Applications in Translational Medicine
App Notes & Tech Briefs
A real time assay that quantifies the ATP and biosynthetic demands of immune cell proliferation, differentiation and effector function.
Normal suspension cells, such as hematopoietic cells and lymphocytes are responsible for supplying oxygen to the body and protecting the host. Cellular metabolism is markedly dynamic in immune responses during proliferation and immune effector functions...Learn More
Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)
PLoS One; 2009 Dec 17. 4 (12):e8329.
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL
Cell Metab; 2010 May 5. 11 (5):412-426.
Endocrinology; 2010 Dec 15. 152 (2):556-567.
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain
J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.
Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease
J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.
Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.
Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes
Mitochondrion; 2011 Jul 1. 11 (4):615-619.
2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
PLoS One; 2011 Jul 1. 6 (7):e21788.
Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.
PLoS One; 2011 Aug 10. 6 (8):e23354.
Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
Proc Natl Acad Sci U S A; 2011 Aug 16. 108 (33):13829-13834.
Sci. Rep.; 2011 Aug 18. 1 (2011)
Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming
Stem Cells; 2011 Sep 1. 29 (9):1338-1348.
Biochimica et Biophysica Acta (BBA) - Bioenergetics; 2011 Nov 4.
Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells
PLoS One; 2011 Dec 15. 6 (12):e28536.
Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle
PLoS One; 2012 Jan 17. 7 (1):e30107.
Cell; 2012 Feb 17. 148 (4):716-726.
Mitochondrion; 2012 Mar 1. 12 (2):328-35.
The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance
J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.
Proc Natl Acad Sci U S A; 2012 Mar 27. 109 (13):4840-4845.
Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins
Exp Clin Endocrinol Diabetes; 2012 Apr 1. 120 (4):248-51.
J Med Genet; 2012 Apr 1. 49 (4):277-283.
Placenta; 2012 May 1. 33 (5):456-8.
Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations
Brain; 2012 May 1. 135 (Pt 5):1387-94.
Science; 2012 May 18. 336 (6083):918-22.
Inhibiting Systemic Autophagy during Interleukin 2 (IL-2) Immunotherapy Promotes Long-term Tumor Regression
Cancer Res; 2012 Jun 1. 72 (11):2791-801.
An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress
Aging Cell; 2012 Jun 1. 11 (3):520-29.
Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis
Am J Hum Genet; 2012 Jun 8. 90 (6):1079-87.
Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan
International Journal of Gerontology; 2012 Jun 8. 6 (2):122-126.
Diabetes; 2012 Aug 1. 61 (8):2146-54.
Placenta; 2012 Oct 1. 33 (10):816-23.
Mol Cancer; 2012 Oct 9. 11 (1):76.
Alteration of Fatty-Acid-Metabolizing Enzymes Affects Mitochondrial Form and Function in Hereditary Spastic Paraplegia
Am J Hum Genet; 2012 Dec 7. 91 (6):1051-64.
Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings
J Inherit Metab Dis; 2013 Jan 1. 36 (1):55-62.
Nature; 2013 Feb 7. 494 (7435):105-110.
Stem Cells. 2013 Feb 8; [Epub ahead of print].
Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood
Lab Invest. 2013 Mar 25; [Epub ahead of print].
J Biol Chem. 2013 Apr 18; [Epub ahead of print].
Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy
Human molecular genetics; 2013 May 3.
Increased Susceptibility to Reactive Oxygen Species in Autism Lymphoblastoid Cells is mediated by Mitochondrial Dysfunction
October 14-17, 2012
New Orleans, LA
Menadione-induced Oxidative Stress Modulates Mitochondrial Bioenergetics in Pancreatic Acinar Cells
International Congress on Cell Membranes and Oxidative Stress Focus on Calcium Signaling and TRP Channels 2012
June 26-29, 2012
Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness - Insights into Tissue-Specific Mechanisms
Keystone Symposia: Mitochondrial Dynamics and Function
March 19-24, 2012
Banff, Alberta, CA
Mitochondrial Bioenergetics in Disease: Toward a Mitochondrial Therapy of Muscular Dystrophies and Beyond
Paolo Bernardi, MD, University of Padova
September 15, 2009
Brian Polster, PhD, University of Maryland Medical School
August 19, 2009
How to Measure Mitochondrial Function in Whole Islets. Sensing the nutrient sensor: measuring bioenergetic parameters from intact mouse and human islets of langerhans
Orian Shirihai, MD, PhD, Boston University Medical Center
July 16, 2009
Craig Beeson, PhD , Medical University of South Carolina
June 24, 2009
Russell H. Swerdlow, MD, University of Kansas School of Medicine
March 16, 2009
Jon Nilsen, PhD, University of Southern California
June 25, 2008
Vamsi Mootha, MD, Harvard Medical School Center for Human Genetics, Massachusetts General Hospital
February 26, 2008
Translational medicine is an emerging field within medical research which seeks to draw inferences from research in basic biomedical sciences such as molecular and cell biology that are of significance for patient care. With its focus on removing barriers to multi-disciplinary collaboration, translational research has the potential to drive the advancement of applied science.
An attempt to bridge these barriers has been undertaken particularly in the medical domain where the term translational medicine has been applied to a research approach that seeks to move "from bench to bedside" or from laboratory experiments through clinical trials to actual point-of-care patient applications.
Enabling a greater understanding of cellular bioenergetics, the XF Analyzer allows the measurement of cellular metabolism in real time, in a microplate. By measuring the oxygen consumption rate (OCR)—a measure of mitochondrial respiration; as well as the extracellular acidification rate (ECAR)—a measure of glycolysis, you will be provided with the most physiologically relevant in vitro measurement for your bioenergetic studies.
- Cell Physiology
- Mitochondrial Diseases
- Model Organisms
- Obesity, Diabetes, & Metabolic Disorders
- Stem Cell Biology
- Toxicology & Hepatobiology
- Translational Medicine
Next Seahorse Webinar
Christian Frezza, PhD,
Hutchison/MRC Research Centre, Cambridge, UK
May 29, 2013
Advanced XF Training
Understanding When and How to Use Intact Cells and Isolated Mitochondria in Investigating Bioenergetics
XFe Extracellular Flux Analyzers
The world's most advanced cell metabolism analyzer.Learn More