  Neurobiol Aging; 2012 Aug 1. 33 (8):1507-1521.

• Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

  Giaime E, Yamaguchi H, Gautier C A, Kitada T and Shen J

  PLoS One; 2012 Jul 9. 7 (7):e40501.

• Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

  Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean J R, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti R J, Huang Z, Opala G, Scarffe L A, Dawson V L, Klein C, Feng J, Ross O A, Trojanowski J Q, Lee V M, Marder K, Surmeier D J, Wszolek Z K, Przedborski S, Krainc D, Dawson T M and Isacson O

  Sci Transl Med; 2012 Jul 4. 4 (141):141ra190.

• Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

  Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon V P, Bixby J L, Gereben B and Bianco A C

  The Journal of Neuroscience; 2012 Jun 20. 32 (25):8491-8500.

• Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

  Roy Chowdhury S K, Smith D R, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N A and Fernyhough P

  Brain; 2012 Jun 1. 135 (Pt 6):1751-66.

• Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP(+) toxicity: dual roles for ERK1/2

  Zhu J H, Gusdon A M, Cimen H, Van Houten B, Koc E and Chu C T

  Cell Death Dis; 2012 May 24. 3 (e312)

• BAD-Dependent Regulation of Fuel Metabolism and K(ATP) Channel Activity Confers Resistance to Epileptic Seizures

  Gimenez-Cassina A, Martinez-Francois J R, Fisher J K, Szlyk B, Polak K, Wiwczar J, Tanner G R, Lutas A, Yellen G and Danial N N

  Neuron; 2012 May 24. 74 (4):719-730.

• Sustained expression of PGC-1alpha in the rat nigrostriatal system selectively impairs dopaminergic function

  Ciron C, Lengacher S, Dusonchet J, Aebischer P and Schneider B L

  Hum Mol Genet; 2012 Apr 15. 21 (8):1861-76.

• Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

  Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P C, Minor R K, Wilson Iii D M, Cooper M, Spencer R, de Cabo R, Croteau D L and Bohr V A

  J Exp Med; 2012 Apr 9. 209 (4):855-869.

• Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

  Clerc P and Polster B M

  PLoS One; 2012 Apr 4. 7 (3):e34465.

• Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts

  Richardson T E, Yu A E, Wen Y, Yang S-H and Simpkins J W

  PLoS One; 2012 Apr 3. 7 (4):e34600.

• Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency

  Alavian K N, Dworetzky S I, Bonanni L, Zhang P, Sacchetti S, Mariggio M A, Onofrj M, Thomas A, Li H, Mangold J E, Signore A P, Demarco U, Demady D R, Nabili P, Lazrove E, Smith P J, Gribkoff V K and Jonas E A

  Brain Res; 2012 Mar 29. (1446):1-11.

• Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

  Sauerbeck A, Hunter R, Bing G and Sullivan P G

  Exp Neurol; 2012 Mar 1. 234 (1):85-94.

• Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

  Liang L P, Waldbaum S, Rowley S, Huang T T, Day B J and Patel M

  Neurobiol Dis; 2012 Mar 1. 45 (3):1068-76.

• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

  Gusdon A M, Zhu J, Van Houten B and Chu C T

  Neurobiol Dis; 2012 Mar 1. 45 (3):962-72.

• Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function

  Irwin R W, Yao J, To J, Hamilton R T, Cadenas E and Brinton R D

  J Neuroendocrinol; 2012 Jan 1. 24 (1):236-248.

• Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

  Schuh R A, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H and Polster B M

  J Neurosci Res; 2011 Dec 1. 89 (12):1979-1988.

• Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

  Schneider L, Giordano S, Zelickson B R, Johnson M, Benavides G, Ouyang X, Fineberg N, Darley-Usmar V M and Zhang J

  Free Radical Biology and Medicine; 2011 Dec 1. 51 (11):2007-17.

• Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

  Dagda R K, Gusdon A M, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra S J, 3rd and Chu C T

  Cell Death Differ; 2011 Dec 1. 18 (12):1914-23.

• DJ-1 knock-down impairs astrocyte mitochondrial function

  Larsen N J, Ambrosi G, Mullett S J, Berman S B and Hinkle D A

  Neuroscience; 2011 Nov 24. (196):251-64.

• DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

  McGee S L, Sadli N, Morrison S, Swinton C and Suphioglu C

  Cell Physiol Biochem; 2011 Aug 26. 28 (1):157-162.

• 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

  Yao J, Chen S, Mao Z, Cadenas E and Brinton R D

  PLoS One; 2011 Jul 1. 6 (7):e21788.

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H(2) O(2)

  Cantu D, Fulton R E, Drechsel D A and Patel M

  J Neurochem; 2011 Jul 1. 118 (1):79-92.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

  Wen Y, Li W, Poteet E C, Xie L, Tan C, Yan L J, Ju X, Liu R, Qian H, Marvin M A, Goldberg M S, She H, Mao Z, Simpkins J W and Yang S H

  J Biol Chem; 2011 May 6. 286 (18):16504-16515.

• Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

  Flynn J M, Choi S W, Day N U, Gerencser A A, Hubbard A and Melov S

  Free Radic Biol Med; 2011 Apr 1. 50 (7):866-873.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: Antagonism by progesterone

  Yao J, Chen S, Cadenas E and Brinton R D

  Brain Res; 2011 Mar 16. 1379 (1):40584.

• Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system

  Sauerbeck A, Pandya J, Singh I, Bittman K, Readnower R, Bing G and Sullivan P

  Journal of Neuroscience Methods; 2011 Mar 15. 198 (1):36-43.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

  Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C and Zeviani M

  Nat Genet; 2011 Mar 1. 43 (3):259-263.

• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

  Chen H K, Ji Z S, Dodson S E, Miranda R D, Rosenblum C I, Reynolds I J, Freedman S B, Weisgraber K H, Huang Y and Mahley R W

  J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.

• Meclizine is neuroprotective in models of Huntington's disease

  Gohil V M, Offner N, Walker J A, Sheth S A, Fossale E, Gusella J F, Macdonald M E, Neri C and Mootha V K

  Hum Mol Genet; 2011 Jan 15. 20 (2):294-300.

• Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction

  Kim Y H, Lussier S, Rane A, Choi S W and Andersen J K

  Neuroscience; 2011 Jan 13. 172 (1):379-386.

• Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

  Varghese M, Zhao W, Wang J, Cheng A, Qian X, Chaudhry A, Ho L and Pasinetti G

  Translational Neuroscience; 2011 Jan 5. 2 (1)

• KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

  Brustovetsky T, Brittain M K, Sheets P L, Cummins T R, Pinelis V and Brustovetsky N

  Br J Pharmacol; 2011 Jan 1. 162 (1):255-270.

• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

  Irwin R W, Yao J, Ahmed S S, Hamilton R T, Cadenas E and Brinton R D

  Endocrinology; 2010 Dec 15. 152 (2):556-567.

• Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration

  Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P and Nicotera P

  Hum Mol Genet; 2010 May 1. 19 (9):1669-1677.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

  Swerdlow R H

  Pharmaceuticals; 2009 Dec 3. 2 (3):150-167.

• Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

  Yao J, Irwin R W, Zhao L, Nilsen J, Hamilton R T and Brinton R D

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14670-14675.

• Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

  Choi S W, Gerencser A A and Nicholls D G

  J Neurochem; 2009 May 1. 109 (4):1179-1191.

Obesity, Diabetes & Metabolic Disorders

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• Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

  Cypess A M, White A P, Vernochet C, Schulz T J, Xue R, Sass C A, Huang T L, Roberts-Toler C, Weiner L S, Sze C, Chacko A T, Deschamps L N, Herder L M, Truchan N, Glasgow A L, Holman A R, Gavrila A, Hasselgren P O, Mori M A, Molla M and Tseng Y H

  Nat Med; 2013 May 1. 19 (5):635-639.

• Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKK[beta]

  Iseli T J, Turner N, Zeng X-Y, Cooney G J, Kraegen E W, Yao S, Ye Y, James D E and Ye J-M

  PloS one; 2013 Apr 25. 8 (4):e62309.

• TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

  Settembre C, De Cegli R, Mansueto G, Saha P K, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jurgen Klisch T, Wollenberg A C, Di Bernardo D, Chan L, Irazoqui J E and Ballabio A

  Nature cell biology. 2013 Apr 21; [Epub ahead of print].

• Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis

  Segear Johnson E, Lindblom K R, Robeson A, Stevens R D, Ilkayeva O R, Newgard C B, Kornbluth S and Andersen J L

  J Biol Chem.. 2013 Apr 3; [Epub ahead of print].

• Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

  Divakaruni A S, Wiley S E, Rogers G W, Andreyev A Y, Petrosyan S, Loviscach M, Wall E A, Yadava N, Heuck A P, Ferrick D A, Henry R R, McDonald W G, Colca J R, Simon M I, Ciaraldi T P and Murphy A N

  Proc Natl Acad Sci U S A; 2013 Apr 2. 110 (14):5422-7.

• Ablation of Dihydroceramide Desaturase-1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

  Siddique M M, Ying L, Wang L, Jianhong C, Mal M, Ilkayeva O, Wu Y J, Bay B H and Summers S A

  Mol Cell Biol. 2013 Apr 1; [Epub ahead of print].

• Methods for assessing mitochondrial function in diabetes

  Perry C G, Kane D A, Lanza I R and Neufer P D

  Diabetes; 2013 Apr 1. 62 (4):1041-1053.

• Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

  Bachar-Wikstrom E, Wikstrom J D, Ariav Y, Tirosh B, Kaiser N, Cerasi E and Leibowitz G

  Diabetes; 2013 Apr 1. 62 (4):1227-1237.

• Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation

  Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron A C, Kopp J, Yamamoto M and Noguchi C T

  Int J Biochem Cell Biol; 2013 Mar 20.

• Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

  Ryu M J, Kim S J, Kim Y K, Choi M J, Tadi S, Lee M H, Lee S E, Chung H K, Jung S B, Kim H J, Jo Y S, Kim K S, Lee S H, Kim J M, Kweon G R, Park K C, Lee J U, Kong Y Y, Lee C H, Chung J and Shong M

  PLoS Genet; 2013 Mar 14. 9 (3):e1003356.

• Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 beta-cells accompany functional adaptations to lipotoxicity

  Malmgren S, Spegel P, Danielsson A P, Nagorny C L, Andersson L E, Dekker Nitert M, Ridderstrale M, Mulder H and Ling C

  J Biol Chem. 2013 Mar 8; [Epub ahead of print].

• Rosemary (Rosmarinus officinalis L.) extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells

  Tu Z, Moss-Pierce T, Ford P and Jiang A

  J Agric Food Chem. 2013 Mar 6; [Epub ahead of print].

• Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARgamma Specifies Lipid Storage versus Thermogenic Gene Programs

  Villanueva C J, Vergnes L, Wang J, Drew B G, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener A L, Reue K, Fong L G, Young S G and Tontonoz P

  Cell Metab; 2013 Mar 5. 17 (3):423-435.

• Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

  Lee S H, Jouihan H A, Cooksey R C, Jones D, Kim H J, Winge D R and McClain D A

  Endocrinology; 2013 Mar 1. 154 (3):1029-1038.

• Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction

  Gero D, Szoleczky P, Suzuki K, Modis K, Olah G, Coletta C and Szabo C

  Diabetes; 2013 Mar 1. 62 (3):953-964.

• The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

  Chowdhury S K, Smith D R and Fernyhough P

  Neurobiol Dis; 2013 Mar 1.

• An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice

  Reilly S M, Chiang S H, Decker S J, Chang L, Uhm M, Larsen M J, Rubin J R, Mowers J, White N M, Hochberg I, Downes M, Yu R T, Liddle C, Evans R M, Oh D, Li P, Olefsky J M and Saltiel A R

  Nat Med. 2013 Feb 10; [Epub ahead of print].

• Knockdown of RyR3 Enhances Adiponectin Expression Through an atf3-Dependent Pathway

  Tsai S H, Chang E Y, Chang Y C, Hee S W, Tsai Y C, Chang T J and Chuang L M

  Endocrinology. 2013 Feb 6; [Epub ahead of print].

• Ciliary neurotrophic factor activates NF-kappaB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

  Saleh A, Roy Chowdhury S K, Smith D R, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi K E, Calcutt N A and Fernyhough P

  Neuropharmacology; 2013 Feb 1. 2013 Feb (65):65-73.

• Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet beta-Cells

  Nishiki Y, Adewola A, Hatanaka M, Templin A T, Maier B and Mirmira R G

  Mol Endocrinol; 2013 Feb 1. 27 (2):336-349.

• Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

  Liew C W, Boucher J, Cheong J K, Vernochet C, Koh H J, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng Y H, Hellerstein M K, Farmer S R, Goodyear L, Doria A, Bluher M, Hsu S I and Kulkarni R N

  Nat Med; 2013 Feb 1. 19 (2):217-26.

• Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

  Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot M L, Ruderman N B, Nolan C J, Joly E, Madiraju S R, Poitout V and Prentki M

  Diabetes. 2013 Feb 1; [Epub ahead of print].

• Novel cell-based assay reveals associations of circulating serum AhR-ligands with metabolic syndrome and mitochondrial dysfunction

  Park W-H, Jun D W, Kim J T, Jeong J H, Park H, Chang Y-S, Park K S, Lee H K and Pak Y K

  BioFactors. 2013 Jan 30; [Epub ahead of print].

• Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice from High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

  Camporez J P, Jornayvaz F R, Lee H Y, Kanda S, Guigni B A, Kahn M, Samuel V T, Carvalho C R, Petersen K F, Jurczak M J and Shulman G I

  Endocrinology. 2013 Jan 30; [Epub ahead of print].

• Central Glucagon-Like Peptide 1 Receptor (Glp1r)-Induced Anorexia Requires Glucose Metabolism-Mediated Suppression of AMPK and is Impaired by Central Fructose

  Burmeister M A, Ayala J E and Drucker D J

  Am J Physiol Endocrinol Metab. 2013 Jan 22; [Epub ahead of print].

• Essential Roles of 11beta-HSD1 in regulating brown adipocyte function

  Liu J, Kong X, Wang L, Qi H, Di W, Zhang X, Wu L, Chen X, Yu J, Zha J, Lv S, Zhang A, Cheng P, Hu M, Li Y, Bi J, Hu F, Zhong Y, Xu Y and Ding G

  J Mol Endocrinol; 2013 Jan 11. 50 (1):103-113.

• p62 Links beta-adrenergic input to mitochondrial function and thermogenesis

  Muller T D, Lee S J, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger K M, Hembree J, Heppner K M, Hofmann S, Holland J, Kuchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch A K, Schriever S C, Speakman J, Tseng Y H, Diaz-Meco M, Pfluger P T, Moscat J and Tschop M H

  J Clin Invest; 2013 Jan 2. 123 (1):469-478.

• Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

  Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin M J, An D, Lee K Y, Ilkayeva O R, Zingaretti C M, Emanuelli B, Smyth G, Cinti S, Newgard C B, Gibson B W, Larsson N G and Kahn C R

  Cell Metab; 2012 Dec 5. 16 (6):765-76.

• GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

  Tocchetti C G, Caceres V, Stanley B A, Xie C, Shi S, Watson W H, O'Rourke B, Spadari-Bratfisch R C, Cortassa S, Akar F G, Paolocci N and Aon M A

  Diabetes; 2012 Dec 1. 61 (12):3094-3105.

• Enhanced phosphoinositide 3-kinase(p110alpha) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

  Ritchie R H, Love J E, Huynh K, Bernardo B C, Henstridge D C, Kiriazis H, Tham Y K, Sapra G, Qin C, Cemerlang N, Boey E J, Jandeleit-Dahm K, Du X J and McMullen J R

  Diabetologia; 2012 Dec 1. 55 (12):3369-81.

• Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis

  Hagopian K, Tomilov A A, Tomilova N, Kim K, Taylor S L, Lam A K, Cortopassi G A, McDonald R B and Ramsey J J

  Metabolism; 2012 Dec 1. 61 (12):1703-13.

• Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

  Chao L C, Wroblewski K, Ilkayeva O R, Stevens R D, Bain J, Meyer G A, Schenk S, Martinez L, Vergnes L, Narkar V A, Drew B G, Hong C, Boyadjian R, Hevener A L, Evans R M, Reue K, Spencer M J, Newgard C B and Tontonoz P

  J Lipid Res; 2012 Dec 1. 53 (12):2610-9.

• Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

  Mailloux R J, Fu A, Robson-Doucette C, Allister E, Wheeler M B, Screaton R and Harper M E

  J Biol Chem; 2012 Nov 16. 287 (47):39673-85.

• MyomiR-133 regulates brown fat differentiation through Prdm16

  Trajkovski M, Ahmed K, Esau C C and Stoffel M

  Nat Cell Biol; 2012 Nov 11. 14 (12):1330-1335.

• Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

  Jantzen K, Roursgaard M, Desler C, Loft S, Rasmussen L J and Moller P

  Mutagenesis; 2012 Nov 1. 27 (6):693-701.

• Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells

  Vaughan R A, Garcia-Smith R, Bisoffi M, Conn C A and Trujillo K A

  Lipids Health Dis; 2012 Oct 30. 11 (1):142.

• Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat

  Teperino R, Amann S, Bayer M, McGee S L, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young R S, Febbraio M A, Knauf C, Cani P D, Aberger F, Penninger J M, Pospisilik J A and Esterbauer H

  Cell; 2012 Oct 12. 151 (2):414-426.

• Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype

  Sansbury B E, Cummins T D, Tang Y, Hellmann J, Holden C R, Harbeson M A, Chen Y, Patel R P, Spite M R, Bhatnagar A and Hill B G

  Circ Res; 2012 Oct 12. 111 (9):1176-89.

• Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

  Raichur S, Hooi Teh S, Ohwaki K, Gaur V, Chau Long Y, Hargreaves M, McGee S L and Kusunoki J

  J Mol Endocrinol; 2012 Oct 12. 49 (3):203-211.

• TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

  Su X, Gi Y J, Chakravarti D, Chan I L, Zhang A, Xia X, Tsai K Y and Flores E R

  Cell Metab; 2012 Oct 3. 16 (4):511-525.

• Role of TRIB3 in Regulation of Insulin Sensitivity and Nutrient Metabolism during Short-term Fasting and Nutrient Excess

  Liu J, Zhang W, Chuang G C, Hill H S, Tian L, Fu Y, Moellering D R and Garvey W T

  Am J Physiol Endocrinol Metab; 2012 Oct 1. 303 (7):E908-16.

• Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial beta-oxidation

  Gonzalez-Barroso M M, Anedda A, Gallardo-Vara E, Redondo-Horcajo M, Rodriguez-Sanchez L and Rial E

  Biochim Biophys Acta; 2012 Oct 1. 1817 (20):1768-75.

• Protein carbonylation and adipocyte mitochondrial function

  Curtis J M, Hahn W S, Stone M D, Inda J J, Droullard D J, Kuzmicic J P, Donoghue M A, Long E K, Armien A G, Lavandero S, Arriaga E, Griffin T J and Bernlohr D A

  J Biol Chem; 2012 Sep 21. 287 (39):32967-32980.

• Zbtb16 has a role in brown adipocyte bioenergetics

  Plaisier C L, Bennett B J, He A, Guan B, Lusis A J, Reue K and Vergnes L

  Nutr Diabetes; 2012 Sep 17. 2 (9):e46.

• MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

  Kusminski C M, Holland W L, Sun K, Park J, Spurgin S B, Lin Y, Askew G R, Simcox J A, McClain D A, Li C and Scherer P E

  Nat Med; 2012 Sep 9. 18 (10):1539-49.

• Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

  Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K and Saito M

  Cell Metab; 2012 Sep 5. 16 (3):394-406.

• Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting

  Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial N N, Watkins S M and Hotamisligil G S

  PLoS Genet; 2012 Aug 23. 8 (8):e1002902.

• Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Ppargamma

  Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer S R and Accili D

  Cell; 2012 Aug 3. 150 (3):620-632.

• Impact of high glucose and transforming growth factor-beta on bioenergetic profiles in podocytes

  Stieger N, Worthmann K, Teng B, Engeli S, Das A M, Haller H and Schiffer M

  Metabolism; 2012 Aug 1. 61 (8):1073-86.

• LRH-1-dependent glucose sensing determines intermediary metabolism in liver

  Oosterveer M H, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk T H, Ayuso E, Bosch F, Postic C, Groen A K, Auwerx J and Schoonjans K

  J Clin Invest; 2012 Aug 1. 122 (8):2817-26.

• Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

  Konstantopoulos N, Molero J C, McGee S L, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta V C, Krippner G, Andrikopoulos S and Walder K R

  Diabetes; 2012 Aug 1. 61 (8):2146-54.

• Acyl-CoA thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

  Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck C K, Genoud C, Cron P, Keusch J J, Dummler B, Esposti M D and Hemmings B A

  Mol Cell Biol; 2012 Jul 1. 32 (14):2685-97.

• Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

  Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung D Y, Ramsey J J, Kim J K, Cortopassi G, Havel P J and Haj F G

  Endocrinology; 2012 Jul 1. 153 (7):3158-3169.

• BNip3 regulates mitochondrial function and lipid metabolism in the liver.

  Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon M C, Hart J, Dorn G W, 2nd, Brady M J and Macleod K F

  Mol Cell Biol; 2012 Jul 1. 32 (13):2570-84.

• Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

  Fournier B, Murray B, Gutzwiller S, Marcaletti S, Marcellin D, Bergling S, Brachat S, Persohn E, Pierrel E, Bombard F, Hatakeyama S, Trendelenburg A-U, Morvan F, Richardson B, Glass D J, Lach-Trifilieff E and Feige J N

  Molecular and Cellular Biology; 2012 Jul 1. 32 (14):2871-2879.

• Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition

  Fink B D, Herlein J A, O'Malley Y and Sivitz W I

  PLoS One; 2012 Jun 22. 7 (6):e39430.

• Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats

  Betz M J, Bielohuby M, Mauracher B, Abplanalp W, Muller H H, Pieper K, Ramisch J, Tschop M H, Beuschlein F, Bidlingmaier M and Slawik M

  PLoS One; 2012 Jun 13. 7 (6):e38997.

• Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

  Roy Chowdhury S K, Smith D R, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N A and Fernyhough P

  Brain; 2012 Jun 1. 135 (Pt 6):1751-66.

• Cellular Responses to the Metal-Binding Properties of Metformin

  Logie L, Harthill J, Patel K, Bacon S, Hamilton D L, Macrae K, McDougall G, Wang H H, Xue L, Jiang H, Sakamoto K, Prescott A R and Rena G

  Diabetes; 2012 Jun 1. 61 (6):1423-33.

• Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

  Kiefer F W, Vernochet C, O'Brien P, Spoerl S, Brown J D, Nallamshetty S, Zeyda M, Stulnig T M, Cohen D E, Kahn C R and Plutzky J

  Nat Med; 2012 Jun 1. 18 (6):918-25.

• Peroxisome Proliferator-Activated Receptor gamma Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

  Hu S, Yao J, Howe A A, Menke B M, Sivitz W I, Spector A A and Norris A W

  Mol Endocrinol; 2012 Jun 1. 26 (6):977-988.

• Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

  Fernandez-Marcos P J, Jeninga E H, Canto C, Harach T, de Boer V C, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten S M, Schoonjans K and Auwerx J

  Sci Rep; 2012 May 28. 2 (425)

• A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

  Wikstrom J D, Sereda S B, Stiles L, Elorza A, Allister E M, Neilson A, Ferrick D A, Wheeler M B and Shirihai O S

  PLoS One; 2012 May 14. 7 (5):e33023.

• Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

  Urban M J, Pan P, Farmer K L, Zhao H, Blagg B S J and Dobrowsky R T

  Experimental Neurology; 2012 May 1. 235 (1):388-96.

• Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

  Sebastian D, Hernandez-Alvarez M I, Segales J, Sorianello E, Munoz J P, Sala D, Waget A, Liesa M, Paz J C, Gopalacharyulu P, Oresic M, Pich S, Burcelin R, Palacin M and Zorzano A

  Proc Natl Acad Sci U S A; 2012 Apr 3. 109 (14):5523-5528.

• Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships

  Pathare P P, Lin A, Bornfeldt K E, Taubert S and Van Gilst M R

  PLoS Genet; 2012 Apr 1. 8 (4):e1002645.

• Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes

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• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

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• A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

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• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

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• Mechanisms of metformin action on glucose transport and metabolism in human adipocytes

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• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

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• Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis

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• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

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• Respiration in adipocytes is inhibited by reactive oxygen species

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• C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

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• TGR5-mediated bile acid sensing controls glucose homeostasis

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• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

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• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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  EMBO J; 2008 Jan 23. 27 (2):433-446.

• Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

  Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva W S, Espinoza D, Faucette R, Barry K, Bianco A C and Patti M E

  J Biol Chem; 2007 May 25. 282 (21):15439-15450.

• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

  da-Silva W S, Harney J W, Kim B W, Li J, Bianco S D, Crescenzi A, Christoffolete M A, Huang S A and Bianco A C

  Diabetes; 2007 Mar 1. 56 (3):767-776.

• Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

  Watanabe M, Houten S M, Mataki C, Christoffolete M A, Kim B W, Sato H, Messaddeq N, Harney J W, Ezaki O, Kodama T, Schoonjans K, Bianco A C and Auwerx J

  Nature; 2006 Jan 26. 439 (7075):484-489.

Screening

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• Determination of Oxidoreductase Activity Using a High Throughput Microplate Respiratory Measurement

  Hommes G, Gasser C A, Ammann E M and Corvini P F

  Anal Chem; 2013 Jan 2. 85 (1):283-91.

• Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi

  Furtado C, Kunrath-Lima M, Rajao M A, Mendes I C, de Moura M B, Campos P C, Macedo A M, Franco G R, Pena S D, Teixeira S M, Van Houten B and Machado C R

  PLoS One; 2012 Aug 2. 7 (8):e42484.

• Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

  Nadanaciva S, Rana P, Beeson G C, Chen D, Ferrick D A, Beeson C C and Will Y

  J Bioenerg Biomembr; 2012 Aug 1. 44 (4):421-37.

• beta2 Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis

  Wills L P, Trager R E, Beeson G C, Lindsey C C, Peterson Y K, Beeson C C and Schnellmann R G

  J Pharmacol Exp Ther; 2012 Jul 1. 342 (1):106-18.

• A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

  Kitami T, Logan D J, Negri J, Hasaka T, Tolliday N J, Carpenter A E, Spiegelman B M and Mootha V K

  PLoS One; 2012 Mar 29. 7 (3):e33755.

• 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

  Kim Y I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N and Kawada T

  Mol Nutr Food Res; 2011 Apr 1. 55 (4):585-93.

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

  Baughman J M, Nilsson R, Gohil V M, Arlow D H, Gauhar Z and Mootha V K

  PLoS Genet; 2009 Aug 1. 5 (8):e1000590.

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

  Dykens J A, Jamieson J, Marroquin L, Nadanaciva S, Billis P A and Will Y

  Toxicol Appl Pharmacol; 2008 Dec 1. 233 (2):203-210.

• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

  Dykens J A, Jamieson J D, Marroquin L D, Nadanaciva S, Xu J J, Dunn M C, Smith A R and Will Y

  Toxicol Sci; 2008 Jun 1. 103 (2):335-345.

• Advances in measuring cellular bioenergetics using extracellular flux

  Ferrick D A, Neilson A and Beeson C

  Drug Discov Today; 2008 Mar 1. 13 (40669):268-274.

Stem Cell Biology

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• Enhanced tissue production through redox control in stem cell-laden hydrogels

  Reid B, Afzal J, McCartney A, Abraham R, O'Rourke B and Elisseeff J

  Tissue Eng Part A. 2013 Apr 30; [Epub ahead of print].

• Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

  Shen Y-A, Hung P-H, Chi W-H, Wang C-Y, Hsieh Y-T, Wei Y H and Chen Y-J

  Evidence-Based Complementary and Alternative Medicine. 2013 Mar 16; [Epub ahead of print].

• The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the Numb-p53 Complex

  Feldman D E, Chen C, Punj V and Machida K

  PLoS One; 2013 Feb 27. 8 (2):e57312.

• Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion

  Cherry A B, Gagne K E, McLoughlin E M, Baccei A, Gorman B, Hartung O, Miller J D, Zhang J, Zon R L, Ince T A, Neufeld E J, Lerou P H, Fleming M D, Daley G Q and Agarwal S

  Stem Cells. 2013 Feb 8; [Epub ahead of print].

• Cellular Bioenergetics is an Important Determinant of the Molecular Imaging Signal Derived from Luciferase and the Sodium-Iodide Symporter

  Chang C, Chan A, Lin X, Higuchi T, Terrovitis J, Afzal J M, Rittenbach A, Sun D, Vakrou S, Woldemichael K, O'Rourke B, Wahl R, Pomper M, Tsui B and Abraham M R

  Circ Res; 2013 Feb 1. 112 (3):441-50.

• Protein O-GlcNAcylation is a Novel Cytoprotective Signal in Cardiac Stem Cells

  Zafir A, Readnower R, Long B W, McCracken J, Aird A, Alvarez A, Cummins T D, Li Q, Hill B G, Bhatnagar A, Prabhu S D, Bolli R and Jones S P

  Stem Cells. 2013 Jan 17; [Epub ahead of print].

• Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation

  Yu W M, Liu X, Shen J, Jovanovic O, Pohl E E, Gerson S L, Finkel T, Broxmeyer H E and Qu C K

  Cell Stem Cell; 2013 Jan 3. 12 (1):62-74.

• Regulation of glycolysis by pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

  Takubo K, Nagamatsu G, Kobayashi C I, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson R S, Soga T, Hirao A, Suematsu M and Suda T

  Cell Stem Cell; 2013 Jan 3. 12 (1):49-61.

• Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

  Mantel C, Messina-Graham S, Moh A, Cooper S, Hangoc G, Fu X Y and Broxmeyer H E

  Blood; 2012 Sep 27. 120 (13):2589-99.

• Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

  An M C, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S and Ellerby L M

  Cell Stem Cell; 2012 Aug 3. 11 (2):253-63.

• Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

  Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean J R, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti R J, Huang Z, Opala G, Scarffe L A, Dawson V L, Klein C, Feng J, Ross O A, Trojanowski J Q, Lee V M, Marder K, Surmeier D J, Wszolek Z K, Przedborski S, Krainc D, Dawson T M and Isacson O

  Sci Transl Med; 2012 Jul 4. 4 (141):141ra190.

• Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

  Zhang J, Nuebel E, Wisidagama D R, Setoguchi K, Hong J S, Van Horn C M, Imam S S, Vergnes L, Malone C S, Koehler C M and Teitell M A

  Nat Protoc; 2012 Jun 1. 7 (6):1068-1085.

• Short-term calorie restriction enhances skeletal muscle stem cell function

  Cerletti M, Jang Y C, Finley L W, Haigis M C and Wagers A J

  Cell Stem Cell; 2012 May 4. 10 (5):515-519.

• Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

  Estrada J C, Albo C, Benguria A, Dopazo A, Lopez-Romero P, Carrera-Quintanar L, Roche E, Clemente E P, Enriquez J A, Bernad A and Samper E

  Cell Death Differ; 2012 May 1. 19 (5):743-55.

• HIFalpha induced switch from bivalent to exclusively glycolytic metabolism during ESC--EpiSC transition

  Zhou W, Choi M, Margineantu D, Margaretha L, Cavanaugh C, Blau C A, Horwitz M S, Hockenbery D M, Ware C and Ruohola-Baker H

  EMBO Journal; 2012 Mar 23. 31 (9):2103-16.

• Programming human pluripotent stem cells into white and brown adipocytes

  Ahfeldt T, Schinzel R T, Lee Y K, Hendrickson D, Kaplan A, Lum D H, Camahort R, Xia F, Shay J, Rhee E P, Clish C B, Deo R C, Shen T, Lau F H, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten R E, Rinn J L and Cowan C A

  Nat Cell Biol; 2012 Jan 15. 14 (2):209-19.

• The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

  Panopoulos A D, Yanes O, Ruiz S, Kida Y S, Diep D, Tautenhahn R, Herrerias A, Batchelder E M, Plongthongkum N, Lutz M, Berggren W T, Zhang K, Evans R M, Siuzdak G and Belmonte J C

  Cell Res; 2012 Jan 1. 22 (1):168-77.

• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

  Lee J Y, Takahashi N, Yasubuchi M, Kim Y I, Hashizaki H, Kim M J, Sakamoto T, Goto T and Kawada T

  Am J Physiol Cell Physiol; 2012 Jan 1. 302 (2):C463-472.

• Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

  Huang H P, Chen P H, Hwu W L, Chuang C Y, Chien Y H, Stone L, Chien C L, Li L T, Chiang S C, Chen H F, Ho H N, Chen C H and Kuo H C

  Hum Mol Genet; 2011 Dec 15. 20 (24):4851-64.

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

  Zhang J, Khvorostov I, Hong J S, Oktay Y, Vergnes L, Nuebel E, Wahjudi P N, Setoguchi K, Wang G, Do A, Jung H J, McCaffery J M, Kurland I J, Reue K, Lee W N, Koehler C M and Teitell M A

  EMBO J; 2011 Nov 15. 30 (24):4860-4873.

• Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells

  Tamai M, Yamashita A and Tagawa Y I

  J Biosci Bioeng; 2011 Nov 1. 112 (5):495-500.

• Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

  Tormos K V, Anso E, Hamanaka R B, Eisenbart J, Joseph J, Kalyanaraman B and Chandel N S

  Cell Metab; 2011 Oct 5. 14 (4):537-544.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• Mitochondria determine the differentiation potential of cardiac mesoangioblasts

  San Martin N, Cervera A M, Cordova C, Covarello D, McCreath K J and Galvez B G

  Stem Cells; 2011 Jul 1. 29 (7):1064-1074.

• Energy metabolism in human pluripotent stem cells and their differentiated counterparts

  Varum S, Rodrigues A S, Moura M B, Momcilovic O, Easley C A t, Ramalho-Santos J, Van Houten B and Schatten G

  PLoS One; 2011 Jun 17. 6 (6):e20914.

• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

Toxicology & Hepatobiology

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• Identification of the molecular basis of doxorubicin-induced cardiotoxicity

  Zhang S, Liu X, Bawa-Khalfe T, Lu L S, Lyu Y L, Liu L F and Yeh E T

  Nature medicine; 2013 Nov 1. 18 (11):1639-1642.

• Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

  Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agro A, Melino G and Willis A

  Cell Death Dis; 2013 Mar 21. 4:e549.

• Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase

  Quan H Y, Kim S J, Kim D Y, Jo H K, Kim G W and Chung S H

  Fitoterapia. 2013 Mar 14; [Epub ahead of print].

• Amphiphilic silver-delaminated clay nanohybrids and their composites with polyurethane: physico-chemical and biological evaluations

  Chi T-Y, Yeh H-Y, Lin J-J, Jeng U S and Hsu S-h

  J Mater Chem B; 2013 Mar 11. 1 (16):2178-2189.

• Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone

  Felser A, Blum K, Lindinger P W, Bouitbir J and Krahenbuhl S

  Toxicol Sci; 2013 Feb 1. 131 (2):480-490.

• Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null mice

  Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger W G, Schmelzle M, Usheva A, Tapper E B, Baffy G, Sukhatme V P, Wu Y and Robson S C

  Hepatology; 2013 Jan 1. 57 (1):205-16.

• An indole-derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice

  Park J H, Seo K S, Tadi S, Ahn B H, Lee J U, Heo J Y, Han J, Song M S, Kim S H, Yim Y H, Choi H S, Shong M and Kweon G R

  Antioxid Redox Signal. 2012 Nov 2; [Epub ahead of print].

• Characterization of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

  Rana P, Anson B, Engle S and Will Y

  Toxicol Sci; 2012 Nov 1. 130 (1):117-31.

• Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

  Jantzen K, Roursgaard M, Desler C, Loft S, Rasmussen L J and Moller P

  Mutagenesis; 2012 Nov 1. 27 (6):693-701.

• Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

  Pereira C V, Oliveira P J, Will Y and Nadanaciva S

  Toxicol Appl Pharmacol; 2012 Oct 15. 264 (2):167-81.

• Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype

  Sansbury B E, Cummins T D, Tang Y, Hellmann J, Holden C R, Harbeson M A, Chen Y, Patel R P, Spite M R, Bhatnagar A and Hill B G

  Circ Res; 2012 Oct 12. 111 (9):1176-89.

• Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

  Nadanaciva S, Rana P, Beeson G C, Chen D, Ferrick D A, Beeson C C and Will Y

  J Bioenerg Biomembr; 2012 Aug 1. 44 (4):421-37.

• BNip3 regulates mitochondrial function and lipid metabolism in the liver.

  Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon M C, Hart J, Dorn G W, 2nd, Brady M J and Macleod K F

  Mol Cell Biol; 2012 Jul 1. 32 (13):2570-84.

• Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

  Luo Y, Rana P and Will Y

  Toxicol Appl Pharmacol; 2012 Jun 1. 261 (2):172-80.

• Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

  Liu Y, Nguyen P, Baris T Z and Poirier M C

  Cardiovasc Toxicol; 2012 Jun 1. 12 (2):123-34.

• Additive Effects of Mitochondrion-targeted Cytochrome CYP2E1 and Alcohol Toxicity on Cytochrome c Oxidase Function and Stability of Respirosome Complexes

  Bansal S, Srinivasan S, Anandasadagopan S, Roy Chowdhury A, Selvaraj V, Kalyanaraman B, Joseph J and Avadhani N G

  J Biol Chem; 2012 May 4. 287 (19):15284-15297.

• Additive effects of mitochondria-targeted Cytochrome P4502E1 and alcohol toxicity on cytochrome c oxidase function and the stability of respirosome complexes

  Bansal S, Srinivasan S, Anandasadagopan S, Roy Chowdhury A, Selvaraj V, Kalyanaraman B, Joseph J and Avadhani N G

  J Biol Chem; 2012 May 4. 287 (19):15284-97.

• Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration

  Fernandez-Rojo M A, Restall C, Ferguson C, Martel N, Martin S, Bosch M, Kassan A, Leong G M, Martin S D, McGee S L, Muscat G E, Anderson R L, Enrich C, Pol A and Parton R G

  Hepatology; 2012 May 1. 55 (5):1574-84.

• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

  Higdon A N, Benavides G A, Chacko B K, Ouyang X, Johnson M S, Landar A, Zhang J and Darley-Usmar V M

  Am J Physiol Heart Circ Physiol; 2012 Apr 1. 302 (7):H1394-409.

• Ethanol Suppresses Ureagenesis in Rat Hepatocytes: Role of Acetaldehyde

  Holmuhamedov E L, Czerny C, Beeson C C and Lemasters J J

  J Biol Chem; 2012 Mar 2. 287 (10):7692-700.

• The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

  Thomas C E and Will Y

  Expert Opinion on Drug Discovery; 2012 Feb 1. 7 (2):109-122.

• Gene-dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia susceptible muscle

  Barrientos G C, Feng W, Truong K, Matthaei K I, Yang T, Allen P D, Lopez J R and Pessah I N

  J Biol Chem; 2012 Jan 20. 287 (4):2863-76.

• Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes

  Zelickson B R, Benavides G A, Johnson M S, Chacko B K, Venkatraman A, Landar A, Betancourt A M, Bailey S M and Darley-Usmar V M

  Biochim Biophys Acta; 2011 Dec 1. 1807 (12):1573-82.

• Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

  Mullen P J, Zahno A, Lindinger P, Maseneni S, Felser A, Krahenbuhl S and Brecht K

  Biochim Biophys Acta; 2011 Dec 1. 1813 (12):2079-87.

• Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells

  Tamai M, Yamashita A and Tagawa Y I

  J Biosci Bioeng; 2011 Nov 1. 112 (5):495-500.

• Molecular imaging of intracellular drug-membrane aggregate formation

  Baik J and Rosania G R

  Mol Pharm; 2011 Oct 3. 8 (5):1742-1749.

• Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells

  Xu Q, Vu H, Liu L, Wang T C and Schaefer W H

  J Biomol NMR; 2011 Apr 1. 49 (4-Mar):207-219.

• The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells

  Zahno A, Brecht K, Morand R, Maseneni S, Torok M, Lindinger P W and Krahenbuhl S

  Biochem Pharmacol; 2011 Feb 1. 81 (3):432-441.

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

  Dykens J A, Jamieson J, Marroquin L, Nadanaciva S, Billis P A and Will Y

  Toxicol Appl Pharmacol; 2008 Dec 1. 233 (2):203-210.

• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

  Dykens J A, Jamieson J D, Marroquin L D, Nadanaciva S, Xu J J, Dunn M C, Smith A R and Will Y

  Toxicol Sci; 2008 Jun 1. 103 (2):335-345.

• Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons

  Ferrick D, Wu M, Swift A L and Neilson A

  Drug-Induced Mitochondrial Dysfunction; 2008 Jan 22. :Ch 14.

Translational Medicine

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• Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

  Lopez-Erauskin J, Galino J, Ruiz M, Cuezva J M, Fabregat I, Cacabelos D, Boada J, Martinez J, Ferrer I, Pamplona R, Villarroya F, Portero-Otin M, Fourcade S and Pujol A

  Human molecular genetics; 2013 May 3.

• Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

  Kalantari-Dehaghi M, Chen Y, Deng W, Chernyavsky A, Marchenko S, Wang P H and Grando S A

  J Biol Chem. 2013 Apr 18; [Epub ahead of print].

• Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood

  Chacko B K, Kramer P A, Ravi S, Johnson M S, Hardy R W, Ballinger S W and Darley-Usmar V M

  Lab Invest. 2013 Mar 25; [Epub ahead of print].

• Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion

  Cherry A B, Gagne K E, McLoughlin E M, Baccei A, Gorman B, Hartung O, Miller J D, Zhang J, Zon R L, Ince T A, Neufeld E J, Lerou P H, Fleming M D, Daley G Q and Agarwal S

  Stem Cells. 2013 Feb 8; [Epub ahead of print].

• Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

  Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan N G, Forcales S, Puri P L, Leone T C, Marine J E, Calkins H, Kelly D P, Judge D P and Chen H S

  Nature; 2013 Feb 7. 494 (7435):105-110.

• Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings

  Haack T B, Rolinski B, Haberberger B, Zimmermann F, Schum J, Strecker V, Graf E, Athing U, Hoppen T, Wittig I, Sperl W, Freisinger P, Mayr J A, Strom T M, Meitinger T and Prokisch H

  J Inherit Metab Dis; 2013 Jan 1. 36 (1):55-62.

• Alteration of Fatty-Acid-Metabolizing Enzymes Affects Mitochondrial Form and Function in Hereditary Spastic Paraplegia

  Tesson C, Nawara M, Salih M A, Rossignol R, Zaki M S, Al Balwi M, Schule R, Mignot C, Obre E, Bouhouche A, Santorelli F M, Durand C M, Oteyza A C, El-Hachimi K H, Al Drees A, Bouslam N, Lamari F, Elmalik S A, Kabiraj M M, Seidahmed M Z, Esteves T, Gaussen M, Monin M L, Gyapay G, Lechner D, Gonzalez M, Depienne C, Mochel F, Lavie J, Schols L, Lacombe D, Yahyaoui M, Al Abdulkareem I, Zuchner S, Yamashita A, Benomar A, Goizet C, Durr A, Gleeson J G, Darios F, Brice A and Stevanin G

  Am J Hum Genet; 2012 Dec 7. 91 (6):1051-64.

• Importance of glycolysis and oxidative phosphorylation in advanced melanoma

  Ho J, de Moura M B, Lin Y, Vincent G, Thorne S, Duncan L M, Hui-Min L, Kirkwood J M, Becker D, Van Houten B and Moschos S J

  Mol Cancer; 2012 Oct 9. 11 (1):76.

• MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

  Muralimanoharan S, Maloyan A, Mele J, Guo C, Myatt L G and Myatt L

  Placenta; 2012 Oct 1. 33 (10):816-23.

• Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

  Konstantopoulos N, Molero J C, McGee S L, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta V C, Krippner G, Andrikopoulos S and Walder K R

  Diabetes; 2012 Aug 1. 61 (8):2146-54.

• Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan

  Hung C-L, Wu Y-J, Liu C-C, Chi B-C, Chang S-S, Wang L-Y, Yeh H-I and Wei Y-H

  International Journal of Gerontology; 2012 Jun 8. 6 (2):122-126.

• Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

  Ghezzi D, Baruffini E, Haack T B, Invernizzi F, Melchionda L, Dallabona C, Strom T M, Parini R, Burlina A B, Meitinger T, Prokisch H, Ferrero I and Zeviani M

  Am J Hum Genet; 2012 Jun 8. 90 (6):1079-87.

• An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

  Pascucci B, Lemma T, Iorio E, Giovannini S, Vaz B, Iavarone I, Calcagnile A, Narciso L, Degan P, Podo F, Roginskya V, Janjic B M, Van Houten B, Stefanini M, Dogliotti E and D'Errico M

  Aging Cell; 2012 Jun 1. 11 (3):520-29.

• Inhibiting Systemic Autophagy during Interleukin 2 (IL-2) Immunotherapy Promotes Long-term Tumor Regression

  Liang X, De Vera M E, Buchser W J, de Vivar Chavez A R, Loughran P, Stolz D B, Basse P, Wang T, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cancer Res; 2012 Jun 1. 72 (11):2791-801.

• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

  Hawley S A, Fullerton M D, Ross F A, Schertzer J D, Chevtzoff C, Walker K J, Peggie M W, Zibrova D, Green K A, Mustard K J, Kemp B E, Sakamoto K, Steinberg G R and Hardie D G

  Science; 2012 May 18. 336 (6083):918-22.

• Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations

  Steenweg M E, Ghezzi D, Haack T, Abbink T E, Martinelli D, van Berkel C G, Bley A, Diogo L, Grillo E, Te Water Naude J, Strom T M, Bertini E, Prokisch H, van der Knaap M S and Zeviani M

  Brain; 2012 May 1. 135 (Pt 5):1387-94.

• Measurement of mitochondrial respiration in trophoblast culture

  Maloyan A, Mele J, Muralimanohara B and Myatt L

  Placenta; 2012 May 1. 33 (5):456-8.

• Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing

  Haack T B, Haberberger B, Frisch E M, Wieland T, Iuso A, Gorza M, Strecker V, Graf E, Mayr J A, Herberg U, Hennermann J B, Klopstock T, Kuhn K A, Ahting U, Sperl W, Wilichowski E, Hoffmann G F, Tesarova M, Hansikova H, Zeman J, Plecko B, Zeviani M, Wittig I, Strom T M, Schuelke M, Freisinger P, Meitinger T and Prokisch H

  J Med Genet; 2012 Apr 1. 49 (4):277-283.

• Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

  Avila C, Huang R J, Stevens M V, Aponte A M, Tripodi D, Kim K Y and Sack M N

  Exp Clin Endocrinol Diabetes; 2012 Apr 1. 120 (4):248-51.

• Correcting human mitochondrial mutations with targeted RNA import

  Wang G, Shimada E, Zhang J, Hong J S, Smith G M, Teitell M A and Koehler C M

  Proc Natl Acad Sci U S A; 2012 Mar 27. 109 (13):4840-4845.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.

• Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

  Invernizzi F, D'Amato I, Jensen P B, Ravaglia S, Zeviani M and Tiranti V

  Mitochondrion; 2012 Mar 1. 12 (2):328-35.

• Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

  Raimundo N, Song L, Shutt T E, McKay S E, Cotney J, Guan M X, Gilliland T C, Hohuan D, Santos-Sacchi J and Shadel G S

  Cell; 2012 Feb 17. 148 (4):716-726.

• Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle

  Chen V, Staub R E, Baggett S, Chimmani R, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One; 2012 Jan 17. 7 (1):e30107.

• Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

  Aguer C, Gambarotta D, Mailloux R J, Moffat C, Dent R, McPherson R and Harper M E

  PLoS One; 2011 Dec 15. 6 (12):e28536.

• The effects of idebenone on mitochondrial bioenergetics

  Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G and Bernardi P

  Biochimica et Biophysica Acta (BBA) - Bioenergetics; 2011 Nov 4.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• SRT1720 improves survival and healthspan of obese mice

  Minor R K, Baur J A, Gomes A P, Ward T M, Csiszar A, Mercken E M, Abdelmohsen K, Shin Y-K, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta P M, Martin-Montalvo A, Hubbard B P, Zhang Y, Lehrmann E, White A A, Price N L, Swindell W R, Pearson K J, Becker K G, Bohr V A, Gorospe M, Egan J M, Talan M I, Auwerx J, Westphal C H, Ellis J L, Ungvari Z, Vlasuk G P, Elliott P J, Sinclair D A and de Cabo R

  Sci. Rep.; 2011 Aug 18. 1 (2011)

• Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

  Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A and Szabo C

  Proc Natl Acad Sci U S A; 2011 Aug 16. 108 (33):13829-13834.

• Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

  Hahm E R, Moura M B, Kelley E E, Van Houten B, Shiva S and Singh S V

  PLoS One; 2011 Aug 10. 6 (8):e23354.

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Chan D A, Sutphin P D, Nguyen P, Turcotte S, Lai E W, Banh A, Reynolds G E, Chi J T, Wu J, Solow-Cordero D E, Bonnet M, Flanagan J U, Bouley D M, Graves E E, Denny W A, Hay M P and Giaccia A J

  Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.

• 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

  Yao J, Chen S, Mao Z, Cadenas E and Brinton R D

  PLoS One; 2011 Jul 1. 6 (7):e21788.

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

  Yamasaki T, Tran T A, Oz O K, Raj G V, Schwarz R E, Deberardinis R J, Zhang X and Brugarolas J

  Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.

• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

  Chen H K, Ji Z S, Dodson S E, Miranda R D, Rosenblum C I, Reynolds I J, Freedman S B, Weisgraber K H, Huang Y and Mahley R W

  J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

  Oliva C R, Nozell S E, Diers A, McClugage S G, 3rd, Sarkaria J N, Markert J M, Darley-Usmar V M, Bailey S M, Gillespie G Y, Landar A and Griguer C E

  J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.

• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

  Irwin R W, Yao J, Ahmed S S, Hamilton R T, Cadenas E and Brinton R D

  Endocrinology; 2010 Dec 15. 152 (2):556-567.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Technology

Sort by: Title | Author | Date

• Enhanced tissue production through redox control in stem cell-laden hydrogels

  Reid B, Afzal J, McCartney A, Abraham R, O'Rourke B and Elisseeff J

  Tissue Eng Part A. 2013 Apr 30; [Epub ahead of print].

• Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

  Divakaruni A S, Wiley S E, Rogers G W, Andreyev A Y, Petrosyan S, Loviscach M, Wall E A, Yadava N, Heuck A P, Ferrick D A, Henry R R, McDonald W G, Colca J R, Simon M I, Ciaraldi T P and Murphy A N

  Proc Natl Acad Sci U S A; 2013 Apr 2. 110 (14):5422-7.

• Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood

  Chacko B K, Kramer P A, Ravi S, Johnson M S, Hardy R W, Ballinger S W and Darley-Usmar V M

  Lab Invest. 2013 Mar 25; [Epub ahead of print].

• Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice

  Jackson K C, Wohlers L M, Lovering R M, Schuh R A, Maher A C, Bonen A, Koves T R, Ilkayeva O, Thomson D M, Muoio D M and Spangenburg E E

  Am J Physiol Regul Integr Comp Physiol; 2013 Feb 1.

• Cellular Bioenergetics is an Important Determinant of the Molecular Imaging Signal Derived from Luciferase and the Sodium-Iodide Symporter

  Chang C, Chan A, Lin X, Higuchi T, Terrovitis J, Afzal J M, Rittenbach A, Sun D, Vakrou S, Woldemichael K, O'Rourke B, Wahl R, Pomper M, Tsui B and Abraham M R

  Circ Res; 2013 Feb 1. 112 (3):441-50.

• Glycolysis-respiration relationships in a neuroblastoma cell line

  Swerdlow R H, Lezi E, Aires D and Lu J

  Biochim Biophys Acta; 2013 Jan 10. 1830 (4):2891-2898.

• An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates Behavioral Phenotypes

  Vogel H, Montag D, Kanzleiter T, Jonas W, Matzke D, Scherneck S, Chadt A, Tole J, Kluge R, Joost H G and Schurmann A

  PLoS One; 2013 Jan 4. 8 (1):e53025.

• Determination of Oxidoreductase Activity Using a High Throughput Microplate Respiratory Measurement

  Hommes G, Gasser C A, Ammann E M and Corvini P F

  Anal Chem; 2013 Jan 2. 85 (1):283-91.

• Inhibitors of bacterial tubulin target bacterial membranes in vivo

  Foss M H, Eun Y-J, Grove C I, Pauw D A, Sorto N A, Rensvold J W, Pagliarini D J, Shaw J T and Weibel D B

  MedChemComm; 2013 Jan 1. 4 (1):112-119.

• Standardized Bioenergetic Profiling of Adult Mouse Cardiomyocytes

  Readnower R D, Brainard R E, Hill B G and Jones S P

  Physiol Genomics; 2012 Dec 18. 44 (24):1208-13.

• Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse Extracellular Flux XF24 Analysis

  Lange M L, Zeng Y, Knight A, Windebank A and Trushina E

  Frontiers in Neurology; 2012 Dec 14. 3 (175)

• The impact of mitochondrial and thermal stress on the bioenergetics and reserve respiratory capacity of fish cell lines

  Beck B H and Fuller S A

  J Aquat Anim Health; 2012 Dec 1. 24 (4):244-250.

• Integration of cellular bioenergetics with mitochondrial quality control and autophagy

  Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M

  Biol Chem; 2012 Nov 1. 393 (12):1485-1512.

• Transferring isolated mitochondria into tissue culture cells

  Yang Y-W and Koob M D

  Nucleic Acids Research; 2012 Oct 1. 40 (19):e148.

• Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry

  Clerc P, Carey G B, Mehrabian Z, Wei M, Hwang H, Girnun G D, Chen H, Martin S S and Polster B M

  PLoS One; 2012 Aug 3. 7 (8):e42487.

• Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

  Zhang J, Nuebel E, Wisidagama D R, Setoguchi K, Hong J S, Van Horn C M, Imam S S, Vergnes L, Malone C S, Koehler C M and Teitell M A

  Nat Protoc; 2012 Jun 1. 7 (6):1068-1085.

• Measurement of mitochondrial respiration in trophoblast culture

  Maloyan A, Mele J, Muralimanohara B and Myatt L

  Placenta; 2012 May 1. 33 (5):456-8.

• Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

  Clerc P and Polster B M

  PLoS One; 2012 Apr 4. 7 (3):e34465.

• Measuring mitochondrial respiration in intact single muscle fibers

  Schuh R A, Jackson K C, Khairallah R J, Ward C W and Spangenburg E E

  Am J Physiol Regul Integr Comp Physiol; 2012 Mar 1. 302 (6):R712-9.

• Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

  Schuh R A, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H and Polster B M

  J Neurosci Res; 2011 Dec 1. 89 (12):1979-1988.

• Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B G, Zhang J, Landar A and Darley-Usmar V M

  Free Radic Biol Med; 2011 Nov 1. 51 (9):1621-1635.

• High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

  Rogers G, Brand M D, Petrosyan S, Ashok D, Elorza A, Ferrick D and Murphy A N

  PLoS One; 2011 Jul 25. 6 (7):e21746.

• Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells

  Xu Q, Vu H, Liu L, Wang T C and Schaefer W H

  J Biomol NMR; 2011 Apr 1. 49 (4-Mar):207-219.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

• Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system

  Sauerbeck A, Pandya J, Singh I, Bittman K, Readnower R, Bing G and Sullivan P

  Journal of Neuroscience Methods; 2011 Mar 15. 198 (1):36-43.

• Assays Based on Integrated Cell System Properties

  Wu G

  Assay Development: Fundamentals and Practices. 2010 Jun 16; [Epub ahead of print].

• A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen consumption rate at various conditions

  Park J, Pak Y K and Pak J J

  Sensors and Actuators B: Chemical; 2010 May 18. 147 (1):263-269.

• Quantitative microplate-based respirometry with correction for oxygen diffusion

  Gerencser A A, Neilson A, Choi S W, Edman U, Yadava N, Oh R J, Ferrick D A, Nicholls D G and Brand M D

  Anal Chem; 2009 Aug 15. 81 (16):6868-6878.

• Advances in measuring cellular bioenergetics using extracellular flux

  Ferrick D A, Neilson A and Beeson C

  Drug Discov Today; 2008 Mar 1. 13 (40669):268-274.

• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292 (1):C125-136.

Review Articles

Sort by: Title | Author | Date

• The role of CSA and CSB protein in the oxidative stress response

  D'Errico M, Pascucci B, Lorio E, Van Houten B and Dogliotti E

  Mech Ageing Dev. 2013 Apr 3; [Epub ahead of print].

• Methods for assessing mitochondrial function in diabetes

  Perry C G, Kane D A, Lanza I R and Neufer P D

  Diabetes; 2013 Apr 1. 62 (4):1041-1053.

• The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells

  Hockenbery D, Tom M, Abikoff C and Margineantu D

  Cell Death Signaling in Cancer Biology and Treatment; 2013 Jan 1. 1 (2):35-51.

• Integration of cellular bioenergetics with mitochondrial quality control and autophagy

  Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M

  Biol Chem; 2012 Nov 1. 393 (12):1485-1512.

• Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging

  Horan M P, Pichaud N and Ballard J W

  J Gerontol A Biol Sci Med Sci; 2012 Oct 1. 67 (10):1022-35.

• The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

  Thomas C E and Will Y

  Expert Opinion on Drug Discovery; 2012 Feb 1. 7 (2):109-122.

• Mitochondria: isolation, structure and function

  Picard M, Taivassalo T, Gouspillou G and Hepple R T

  J Physiol; 2011 Sep 15. 589 (Pt 18):4413-4421.

• Uncoupling proteins and the control of mitochondrial reactive oxygen species production

  Mailloux R J and Harper M E

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

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