Publications with Seahorse XF Data

Publications, in which Seahorse data is included, are available within the research areas listed below. Clicking on a link will open a new browser window to PubMed.gov, the U.S. National Library of Medicine at the National Institutes of Health (NIH).

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• Identification of the molecular basis of doxorubicin-induced cardiotoxicity

  Zhang S, Liu X, Bawa-Khalfe T, Lu L S, Lyu Y L, Liu L F and Yeh E T

  Nature medicine; 2013 Nov 1. 18(11):1639-1642.

• p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

  Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsasser H P and Stiewe T

  Cell reports. 2013 May 8; [Epub ahead of print].

• WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

  Esen E, Chen J, Karner C M, Okunade A L, Patterson B W and Long F

  Cell metabolism; 2013 May 7. 14(5):745-55.

• Arsenic exposure induces the Warburg effect in cultured human cells

  Zhao F, Severson P, Pacheco S, Futscher B W and Klimecki W T

  Toxicol Appl Pharmacol. 2013 May 4; [Epub ahead of print].

• Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

  Lopez-Erauskin J, Galino J, Ruiz M, Cuezva J M, Fabregat I, Cacabelos D, Boada J, Martinez J, Ferrer I, Pamplona R, Villarroya F, Portero-Otin M, Fourcade S and Pujol A

  Human molecular genetics; 2013 May 3.

• Lacritin rescues stressed epithelia via rapid FOXO3 associated autophagy that restores metabolism

  Wang N, Zimmerman K, Raab R W, McKown R L, Hutnik C M, Talla V, Tyler M F, Lee J K and Laurie G W

  J Biol Chem. 2013 May 2; [Epub ahead of print].

• A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

  McQuaker S J, Quinlan C L, Caldwell S T, Brand M D and Hartley R C

  Chembiochem. 2013 May 2; [Epub ahead of print].

• Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

  Kidani Y, Elsaesser H, Hock M B, Vergnes L, Williams K J, Argus J P, Marbois B N, Komisopoulou E, Wilson E B, Osborne T F, Graeber T G, Reue K, Brooks D G and Bensinger S J

  Nature immunology; 2013 May 1. 14(5):489-499.

• MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein

  Han K S and Ayer D E

  Biochem J. 2013 May 1; [Epub ahead of print].

• Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

  Cypess A M, White A P, Vernochet C, Schulz T J, Xue R, Sass C A, Huang T L, Roberts-Toler C, Weiner L S, Sze C, Chacko A T, Deschamps L N, Herder L M, Truchan N, Glasgow A L, Holman A R, Gavrila A, Hasselgren P O, Mori M A, Molla M and Tseng Y H

  Nat Med; 2013 May 1. 19(5):635-639.

• Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

  Strickertsson J A, Desler C, Martin-Bertelsen T, Machado A M, Wadstrom T, Winther O, Rasmussen L J and Friis-Hansen L

  PloS one; 2013 Apr 30. 8(4):e63147.

• Enhanced tissue production through redox control in stem cell-laden hydrogels

  Reid B, Afzal J, McCartney A, Abraham R, O'Rourke B and Elisseeff J

  Tissue Eng Part A. 2013 Apr 30; [Epub ahead of print].

• Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKK[beta]

  Iseli T J, Turner N, Zeng X-Y, Cooney G J, Kraegen E W, Yao S, Ye Y, James D E and Ye J-M

  PloS one; 2013 Apr 25. 8(4):e62309.

• The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

  Henao-Mejia J, Williams A, Goff L A, Staron M, Licona-Limon P, Kaech S M, Nakayama M, Rinn J L and Flavell R A

  Immunity. 2013 Apr 24; [Epub ahead of print].

• TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

  Settembre C, De Cegli R, Mansueto G, Saha P K, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jurgen Klisch T, Wollenberg A C, Di Bernardo D, Chan L, Irazoqui J E and Ballabio A

  Nature cell biology. 2013 Apr 21; [Epub ahead of print].

• Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells

  Im A R, Kim Y H, Uddin M R, Chae S, Lee H W, Kim Y S and Lee M Y

  Cell Mol Neurobiol. 2013 Apr 20; [Epub ahead of print].

• Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

  Kalantari-Dehaghi M, Chen Y, Deng W, Chernyavsky A, Marchenko S, Wang P H and Grando S A

  J Biol Chem. 2013 Apr 18; [Epub ahead of print].

• The role of p38 in mitochondrial respiration in male and female mice

  Ju X, Wen Y, Metzger D and Jung M

  Neurosci Lett. 2013 Apr 17; [Epub ahead of print].

• The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

  Anedda A, Lopez-Bernardo E, Acosta-Iborra B, Saadeh Suleiman M, Landazuri M O and Cadenas S

  Free Radic Biol Med. 2013 Apr 16; [Epub ahead of print].

• Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress

  Sun Q, Gao W, Loughran P, Shapiro R, Fan J, Billiar T R and Scott M J

  J Biol Chem. 2013 Apr 15; [Epub ahead of print].

• Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

  Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee M J, Lee S, Vartholomaiou E, Tatokoro M, Beebe K, Miyajima N, Mohney R P, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K, Trepel J, Picard D and Neckers L

  Proc Natl Acad Sci U S A. 2013 Apr 5; [Epub ahead of print].

• Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis

  Segear Johnson E, Lindblom K R, Robeson A, Stevens R D, Ilkayeva O R, Newgard C B, Kornbluth S and Andersen J L

  J Biol Chem.. 2013 Apr 3; [Epub ahead of print].

• The role of CSA and CSB protein in the oxidative stress response

  D'Errico M, Pascucci B, Lorio E, Van Houten B and Dogliotti E

  Mech Ageing Dev. 2013 Apr 3; [Epub ahead of print].

• Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

  Jeso V, Yang C, Cameron M D, Cleveland J L and Micalizio G C

  ACS Chem Biol. 2013 Apr 2; [Epub ahead of print].

• Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

  Divakaruni A S, Wiley S E, Rogers G W, Andreyev A Y, Petrosyan S, Loviscach M, Wall E A, Yadava N, Heuck A P, Ferrick D A, Henry R R, McDonald W G, Colca J R, Simon M I, Ciaraldi T P and Murphy A N

  Proc Natl Acad Sci U S A; 2013 Apr 2. 110(14):5422-7.

• Mitochondria-Targeted Nitroxide, Mito-CP, Suppresses Medullary Thyroid Carcinoma Cell Survival in Vitro and in Vivo

  Starenki D and Park J I

  J Clin Endocrinol Metab; 2013 Apr 1. 98(4):1529-40.

• Global analysis of SUMO chain function reveals multiple roles in chromatin regulation

  Srikumar T, Lewicki M C, Costanzo M, Tkach J M, van Bakel H, Tsui K, Johnson E S, Brown G W, Andrews B J, Boone C, Giaever G, Nislow C and Raught B

  J Cell Biol; 2013 Apr 1. 201(1):145-163.

• Ablation of Dihydroceramide Desaturase-1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

  Siddique M M, Ying L, Wang L, Jianhong C, Mal M, Ilkayeva O, Wu Y J, Bay B H and Summers S A

  Mol Cell Biol. 2013 Apr 1; [Epub ahead of print].

• Methods for assessing mitochondrial function in diabetes

  Perry C G, Kane D A, Lanza I R and Neufer P D

  Diabetes; 2013 Apr 1. 62(4):1041-1053.

• Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury

  Masuzawa A, Black K M, Pacak C A, Ericsson M, Barnett R J, Drumm C, Seth P, Bloch D B, Levitsky S, Cowan D B and McCully J D

  Am J Physiol Heart Circ Physiol.; 2013 Apr 1. 304(7):H966-982.

• Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

  Hall A, Meyle K D, Lange M K, Klima M, Sanderhoff M, Dahl C, Abildgaard C, Thorup K, Moghimi S M, Jensen P B, Bartek J, Guldberg P and Christensen C

  Oncotarget; 2013 Apr 1. 4(4):584-599.

• Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

  Bachar-Wikstrom E, Wikstrom J D, Ariav Y, Tirosh B, Kaiser N, Cerasi E and Leibowitz G

  Diabetes; 2013 Apr 1. 62(4):1227-1237.

• Involvement of estrogen receptor beta5 in the progression of glioma

  Li W, Winters A, Poteet E, Ryou M G, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa K J, Simpkins J W and Yang S H

  Brain Res; 2013 Mar 29. 1503:97-107.

• Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

  Sanchez W Y, McGee S L, Connor T, Mottram B, Wilkinson A, Whitehead J P, Vuckovic S and Catley L

  Br J Cancer. 2013 Mar 26; [Epub ahead of print].

• Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

  Modis K, Asimakopoulou A, Coletta C, Papapetropoulos A and Szabo C

  Biochem Biophys Res Commun. 2013 Mar 26; [Epub ahead of print].

• Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood

  Chacko B K, Kramer P A, Ravi S, Johnson M S, Hardy R W, Ballinger S W and Darley-Usmar V M

  Lab Invest. 2013 Mar 25; [Epub ahead of print].

• Characterization of transgenic Gfrp knock-in mice: Implications for tetrahydrobiopterin in modulation of normal tissue radiation responses

  Pathak R, Pawar S, Fu Q, Gupta P K, Berbee M, Garg S, Sridharn V, Wang W, Prabath B, Krager K, Boerma M, Ghosh S, Cheema A, Hendrickson H, Aykin-Burns N and Hauer-Jensen M

  Antioxid Redox Signal. 2013 Mar 23; [Epub ahead of print].

• Glutaredoxin-2 Is Required to Control Proton Leak through Uncoupling Protein-3

  Mailloux R J, Xuan J Y, Beauchamp B, Jui L, Lou M and Harper M E

  J Biol Chem; 2013 Mar 22. 288(12):8365-8379.

• Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

  Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agro A, Melino G and Willis A

  Cell Death Dis; 2013 Mar 21. 4:e549.

• Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation

  Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron A C, Kopp J, Yamamoto M and Noguchi C T

  Int J Biochem Cell Biol; 2013 Mar 20.

• Metabolic Changes During Ovarian Cancer Progression as Targets for Sphingosine Treatment

  Anderson A S, Roberts P C, Frisard M I, McMillan R P, Brown T J, Lawless M H, Hulver M W and Schmelz E M

  Exp Cell Res; 2013 Mar 19.

• Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

  Voloboueva L A, Emery J F, Sun X and Giffard R G

  FEBS Lett; 2013 Mar 18. 587(6):756-62.

• Rab27B-Mediated Metabolic Reprogramming Induces Secretome Acidification and Chemoresistance in Breast Cancer Cells

  Hendrix A, Ciccone C, Gespach C, Bracke M, Wever O D and Westbroek W

  Exosomes and Microvesicles; 2013 Mar 18.

• Oncogenic BRAF Regulates Oxidative Metabolism via PGC1alpha and MITF

  Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe G C, Frederick D T, Hurley A D, Nellore A, Kung A L, Wargo J A, Song J S, Fisher D E, Arany Z and Widlund H R

  Cancer Cell; 2013 Mar 18. 23(3):302-315.

• Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

  Shen Y-A, Hung P-H, Chi W-H, Wang C-Y, Hsieh Y-T, Wei Y H and Chen Y-J

  Evidence-Based Complementary and Alternative Medicine. 2013 Mar 16; [Epub ahead of print].

• Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma

  Kirstein M M, Boukouris A E, Pothiraju D, Buitrago-Molina L E, Marhenke S, Lamlé J, Orlik J, Kühnel F, Hegermann J, Manns M P and Vogel A

  Liver International. 2013 Mar 15; [Epub ahead of print].

• Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

  Ryu M J, Kim S J, Kim Y K, Choi M J, Tadi S, Lee M H, Lee S E, Chung H K, Jung S B, Kim H J, Jo Y S, Kim K S, Lee S H, Kim J M, Kweon G R, Park K C, Lee J U, Kong Y Y, Lee C H, Chung J and Shong M

  PLoS Genet; 2013 Mar 14. 9(3):e1003356.

• Opa1 is required for proper mitochondrial metabolism in early development

  Rahn J J, Stackley K D and Chan S S

  PLoS One; 2013 Mar 14. 8(3):e59218.

• Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase

  Quan H Y, Kim S J, Kim D Y, Jo H K, Kim G W and Chung S H

  Fitoterapia. 2013 Mar 14; [Epub ahead of print].

• Mitochondrial matrix P53 sensitizes cells to oxidative stress

  Koczor C A, Torres R A, Fields E J, Boyd A and Lewis W

  Mitochondrion; 2013 Mar 14. 13(14):277-281.

• MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

  Grosso S, Doyen J, Parks S K, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noel A, Pouyssegur J, Barbry P, Mazure N M and Mari B

  Cell Death Dis; 2013 Mar 14. 4(e544):2013.

• Amphiphilic silver-delaminated clay nanohybrids and their composites with polyurethane: physico-chemical and biological evaluations

  Chi T-Y, Yeh H-Y, Lin J-J, Jeng U S and Hsu S-h

  J Mater Chem B; 2013 Mar 11. 1(16):2178-2189.

• Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 beta-cells accompany functional adaptations to lipotoxicity

  Malmgren S, Spegel P, Danielsson A P, Nagorny C L, Andersson L E, Dekker Nitert M, Ridderstrale M, Mulder H and Ling C

  J Biol Chem. 2013 Mar 8; [Epub ahead of print].

• Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells

  Jhas B, Sriskanthadevan S, Skrtic M, Sukhai M A, Voisin V, Jitkova Y, Gronda M, Hurren R, Laister R C, Bader G D, Minden M D and Schimmer A D

  PLoS One; 2013 Mar 8. 8(3):e58367.

• alpha-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKalpha in vitro

  Wang L and Brautigan D L

  Nat Commun; 2013 Mar 7. 4(1559)

• Rosemary (Rosmarinus officinalis L.) extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells

  Tu Z, Moss-Pierce T, Ford P and Jiang A

  J Agric Food Chem. 2013 Mar 6; [Epub ahead of print].

• Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARgamma Specifies Lipid Storage versus Thermogenic Gene Programs

  Villanueva C J, Vergnes L, Wang J, Drew B G, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener A L, Reue K, Fong L G, Young S G and Tontonoz P

  Cell Metab; 2013 Mar 5. 17(3):423-435.

• Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

  Parks S K, Mazure N M, Counillon L and Pouyssegur J

  J Cell Physiol. 2013 Mar 4; [Epub ahead of print].

• Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1

  Rafikov R, Rafikova O, Aggarwal S, Gross C, Sun X, Desai J, Fulton D and Black S M

  J Biol Chem; 2013 Mar 1. 288(9):6212-6226.

• Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

  Lee S H, Jouihan H A, Cooksey R C, Jones D, Kim H J, Winge D R and McClain D A

  Endocrinology; 2013 Mar 1. 154(3):1029-1038.

• Role of dynamin-related protein 1 (drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus

  Hong Z, Kutty S, Toth P T, Marsboom G, Hammel J M, Chamberlain C, Ryan J J, Zhang H J, Sharp W W, Morrow E, Trivedi K, Weir E K and Archer S L

  Circ Res; 2013 Mar 1. 112(5):802-815.

• Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction

  Gero D, Szoleczky P, Suzuki K, Modis K, Olah G, Coletta C and Szabo C

  Diabetes; 2013 Mar 1. 62(3):953-964.

• The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism

  Chu K, Boley K M, Moraes R, Barsky S H and Robertson F M

  Oncotarget; 2013 Mar 1. 4(3):446-462.

• The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

  Chowdhury S K, Smith D R and Fernyhough P

  Neurobiol Dis; 2013 Mar 1.

• Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death

  Palorini R, Simonetto T, Cirulli C and Chiaradonna F

  International Journal of Cell Biology. 2013 Feb 28; [Epub ahead of print].

• Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria

  Suchorolski M T, Paulson T G, Sanchez C A, Hockenbery D and Reid B J

  PLoS One; 2013 Feb 27. 8(2):e56884.

• The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the Numb-p53 Complex

  Feldman D E, Chen C, Punj V and Machida K

  PLoS One; 2013 Feb 27. 8(2):e57312.

• Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

  Dong C, Yuan T, Wu Y, Wang Y, Fan T W, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung M C, Evers B M and Zhou B P

  Cancer Cell. 2013 Feb 27; [Epub ahead of print].

• An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

  Williams K J, Argus J P, Zhu Y, Wilks M Q, Marbois B N, York A G, Kidani Y, Pourzia A L, Akhavan D, Lisiero D N, Komisopoulou E, Henkin A H, Soto H, Chamberlain B T, Vergnes L, Jung M E, Torres J Z, Liau L M, Christofk H R, Prins R M, Mischel P S, Reue K, Graeber T G and Bensinger S

  Cancer Res; 2013 Feb 25.

• Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3

  Li L, Zhang J, Yang Y, Wang Q, Gao L, Chang T, Zhang X, Xiang G, Cao Y, Shi Z, Zhao M and Gao G

  Nanoscale Res Lett; 2013 Feb 22. 8(1):100.

• Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

  Sena L A, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman D A, Wang C R, Schumacker P T, Licht J D, Perlman H, Bryce P J and Chandel N S

  Immunity; 2013 Feb 21. 38(2):225-236.

• Potentiation of brain mitochondrial function by S-equol and R/S-equol Estrogen Receptor beta selective phytoSERM treatments

  Yao J, Zhao L, Mao Z, Chen S, Wong K, To J and Brinton R D

  Brain Res. 2013 Feb 18; [Epub ahead of print].

• Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells

  Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q and Zhu D

  Cell Death Dis; 2013 Feb 14. 4(e494):2013.

• Reversing the Warburg Effect as a Treatment for Glioblastoma

  Poteet E, Choudhury G R, Winters A, Li W, Ryou M G, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir S T, Yan H, Bigner D D, Simpkins J W and Yang S H

  J Biol Chem. 2013 Feb 13; [Epub ahead of print].

• Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity

  Bruckbauer A and Zemel M B

  Diabetes Metab Syndr Obes; 2013 Feb 13. 6(93-102):2013.

• PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

  Vazquez F, Lim J H, Chim H, Bhalla K, Girnun G, Pierce K, Clish C B, Granter S R, Widlund H R, Spiegelman B M and Puigserver P

  Cancer Cell. 2013 Feb 12; [Epub ahead of print].

• LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

  Shackelford D B, Abt E, Gerken L, Vasquez D S, Seki A, Leblanc M, Wei L, Fishbein M C, Czernin J, Mischel P S and Shaw R J

  Cancer Cell; 2013 Feb 11. 23(2):143-58.

• An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice

  Reilly S M, Chiang S H, Decker S J, Chang L, Uhm M, Larsen M J, Rubin J R, Mowers J, White N M, Hochberg I, Downes M, Yu R T, Liddle C, Evans R M, Oh D, Li P, Olefsky J M and Saltiel A R

  Nat Med. 2013 Feb 10; [Epub ahead of print].

• Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion

  Cherry A B, Gagne K E, McLoughlin E M, Baccei A, Gorman B, Hartung O, Miller J D, Zhang J, Zon R L, Ince T A, Neufeld E J, Lerou P H, Fleming M D, Daley G Q and Agarwal S

  Stem Cells. 2013 Feb 8; [Epub ahead of print].

• Metabolism of 1-Methyl-4-phenyl-1-2-3-6-tetrahydropyridine by Mitochondria-targeted Cytochrome P450 2D6: Implications in Parkinson's Disease

  Bajpai P, Sangar M C, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang J K, Martin M V, Guengerich F P and Avadhani N G

  J Biol Chem; 2013 Feb 8. 288(6):4436-51.

• Tracking metastasis and tricking cancer

  Marx V

  Nature; 2013 Feb 7. 494(7435):133-136.

• Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

  Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan N G, Forcales S, Puri P L, Leone T C, Marine J E, Calkins H, Kelly D P, Judge D P and Chen H S

  Nature; 2013 Feb 7. 494(7435):105-110.

• The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

  Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P

  Oncogene; 2013 Feb 7. 32(6):699-712.

• Knockdown of RyR3 Enhances Adiponectin Expression Through an atf3-Dependent Pathway

  Tsai S H, Chang E Y, Chang Y C, Hee S W, Tsai Y C, Chang T J and Chuang L M

  Endocrinology. 2013 Feb 6; [Epub ahead of print].

• Metabolic changes in cancer cells upon suppression of MYC

  Anso E, Mullen A, Felsher D, Mates J, DeBerardinis R and Chandel N

  Cancer Metab; 2013 Feb 4. 1(1):7.

• Ciliary neurotrophic factor activates NF-kappaB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

  Saleh A, Roy Chowdhury S K, Smith D R, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi K E, Calcutt N A and Fernyhough P

  Neuropharmacology; 2013 Feb 1. 2013 Feb(65):65-73.

• Role of p90RSK in regulating the Crabtree effect: implications for cancer

  Redman E K, Brookes P S and Karcz M K

  Biochem Soc Trans; 2013 Feb 1. 41(1):124-126.

• Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death

  Perron N R, Beeson C and Rohrer B

  J Bioenerg Biomembr; 2013 Feb 1. 45(1-2):101-9.

• Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet beta-Cells

  Nishiki Y, Adewola A, Hatanaka M, Templin A T, Maier B and Mirmira R G

  Mol Endocrinol; 2013 Feb 1. 27(2):336-349.

• Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

  Modis K, Coletta C, Erdelyi K, Papapetropoulos A and Szabo C

  FASEB J; 2013 Feb 1. 27(2):601-611.

• Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

  Liew C W, Boucher J, Cheong J K, Vernochet C, Koh H J, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng Y H, Hellerstein M K, Farmer S R, Goodyear L, Doria A, Bluher M, Hsu S I and Kulkarni R N

  Nat Med; 2013 Feb 1. 19(2):217-26.

• Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

  Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot M L, Ruderman N B, Nolan C J, Joly E, Madiraju S R, Poitout V and Prentki M

  Diabetes. 2013 Feb 1; [Epub ahead of print].

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• Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice

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• Cellular Bioenergetics is an Important Determinant of the Molecular Imaging Signal Derived from Luciferase and the Sodium-Iodide Symporter

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• Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

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• Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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• Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+-activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3

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• Central Glucagon-Like Peptide 1 Receptor (Glp1r)-Induced Anorexia Requires Glucose Metabolism-Mediated Suppression of AMPK and is Impaired by Central Fructose

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• Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

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• Protein O-GlcNAcylation is a Novel Cytoprotective Signal in Cardiac Stem Cells

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• Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal

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• BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

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• The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

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• Parkin Deficiency Exacerbates Cardiac Injury and Reduces Survival Following Myocardial Infarction

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• Blocking c-jun-N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-hydroxydopamine-induced Toxicity in vitro and in vivo

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• AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

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• An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates Behavioral Phenotypes

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• Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation

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• Regulation of glycolysis by pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

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• Acidity generated by the tumor microenvironment drives local invasion

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• Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null mice

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• Effect of Cholinergic Signaling on Neuronal Cell Bioenergetics

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• Myocardial accumulation of bupivacaine and ropivacaine is associated with reversible effects on mitochondria and reduced myocardial function

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• Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings

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• Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

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• LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

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• Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF

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• Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer

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• Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

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• Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse Extracellular Flux XF24 Analysis

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• Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3alpha/beta and Bax, leading to permeability transition pore opening and tumor cell death

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• Alteration of Fatty-Acid-Metabolizing Enzymes Affects Mitochondrial Form and Function in Hereditary Spastic Paraplegia

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• Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

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• Mouse mtDNA mutant model of Leber hereditary optic neuropathy

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• GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

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• Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

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• Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

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• Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

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• No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease

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• Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

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• Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/ref-1) is an indicator of energy disruption in neurons

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• Characterization of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

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• Stomatin-like Protein 2 Deficiency in T Cells Is Associated with Altered Mitochondrial Respiration and Defective CD4+ T Cell Responses

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• Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro

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• MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake that Regulates Cell Survival

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• OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

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• Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

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• Methylene blue as a cerebral metabolic and hemodynamic enhancer

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• Importance of glycolysis and oxidative phosphorylation in advanced melanoma

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• TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

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• Mitochondrial DNA damage Is associated with reduced mitochondrial bioenergetics in Huntington's disease

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• Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

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• MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

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• The Methyl Xanthine Caffeine Inhibits DNA Damage Signaling and Reactive Species and Reduces Atherosclerosis in ApoE-/- Mice

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• Role of TRIB3 in Regulation of Insulin Sensitivity and Nutrient Metabolism during Short-term Fasting and Nutrient Excess

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• An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression

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• Fatty Acid Oxidation Is Essential for Egg Production by the Parasitic Flatworm Schistosoma mansoni

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• Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial beta-oxidation

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• Pyruvate Uptake Is Increased in Highly Invasive Ovarian Cancer Cells under Anoikis Conditions for Anaplerosis, Mitochondrial Function, and Migration

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• Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

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• Protein carbonylation and adipocyte mitochondrial function

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• GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence

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• MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

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• Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

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• Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

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• Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

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• Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

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• Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

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• CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

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• Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Ppargamma

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• Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry

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• Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

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• Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi

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• LRH-1-dependent glucose sensing determines intermediary metabolism in liver

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• Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

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• ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

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• Expression Profiling of Attenuated Mitochondrial Function Identifies Retrograde Signals in Drosophila

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• Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

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• PGC-1beta mediates adaptive chemoresistance associated with mitochondrial DNA mutations

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• Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

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• Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

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• Acyl-CoA thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

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• A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer

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• beta2 Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis

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• Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms

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• Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

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• Adjustments of Mitochondrial Energy Transduction in Response to Physiological and Environmental Challenge

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• Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

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• Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

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• An NQO1 substrate with potent anti-tumor activity that selectively kills by PARP1-induced programmed necrosis

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• Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

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• Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats

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• Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan

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• Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

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• The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

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• Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

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• Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

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• An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

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• Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

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• Cellular Responses to the Metal-Binding Properties of Metformin

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• Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

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• Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme

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• Inhibiting Systemic Autophagy during Interleukin 2 (IL-2) Immunotherapy Promotes Long-term Tumor Regression

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• p53 and Mitochondrial DNA: Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals

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• Peroxisome Proliferator-Activated Receptor gamma Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

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• Disruption of fnip1 reveals a metabolic checkpoint controlling B lymphocyte development

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• Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension

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• Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

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• Additive Effects of Mitochondrion-targeted Cytochrome CYP2E1 and Alcohol Toxicity on Cytochrome c Oxidase Function and Stability of Respirosome Complexes

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• Mitochondria Distinguish Granule-Stored from de novo Synthesized Tumor Necrosis Factor Secretion in Human Mast Cells

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• Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function

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• Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts

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• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

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• Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing

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• Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

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• A Cell-Based Phenotypic Assay to Identify Cardioprotective Agents

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• Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

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• The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

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• A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

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• Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency

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• Correcting human mitochondrial mutations with targeted RNA import

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• FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

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• HIFalpha induced switch from bivalent to exclusively glycolytic metabolism during ESC--EpiSC transition

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• Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

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• GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling

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• Lung 18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

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• Pten positively regulates brown adipose function, energy expenditure, and longevity

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• DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

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• Ethanol Suppresses Ureagenesis in Rat Hepatocytes: Role of Acetaldehyde

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• Measuring mitochondrial respiration in intact single muscle fibers

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• Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

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• Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

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• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

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• Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

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• Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

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• Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts

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• Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation

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• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

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• Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

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• Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

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• Dysregulation of Ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

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• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

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• Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

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• Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

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• Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

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• SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

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• Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

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• Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1

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• Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development

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• Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol

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• Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

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• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

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• The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

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• Pancreatic cancers require autophagy for tumor growth

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• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

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• Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

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• Development of chromanes as novel inhibitors of the uncoupling proteins

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• Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

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• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

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• The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

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• The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

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• Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

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• ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

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• Meclizine is neuroprotective in models of Huntington's disease

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• Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction

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• Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

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• A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

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• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

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• On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate

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• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

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• KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

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• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

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• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

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• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

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• Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

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• Mechanisms of metformin action on glucose transport and metabolism in human adipocytes

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• Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

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• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

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• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

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• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

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• MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

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• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy

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• Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis

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• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

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• Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

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• Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype

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• Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity

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• Respiration in adipocytes is inhibited by reactive oxygen species

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• A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

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• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria

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• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

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• Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

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• Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

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• Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

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• Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

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• Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

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• A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen consumption rate at various conditions

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• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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  Proc Natl Acad Sci U S A; 2010 May 11. 107(19):8788-8793.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11(5):412-426.

• Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts

  Moran M, Rivera H, Sanchez-Arago M, Blazquez A, Merinero B, Ugalde C, Arenas J, Cuezva J M and Martin M A

  Biochim Biophys Acta; 2010 May 1. 1802(5):443-453.

• Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration

  Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P and Nicotera P

  Hum Mol Genet; 2010 May 1. 19(9):1669-1677.

• Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

  Bao J, Lu Z, Joseph J J, Carabenciov D, Dimond C C, Pang L, Samsel L, McCoy J P, Jr., Leclerc J, Nguyen P, Gius D and Sack M N

  J Cell Biochem; 2010 May 1. 110(1):238-247.

• Mitochondrial and nuclear genomic responses to loss of LRPPRC expression

  Gohil V M, Nilsson R, Belcher-Timme C A, Luo B, Root D E and Mootha V K

  J Biol Chem; 2010 Apr 30. 285(18):13742-13747.

• Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

  Dranka B P, Hill B G and Darley-Usmar V M

  Free Radic Biol Med; 2010 Apr 1. 48(7):905-914.

• Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

  Chakrabarti P, English T, Shi J, Smas C M and Kandror K V

  Diabetes; 2010 Apr 1. 59(4):775-781.

• Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

  Blouin M J, Zhao Y, Zakikhani M, Algire C, Piura E and Pollak M

  Cancer Lett; 2010 Mar 28. 289(2):246-253.

• The homeobox protein Prox1 is a negative modulator of ERR{α}/PGC-1{α} bioenergetic functions

  Charest-Marcotte A, Dufour C R, Wilson B J, Tremblay A M, Eichner L J, Arlow D H, Mootha V K and Giguere V

  Genes Dev; 2010 Mar 15. 24(6):537-542.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11(3):213-219.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28(3):249-255.

• HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

  Capasso M, Bhamrah M K, Henley T, Boyd R S, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny V V, Morgan D, Gascoyne R D, Vigorito E, DeCoursey T E, MacLennan I C and Dyer M J

  Nat Immunol; 2010 Mar 1. 11(3):265-272.

• Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers

  Alakhova D Y, Rapoport N Y, Batrakova E V, Timoshin A A, Li S, Nicholls D, Alakhov V Y and Kabanov A V

  J Control Release; 2010 Feb 25. 142(1):89-100.

• Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation

  Hill B G, Higdon A N, Dranka B P and Darley-Usmar V M

  Biochim Biophys Acta; 2010 Feb 1. 1797(2):285-295.

• A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

  Shaham O, Slate N G, Goldberger O, Xu Q, Ramanathan A, Souza A L, Clish C B, Sims K B and Mootha V K

  Proc Natl Acad Sci U S A; 2010 Jan 26. 107(4):1571-1575.

• The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α

  Zhong L, D'Urso A, Toiber D, Sebastian C, Henry R E, Vadysirisack D D, Guimaraes A, Marinelli B, Wikstrom J D, Nir T, Clish C B, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai O S, Ellisen L W, Espinosa J M and Mostoslavsky R

  Cell; 2010 Jan 22. 140(2):280-293.

• UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

  Yang Y, Valera V A, Padilla-Nash H M, Sourbier C, Vocke C D, Vira M A, Abu-Asab M S, Bratslavsky G, Tsokos M, Merino M J, Pinto P A, Srinivasan R, Ried T, Neckers L and Linehan W M

  Cancer Genet Cytogenet; 2010 Jan 1. 196(1):45-55.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4(12):e8329.

• Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

  Swerdlow R H

  Pharmaceuticals; 2009 Dec 3. 2(3):150-167.

• Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77

  Chao L C, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva O R, Ding S Y, Reue K, Watt M J, Newgard C B, Pilch P F, Hevener A L and Tontonoz P

  Diabetes; 2009 Dec 1. 58(12):2788-2796.

• Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

  Cairns R A, Bennewith K L, Graves E E, Giaccia A J, Chang D T and Denko N C

  Clin Cancer Res; 2009 Dec 1. 15(23):7170-7174.

• Insulin signaling regulates mitochondrial function in pancreatic beta-cells

  Liu S, Okada T, Assmann A, Soto J, Liew C W, Bugger H, Shirihai O S, Abel E D and Kulkarni R N

  PLoS One; 2009 Nov 24. 4(11):e7983.

• Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

  Malmgren S, Nicholls D G, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H and Sharoyko V V

  J Biol Chem; 2009 Nov 20. 284(47):32395-32404.

• Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

  Hill B G, Dranka B P, Zou L, Chatham J C and Darley-Usmar V M

  Biochem J; 2009 Nov 15. 424(1):99-107.

• Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue

  Kang H W, Ribich S, Kim B W, Hagen S J, Bianco A C and Cohen D E

  J Lipid Res; 2009 Nov 1. 50(11):2212-2221.

• KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

  Costanzo-Garvey D L, Pfluger P T, Dougherty M K, Stock J L, Boehm M, Chaika O, Fernandez M R, Fisher K, Kortum R L, Hong E G, Jun J Y, Ko H J, Schreiner A, Volle D J, Treece T, Swift A L, Winer M, Chen D, Wu M, Leon L R, Shaw A S, McNeish J, Kim J K, Morrison D K, Tschop M H and Lewis R E

  Cell Metab; 2009 Nov 1. 10(5):366-378.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10(4):273-284.

• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

  Wu N, Yin L, Hanniman E A, Joshi S and Lazar M A

  Genes Dev; 2009 Sep 15. 23(18):2201-2209.

• C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

  Vernochet C, Peres S B, Davis K E, McDonald M E, Qiang L, Wang H, Scherer P E and Farmer S R

  Mol Cell Biol; 2009 Sep 1. 29(17):4714-4728.

• TGR5-mediated bile acid sensing controls glucose homeostasis

  Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J and Schoonjans K

  Cell Metab; 2009 Sep 1. 10(3):167-177.

• Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

  Yao J, Irwin R W, Zhao L, Nilsen J, Hamilton R T and Brinton R D

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106(34):14670-14675.

• Polo-like kinases mediate cell survival in mitochondrial dysfunction

  Matsumoto T, Wang P Y, Ma W, Sung H J, Matoba S and Hwang P M

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106(34):14542-14546.

• Quantitative microplate-based respirometry with correction for oxygen diffusion

  Gerencser A A, Neilson A, Choi S W, Edman U, Yadava N, Oh R J, Ferrick D A, Nicholls D G and Brand M D

  Anal Chem; 2009 Aug 15. 81(16):6868-6878.

• A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

  Baughman J M, Nilsson R, Gohil V M, Arlow D H, Gauhar Z and Mootha V K

  PLoS Genet; 2009 Aug 1. 5(8):e1000590.

• Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

  de Groof A J, te Lindert M M, van Dommelen M M, Wu M, Willemse M, Smift A L, Winer M, Oerlemans F, Pluk H, Fransen J A and Wieringa B

  Mol Cancer; 2009 Jul 31. 8(1):54.

• Bmi1 regulates mitochondrial function and the DNA damage response pathway

  Liu J, Cao L, Chen J, Song S, Lee I H, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L Y, Ahn B H, Kumar N G, Rovira, II, Xu X L, van Lohuizen M, Motoyama N, Deng C X and Finkel T

  Nature; 2009 May 21. 459(7245):387-392.

• Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

  Choi S W, Gerencser A A and Nicholls D G

  J Neurochem; 2009 May 1. 109(4):1179-1191.

• AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

  Canto C, Gerhart-Hines Z, Feige J N, Lagouge M, Noriega L, Milne J C, Elliott P J, Puigserver P and Auwerx J

  Nature; 2009 Apr 23. 458(7241):1056-1060.

• Methods in Cancer Metabolism: Real-Time Measurement of Mitochondrial Respiration and Glycolysis Rates of Cancer Cells in a Microplate

  Wu M

  Am. Assoc. Cancer Res. Education Book; 2009 Apr 1. :295-300.

• Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

  Wu J J, Quijano C, Chen E, Liu H, Cao L, Fergusson M M, Rovira, II, Gutkind S, Daniels M P, Komatsu M and Finkel T

  Aging (Albany NY); 2009 Apr 1. 1(4):425-437.

• LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

  Xie H, Valera V A, Merino M J, Amato A M, Signoretti S, Linehan W M, Sukhatme V P and Seth P

  Mol Cancer Ther; 2009 Mar 1. 8(3):626-635.

• Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

  Slomiany M G, Grass G D, Robertson A D, Yang X Y, Maria B L, Beeson C and Toole B P

  Cancer Res; 2009 Feb 15. 69(4):1293-1301.

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

  Dykens J A, Jamieson J, Marroquin L, Nadanaciva S, Billis P A and Will Y

  Toxicol Appl Pharmacol; 2008 Dec 1. 233(2):203-210.

• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

  Feige J N, Lagouge M, Canto C, Strehle A, Houten S M, Milne J C, Lambert P D, Mataki C, Elliott P J and Auwerx J

  Cell Metab; 2008 Nov 1. 8(5):347-358.

• O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration

  Sridharan V, Guichard J, Li C Y, Muise-Helmericks R, Beeson C C and Wright G L

  Am J Physiol Cell Physiol; 2008 Jul 1. 295(1):C29-37.

• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

  Dykens J A, Jamieson J D, Marroquin L D, Nadanaciva S, Xu J J, Dunn M C, Smith A R and Will Y

  Toxicol Sci; 2008 Jun 1. 103(2):335-345.

• Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

  Amo T, Yadava N, Oh R, Nicholls D G and Brand M D

  Gene; 2008 Mar 31. 411(40545):69-76.

• Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

  Simonides W S, Mulcahey M A, Redout E M, Muller A, Zuidwijk M J, Visser T J, Wassen F W, Crescenzi A, da-Silva W S, Harney J, Engel F B, Obregon M J, Larsen P R, Bianco A C and Huang S A

  J Clin Invest; 2008 Mar 1. 118(3):975-983.

• Advances in measuring cellular bioenergetics using extracellular flux

  Ferrick D A, Neilson A and Beeson C

  Drug Discov Today; 2008 Mar 1. 13(40669):268-274.

• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27(2):433-446.

• Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons

  Ferrick D, Wu M, Swift A L and Neilson A

  Drug-Induced Mitochondrial Dysfunction; 2008 Jan 22. :Ch 14.

• ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart

  Alaynick W A, Kondo R P, Xie W, He W, Dufour C R, Downes M, Jonker J W, Giles W, Naviaux R K, Giguere V and Evans R M

  Cell Metab; 2007 Jul 1. 6(1):13-24.

• Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

  Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva W S, Espinoza D, Faucette R, Barry K, Bianco A C and Patti M E

  J Biol Chem; 2007 May 25. 282(21):15439-15450.

• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

  da-Silva W S, Harney J W, Kim B W, Li J, Bianco S D, Crescenzi A, Christoffolete M A, Huang S A and Bianco A C

  Diabetes; 2007 Mar 1. 56(3):767-776.

• The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

  Sridharan V, Guichard J, Bailey R M, Kasiganesan H, Beeson C and Wright G L

  Am J Physiol Cell Physiol; 2007 Feb 1. 292(2):C719-728.

• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292(1):C125-136.

• Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

  Watanabe M, Houten S M, Mataki C, Christoffolete M A, Kim B W, Sato H, Messaddeq N, Harney J W, Ezaki O, Kodama T, Schoonjans K, Bianco A C and Auwerx J

  Nature; 2006 Jan 26. 439(7075):484-489.

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Metabolic Adaptations in Fumarate Hydratase Deficient Cells

Christian Frezza, PhD,
Hutchison/MRC Research Centre, Cambridge, UK
May 29, 2013

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