Screening

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  • Screening for Mitochondrial Biogenesis and Toxicity

    A sensitive and robust cell-based screening assay.

    Mitochondrial damage compromises ATP production and consequentially cellular viability. Given the central role that mitochondria play in regulating cellular function, drugs that undermine mitochondrial function frequently elicit toxic effects...

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Preclinical screening for drug-induced mitochondrial dysfunction can predict toxicity and reduce attrition (or late stage failure) during drug development. Some new drugs may reach the market and their toxicity may not be discovered until many patients have been exposed. The unpredicted toxicity is due to the drug's adverse effects on mitochondrial function.

The XF Analyzer can facilitate preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue early in the drug development process. The XF Analyzer generates data that can provide new understanding in relation to mitochondrial dysfunction, by allowing the measurement of cellular metabolism in real-time, in a microplate. By measuring the oxygen consumption rate (OCR)—a measure of mitochondrial respiration; as well as the extracellular acidification rate (ECAR)—a measure of glycolysis, you will be provided with the most physiologically relevant in vitro measurement for your bioenergetic studies.