Applications in Obesity, Diabetes, & Metabolic Disorders

App Notes & Tech Briefs

• Measuring bioenergetic profiles of human adipocytes

  Measuring white adipose tissue (WAT) mitochondrial function reveals impaired fatty acid stimulated uncoupling from obese individuals

  White adipose tissue (WAT) is increasingly being recognized for its importance in regulating metabolic homeostasis, in addition to passive lipid storage. However, mature adipocytes and WAT are challenging to study because they are laden with lipid and float on top of media...

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• Measuring mitochondrial respiration in intact skeletal muscle fibers

  Assessment of mitochondrial function in skeletal muscle is a powerful tool for modeling neuromuscular conditions including muscular dystrophy, aging and cachexia. Similarly, skeletal muscle plays an important role in normal and pathological metabolism, such as obesity and diabetes. The majority of investigations use measurements of single mitochondrial enzymes as a surrogate to measuring mitochondrial function which does not provide a complete physiological readout of the mitochondria...

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• Measuring fatty acid oxidation in muscle cells

  A sensitive non-radiometric real-time assay of FAO

  Altered fatty acid metabolism by skeletal muscle can lead to insulin resistance and the accumulation of lipid in non-adipose tissue. This accumulation plays a critical role in the pathogenesis of chronic diseases including diabetes and heart failure...

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• Direct Comparison of Radiometric versus XF24 Flux Assays to Measure Substrate Utilization

  With accuracies comparable to those obtained with radiometric assays, the Seahorse XF24 Analyzer measures substrate utilization via extracellular fluxes of metabolites such as oxygen and protons to estimate metabolic fluxes due to mitochondrial respiration and glycolysis, respectively...

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• Analyzing microgram quantities of isolated mitochondria in the XF24 Analyzer

  Enhanced appreciation of the role of altered mitochondrial function in tumorigenesis, aging, neurodegenerative, metabolic, and cardiovascular diseases has stimulated the development of a variety of new approaches for assessing mitochondrial function and dysfunction. As the field moves towards the discovery of mitochondrial-related, molecular mechanisms that underlie disease, and drugs to prevent or reverse disease development, the demand for higher throughput and more sensitive assay methods increases...

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Publications

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• Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

  Watanabe M, Houten S M, Mataki C, Christoffolete M A, Kim B W, Sato H, Messaddeq N, Harney J W, Ezaki O, Kodama T, Schoonjans K, Bianco A C and Auwerx J

  Nature; 2006 Jan 26. 439 (7075):484-489.

• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

  da-Silva W S, Harney J W, Kim B W, Li J, Bianco S D, Crescenzi A, Christoffolete M A, Huang S A and Bianco A C

  Diabetes; 2007 Mar 1. 56 (3):767-776.

• Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

  Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva W S, Espinoza D, Faucette R, Barry K, Bianco A C and Patti M E

  J Biol Chem; 2007 May 25. 282 (21):15439-15450.

• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27 (2):433-446.

• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

  Feige J N, Lagouge M, Canto C, Strehle A, Houten S M, Milne J C, Lambert P D, Mataki C, Elliott P J and Auwerx J

  Cell Metab; 2008 Nov 1. 8 (5):347-358.

• AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

  Canto C, Gerhart-Hines Z, Feige J N, Lagouge M, Noriega L, Milne J C, Elliott P J, Puigserver P and Auwerx J

  Nature; 2009 Apr 23. 458 (7241):1056-1060.

• TGR5-mediated bile acid sensing controls glucose homeostasis

  Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J and Schoonjans K

  Cell Metab; 2009 Sep 1. 10 (3):167-177.

• C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

  Vernochet C, Peres S B, Davis K E, McDonald M E, Qiang L, Wang H, Scherer P E and Farmer S R

  Mol Cell Biol; 2009 Sep 1. 29 (17):4714-4728.

• KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

  Costanzo-Garvey D L, Pfluger P T, Dougherty M K, Stock J L, Boehm M, Chaika O, Fernandez M R, Fisher K, Kortum R L, Hong E G, Jun J Y, Ko H J, Schreiner A, Volle D J, Treece T, Swift A L, Winer M, Chen D, Wu M, Leon L R, Shaw A S, McNeish J, Kim J K, Morrison D K, Tschop M H and Lewis R E

  Cell Metab; 2009 Nov 1. 10 (5):366-378.

• Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue

  Kang H W, Ribich S, Kim B W, Hagen S J, Bianco A C and Cohen D E

  J Lipid Res; 2009 Nov 1. 50 (11):2212-2221.

• Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

  Malmgren S, Nicholls D G, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H and Sharoyko V V

  J Biol Chem; 2009 Nov 20. 284 (47):32395-32404.

• Insulin signaling regulates mitochondrial function in pancreatic beta-cells

  Liu S, Okada T, Assmann A, Soto J, Liew C W, Bugger H, Shirihai O S, Abel E D and Kulkarni R N

  PLoS One; 2009 Nov 24. 4 (11):e7983.

• Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77

  Chao L C, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva O R, Ding S Y, Reue K, Watt M J, Newgard C B, Pilch P F, Hevener A L and Tontonoz P

  Diabetes; 2009 Dec 1. 58 (12):2788-2796.

• The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α

  Zhong L, D'Urso A, Toiber D, Sebastian C, Henry R E, Vadysirisack D D, Guimaraes A, Marinelli B, Wikstrom J D, Nir T, Clish C B, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai O S, Ellisen L W, Espinosa J M and Mostoslavsky R

  Cell; 2010 Jan 22. 140 (2):280-293.

• A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

  Shaham O, Slate N G, Goldberger O, Xu Q, Ramanathan A, Souza A L, Clish C B, Sims K B and Mootha V K

  Proc Natl Acad Sci U S A; 2010 Jan 26. 107 (4):1571-1575.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11 (3):213-219.

• The homeobox protein Prox1 is a negative modulator of ERR{α}/PGC-1{α} bioenergetic functions

  Charest-Marcotte A, Dufour C R, Wilson B J, Tremblay A M, Eichner L J, Arlow D H, Mootha V K and Giguere V

  Genes Dev; 2010 Mar 15. 24 (6):537-542.

• Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

  Chakrabarti P, English T, Shi J, Smas C M and Kandror K V

  Diabetes; 2010 Apr 1. 59 (4):775-781.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

  Krus U, Kotova O, Spegel P, Hallgard E, Sharoyko V V, Vedin A, Moritz T, Sugden M C, Koeck T and Mulder H

  Biochem J; 2010 Jul 1. 429 (1):205-213.

• Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells, a novel role for glucose-6-phosphate dehydrogenase

  Mailloux R J and Harper M E

  FASEB J; 2010 Jul 1. 24 (7):2495-2506.

• High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy

  Trudeau K, Molina A J, Guo W and Roy S

  Am J Pathol; 2010 Jul 1. 177 (1):447-455.

• Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

  Ellis J M, Li L O, Wu P C, Koves T R, Ilkayeva O, Stevens R D, Watkins S M, Muoio D M and Coleman R A

  Cell Metab; 2010 Jul 4. 12 (1):53-64.

• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

  Chau M D, Gao J, Yang Q, Wu Z and Gromada J

  Proc Natl Acad Sci U S A; 2010 Jul 13. 107 (28):12553-12558.

• Wnt signaling regulates mitochondrial physiology and insulin sensitivity

  Yoon J C, Ng A, Kim B H, Bianco A, Xavier R J and Elledge S J

  Genes Dev; 2010 Jul 15. 24 (14):1507-1518.

• A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

  Pei W, Kratz L E, Bernardini I, Sood R, Yokogawa T, Dorward H, Ciccone C, Kelley R I, Anikster Y, Burgess H A, Huizing M and Feldman B

  Development; 2010 Aug 1. 137 (15):2587-2596.

• Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

  Philp A, Perez-Schindler J, Green C, Hamilton D L and Baar K

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C240-250.

• Respiration in adipocytes is inhibited by reactive oxygen species

  Wang T, Si Y, Shirihai O S, Si H, Schultz V, Corkey R F, Hu L, Deeney J T, Guo W and Corkey B E

  Obesity (Silver Spring); 2010 Aug 1. 18 (8):1493-1502.

• Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity

  Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson L S, Xiong J, Lanoue K F, Chang Z, Lynch C J, Wang H and Shi Y

  Cell Metab; 2010 Aug 4. 12 (2):154-165.

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

• Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis

  Hall J A, Ribich S, Christoffolete M A, Simovic G, Correa-Medina M, Patti M E and Bianco A C

  Endocrinology; 2010 Sep 1. 151 (9):4573-4582.

• Acute stimulation of white adipocyte respiration by PKA-induced lipolysis

  Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N and Collins S

  Diabetes; 2010 Oct 1. 59 (10):2474-2483.

• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

  Nasrin N, Wu X, Fortier E, Feng Y, Bare O C, Chen S, Ren X, Wu Z, Streeper R S and Bordone L

  J Biol Chem; 2010 Oct 15. 285 (42):31995-32002.

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

  Akhmedov D, Braun M, Mataki C, Park K S, Pozzan T, Schoonjans K, Rorsman P, Wollheim C B and Wiederkehr A

  FASEB J; 2010 Nov 1. 24 (11):4613-4626.

• Heart-type fatty acid binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance

  Vergnes L, Chin R, Young S G and Reue K

  J Biol Chem; 2010 Nov 1. 286 (1):380-390.

• Mechanisms of metformin action on glucose transport and metabolism in human adipocytes

  Grisouard J, Timper K, Radimerski T M, Frey D M, Peterli R, Kola B, Korbonits M, Herrmann P, Krahenbuhl S, Zulewski H, Keller U, Muller B and Christ-Crain M

  Biochem Pharmacol; 2010 Dec 1. 80 (11):1736-1745.

• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

  Schulz T J, Huang T L, Tran T T, Zhang H, Townsend K L, Shadrach J L, Cerletti M, McDougall L E, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland J L, Wagers A J and Tseng Y H

  Proc Natl Acad Sci U S A; 2011 Jan 4. 108 (1):143-148.

• A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

  Koeck T, Olsson A H, Nitert M D, Sharoyko V V, Ladenvall C, Kotova O, Reiling E, Ronn T, Parikh H, Taneera J, Eriksson J G, Metodiev M D, Larsson N G, Balhuizen A, Luthman H, Stancakova A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H and Ling C

  Cell Metab; 2011 Jan 5. 13 (1):80-91.

• The adipocyte-expressed forkhead transcription factor foxc2 regulates metabolism through altered mitochondrial function

  Lidell M E, Seifert E L, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng X R, Harper M E and Enerback S

  Diabetes; 2011 Feb 1. 60 (2):427-435.

• Wnt signaling regulates hepatic metabolism

  Liu H, Fergusson M M, Wu J J, Rovira, II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack M N and Finkel T

  Sci Signal; 2011 Feb 1. 4 (158):ra6.

• The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

  da-Silva W S, Ribich S, Drigo R A, Castillo M, Patti M E and Bianco A C

  FEBS Lett; 2011 Feb 4. 585 (3):539-544.

• Telomere dysfunction induces metabolic and mitochondrial compromise

  Sahin E, Colla S, Liesa M, Moslehi J, Muller F L, Guo M, Cooper M, Kotton D, Fabian A J, Walkey C, Maser R S, Tonon G, Foerster F, Xiong R, Wang Y A, Shukla S A, Jaskelioff M, Martin E S, Heffernan T P, Protopopov A, Ivanova E, Mahoney J E, Kost-Alimova M, Perry S R, Bronson R, Liao R, Mulligan R, Shirihai O S, Chin L and DePinho R A

  Nature; 2011 Feb 9. 470 (7334):359-365.

• Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration

  Gesta S, Bezy O, Mori M A, Macotela Y, Lee K Y and Kahn C R

  Proc Natl Acad Sci U S A; 2011 Feb 15. 108 (7):2771-2776.

• Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

  Fang S, Suh J M, Atkins A R, Hong S H, Leblanc M, Nofsinger R R, Yu R T, Downes M and Evans R M

  Proc Natl Acad Sci U S A; 2011 Feb 22. 108 (8):3412-3417.

• Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

  Affourtit C, Jastroch M and Brand M D

  Free Radic Biol Med; 2011 Mar 1. 50 (5):609-616.

• Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating

  Langhans W, Leitner C and Arnold M

  Am J Physiol Regul Integr Comp Physiol; 2011 Mar 1. 300 (3):R554-565.

• Inactivation of the mitochondrial carrier SLC25A25 (ATP-MG2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice

  Anunciado-Koza R P, Zhang J, Ukropec J, Bajpeyi S, Koza R A, Rogers R C, Cefalu W T, Mynatt R L and Kozak L P

  J Biol Chem; 2011 Apr 1. 286 (13):11659-11671.

• 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

  Kim Y I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N and Kawada T

  Mol Nutr Food Res; 2011 Apr 1. 55 (4):585-93.

• Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines

  Spegel P, Malmgren S, Sharoyko V V, Newsholme P, Koeck T and Mulder H

  Biochem J; 2011 Apr 1. 435 (1):277-284.

• Ncb5or deficiency increases fatty acid catabolism and oxidative stress

  Xu M, Wang W, Frontera J R, Neely M C, Lu J J, Aires D, Hsu F F, Turk J, Swerdlow R H, Carlson S E and Zhu H

  J Biol Chem; 2011 Apr 1. 286 (13):11141-11154.

• PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

  Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten S M, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve A A and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):450-460.

• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

  Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper R H, Schoonjans K, Schreiber V, Sauve A A, Menissier-de Murcia J and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):461-468.

• Activation of peroxisome proliferator-activated receptor-alpha enhances fatty acid oxidation in human adipocytes

  Lee J Y, Hashizaki H, Goto T, Sakamoto T, Takahashi N and Kawada T

  Biochem Biophys Res Commun; 2011 Apr 22. 407 (4):818-822.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets

  Jung S R, Kuok I T, Couron D, Rizzo N, Margineantu D H, Hockenbery D M, Kim F and Sweet I R

  J Biol Chem; 2011 May 20. 286 (20):17422-17434.

• High fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production

  Ruggiero C, Ehrenshaft M, Cleland E and Stadler K

  Am J Physiol Endocrinol Metab; 2011 Jun 1. 300 (6):1047-1058.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Activation of peroxisome proliferator-activated receptor-[alpha] (PPAR[alpha]) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes

  Kimura R, Takahashi N, Murota K, Yamada Y, Niiya S, Kanzaki N, Murakami Y, Moriyama T, Goto T and Kawada T

  Biochemical and Biophysical Research Communications; 2011 Jun 24. 410 (1):40549.

• Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

  Liu N, Bezprozvannaya S, Shelton J M, Frisard M I, Hulver M W, McMillan R P, Wu Y, Voelker K A, Grange R W, Richardson J A, Bassel-Duby R and Olson E N

  The Journal of Clinical Investigation; 2011 Jul 1. 121 (8):3258-3268.

• The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

  Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W J, Sereda S, Clerc P, Polster B M, Aja S M, Pletnikov M V, Kensler T W, Shirihai O S, Iijima M, Hussain M A and Sesaki H

  Mol Biol Cell; 2011 Jul 1. 22 (13):2235-2245.

• Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

  Souza S C, Chau M D, Yang Q, Gauthier M S, Clairmont K B, Wu Z, Gromada J and Dole W P

  Biochem Biophys Res Commun; 2011 Jul 8. 410 (3):398-403.

• Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells

  Diers A R, Broniowska K A, Darley-Usmar V M and Hogg N

  Am J Physiol Heart Circ Physiol; 2011 Sep 1. 301 (3):H803-812.

• A Peroxisome Proliferator-activated Receptor {gamma} (PPAR{gamma})/PPAR{gamma} Coactivator 1{beta} Autoregulatory Loop in Adipocyte Mitochondrial Function

  Deng T, Sieglaff D H, Zhang A, Lyon C J, Ayers S D, Cvoro A, Gupte A A, Xia X, Baxter J D, Webb P and Hsueh W A

  J Biol Chem; 2011 Sep 2. 286 (35):30723-30731.

• SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

  Koyama T, Kume S, Koya D, Araki S I, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H and Uzu T

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1258-1267.

• The PGC-1{alpha}-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

  Philp A, Belew M Y, Evans A, Pham D, Sivia I, Chen A, Schenk S and Baar K

  Am J Physiol Regul Integr Comp Physiol; 2011 Oct 1. 301 (4):R864-872.

• The differential role of hif1beta/arnt and the hypoxic response in adipose function, fibrosis, and inflammation

  Lee K Y, Gesta S, Boucher J, Wang X L and Kahn C R

  Cell Metab; 2011 Oct 5. 14 (4):491-503.

• Orexin is required for brown adipose tissue development, differentiation, and function

  Sellayah D, Bharaj P and Sikder D

  Cell Metab; 2011 Oct 5. 14 (4):478-490.

• Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

  Tormos K V, Anso E, Hamanaka R B, Eisenbart J, Joseph J, Kalyanaraman B and Chandel N S

  Cell Metab; 2011 Oct 5. 14 (4):537-544.

• Beta-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

  Robson-Doucette C A, Sultan S, Allister E M, Wikstrom J D, Koshkin V, Bhatacharjee A, Prentice K J, Sereda S B, Shirihai O S and Wheeler M B

  Diabetes; 2011 Nov 1. 60 (11):2710-2719.

• High Glucose Induces Mitochondrial Morphology and Metabolic Changes in Retinal Pericytes

  Trudeau K, Molina A J and Roy S

  Invest Ophthalmol Vis Sci; 2011 Nov 7. 52 (12):8657-64.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• Fatty Acids Suppress Autophagic Turnover in beta-Cells

  Las G, Serada S B, Wikstrom J D, Twig G and Shirihai O S

  J Biol Chem; 2011 Dec 9. 286 (49):42534-42544.

• Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

  Aguer C, Gambarotta D, Mailloux R J, Moffat C, Dent R, McPherson R and Harper M E

  PLoS One; 2011 Dec 15. 6 (12):e28536.

• The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2

  Gan Z, Burkart-Hartman E M, Han D H, Finck B, Leone T C, Smith E Y, Ayala J E, Holloszy J and Kelly D P

  Genes Dev; 2011 Dec 15. 25 (24):2619-30.

• Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

  Huang H P, Chen P H, Hwu W L, Chuang C Y, Chien Y H, Stone L, Chien C L, Li L T, Chiang S C, Chen H F, Ho H N, Chen C H and Kuo H C

  Hum Mol Genet; 2011 Dec 15. 20 (24):4851-64.

• Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice

  Ho L, Varghese M, Wang J, Zhao W, Chen F, Knable L A, Ferruzzi M and Pasinetti G M

  Nutr Neurosci; 2012 Jan 1. 15 (1):37-45.

• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

  Lee J Y, Takahashi N, Yasubuchi M, Kim Y I, Hashizaki H, Kim M J, Sakamoto T, Goto T and Kawada T

  Am J Physiol Cell Physiol; 2012 Jan 1. 302 (2):C463-472.

• Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics

  Mailloux R J, Adjeitey C N, Xuan J Y and Harper M E

  FASEB J; 2012 Jan 1. 26 (1):363-75.

• Programming human pluripotent stem cells into white and brown adipocytes

  Ahfeldt T, Schinzel R T, Lee Y K, Hendrickson D, Kaplan A, Lum D H, Camahort R, Xia F, Shay J, Rhee E P, Clish C B, Deo R C, Shen T, Lau F H, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten R E, Rinn J L and Cowan C A

  Nat Cell Biol; 2012 Jan 15. 14 (2):209-19.

• Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol

  Saadeh M, Ferrante T C, Kane A, Shirihai O, Corkey B E and Deeney J T

  PLoS One; 2012 Jan 17. 7 (1):e30200.

• Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

  Krishnan J, Danzer C, Simka T, Ukropec J, Walter K M, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, Pedrazzini T and Krek W

  Genes Dev; 2012 Feb 1. 26 (3):259-270.

• Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats

  Pung Y F, Rocic P, Murphy M P, Smith R A, Hafemeister J, Ohanyan V, Guarini G, Yin L and Chilian W M

  Arterioscler Thromb Vasc Biol; 2012 Feb 1. 32 (2):325-334.

• Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

  Park S J, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown A L, Kim M K, Beaven M A, Burgin A B, Manganiello V and Chung J H

  Cell; 2012 Feb 3. 148 (3):421-433.

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

  Bordicchia M, Liu D, Amri E Z, Ailhaud G, Dessi-Fulgheri P, Zhang C, Takahashi N, Sarzani R and Collins S

  J Clin Invest; 2012 Mar 1. 122 (3):1022-36.

• Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation

  Chen W, Chang B, Saha P, Hartig S M, Li L, Reddy V T, Yang Y, Yechoor V, Mancini M A and Chan L

  Mol Cell Biol; 2012 Mar 1. 32 (6):1099-1111.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.

• Pten positively regulates brown adipose function, energy expenditure, and longevity

  Ortega-Molina A, Efeyan A, Lopez-Guadamillas E, Munoz-Martin M, Gomez-Lopez G, Canamero M, Mulero F, Pastor J, Martinez S, Romanos E, Mar Gonzalez-Barroso M, Rial E, Valverde A M, Bischoff J R and Serrano M

  Cell Metab; 2012 Mar 7. 15 (3):382-394.

• Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

  Avila C, Huang R J, Stevens M V, Aponte A M, Tripodi D, Kim K Y and Sack M N

  Exp Clin Endocrinol Diabetes; 2012 Apr 1. 120 (4):248-51.

• Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes

  Morino K, Petersen K F, Sono S, Choi C S, Samuel V T, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg I J, Wang H, Eckel R H, Maegawa H and Shulman G I

  Diabetes; 2012 Apr 1. 61 (4):877-887.

• Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships

  Pathare P P, Lin A, Bornfeldt K E, Taubert S and Van Gilst M R

  PLoS Genet; 2012 Apr 1. 8 (4):e1002645.

• Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

  Sebastian D, Hernandez-Alvarez M I, Segales J, Sorianello E, Munoz J P, Sala D, Waget A, Liesa M, Paz J C, Gopalacharyulu P, Oresic M, Pich S, Burcelin R, Palacin M and Zorzano A

  Proc Natl Acad Sci U S A; 2012 Apr 3. 109 (14):5523-5528.

• Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

  Urban M J, Pan P, Farmer K L, Zhao H, Blagg B S J and Dobrowsky R T

  Experimental Neurology; 2012 May 1. 235 (1):388-96.

• A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

  Wikstrom J D, Sereda S B, Stiles L, Elorza A, Allister E M, Neilson A, Ferrick D A, Wheeler M B and Shirihai O S

  PLoS One; 2012 May 14. 7 (5):e33023.

• Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

  Fernandez-Marcos P J, Jeninga E H, Canto C, Harach T, de Boer V C, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten S M, Schoonjans K and Auwerx J

  Sci Rep; 2012 May 28. 2 (425)

• Peroxisome Proliferator-Activated Receptor gamma Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

  Hu S, Yao J, Howe A A, Menke B M, Sivitz W I, Spector A A and Norris A W

  Mol Endocrinol; 2012 Jun 1. 26 (6):977-988.

• Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

  Kiefer F W, Vernochet C, O'Brien P, Spoerl S, Brown J D, Nallamshetty S, Zeyda M, Stulnig T M, Cohen D E, Kahn C R and Plutzky J

  Nat Med; 2012 Jun 1. 18 (6):918-25.

• Cellular Responses to the Metal-Binding Properties of Metformin

  Logie L, Harthill J, Patel K, Bacon S, Hamilton D L, Macrae K, McDougall G, Wang H H, Xue L, Jiang H, Sakamoto K, Prescott A R and Rena G

  Diabetes; 2012 Jun 1. 61 (6):1423-33.

• Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

  Roy Chowdhury S K, Smith D R, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N A and Fernyhough P

  Brain; 2012 Jun 1. 135 (Pt 6):1751-66.

• Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats

  Betz M J, Bielohuby M, Mauracher B, Abplanalp W, Muller H H, Pieper K, Ramisch J, Tschop M H, Beuschlein F, Bidlingmaier M and Slawik M

  PLoS One; 2012 Jun 13. 7 (6):e38997.

• Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition

  Fink B D, Herlein J A, O'Malley Y and Sivitz W I

  PLoS One; 2012 Jun 22. 7 (6):e39430.

• Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

  Fournier B, Murray B, Gutzwiller S, Marcaletti S, Marcellin D, Bergling S, Brachat S, Persohn E, Pierrel E, Bombard F, Hatakeyama S, Trendelenburg A-U, Morvan F, Richardson B, Glass D J, Lach-Trifilieff E and Feige J N

  Molecular and Cellular Biology; 2012 Jul 1. 32 (14):2871-2879.

• BNip3 regulates mitochondrial function and lipid metabolism in the liver.

  Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon M C, Hart J, Dorn G W, 2nd, Brady M J and Macleod K F

  Mol Cell Biol; 2012 Jul 1. 32 (13):2570-84.

• Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

  Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung D Y, Ramsey J J, Kim J K, Cortopassi G, Havel P J and Haj F G

  Endocrinology; 2012 Jul 1. 153 (7):3158-3169.

• Acyl-CoA thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

  Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck C K, Genoud C, Cron P, Keusch J J, Dummler B, Esposti M D and Hemmings B A

  Mol Cell Biol; 2012 Jul 1. 32 (14):2685-97.

• Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

  Konstantopoulos N, Molero J C, McGee S L, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta V C, Krippner G, Andrikopoulos S and Walder K R

  Diabetes; 2012 Aug 1. 61 (8):2146-54.

• LRH-1-dependent glucose sensing determines intermediary metabolism in liver

  Oosterveer M H, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk T H, Ayuso E, Bosch F, Postic C, Groen A K, Auwerx J and Schoonjans K

  J Clin Invest; 2012 Aug 1. 122 (8):2817-26.

• Impact of high glucose and transforming growth factor-beta on bioenergetic profiles in podocytes

  Stieger N, Worthmann K, Teng B, Engeli S, Das A M, Haller H and Schiffer M

  Metabolism; 2012 Aug 1. 61 (8):1073-86.

• Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Ppargamma

  Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer S R and Accili D

  Cell; 2012 Aug 3. 150 (3):620-632.

• Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting

  Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial N N, Watkins S M and Hotamisligil G S

  PLoS Genet; 2012 Aug 23. 8 (8):e1002902.

• Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

  Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K and Saito M

  Cell Metab; 2012 Sep 5. 16 (3):394-406.

• MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

  Kusminski C M, Holland W L, Sun K, Park J, Spurgin S B, Lin Y, Askew G R, Simcox J A, McClain D A, Li C and Scherer P E

  Nat Med; 2012 Sep 9. 18 (10):1539-49.

• Zbtb16 has a role in brown adipocyte bioenergetics

  Plaisier C L, Bennett B J, He A, Guan B, Lusis A J, Reue K and Vergnes L

  Nutr Diabetes; 2012 Sep 17. 2 (9):e46.

• Protein carbonylation and adipocyte mitochondrial function

  Curtis J M, Hahn W S, Stone M D, Inda J J, Droullard D J, Kuzmicic J P, Donoghue M A, Long E K, Armien A G, Lavandero S, Arriaga E, Griffin T J and Bernlohr D A

  J Biol Chem; 2012 Sep 21. 287 (39):32967-32980.

• Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial beta-oxidation

  Gonzalez-Barroso M M, Anedda A, Gallardo-Vara E, Redondo-Horcajo M, Rodriguez-Sanchez L and Rial E

  Biochim Biophys Acta; 2012 Oct 1. 1817 (20):1768-75.

• Role of TRIB3 in Regulation of Insulin Sensitivity and Nutrient Metabolism during Short-term Fasting and Nutrient Excess

  Liu J, Zhang W, Chuang G C, Hill H S, Tian L, Fu Y, Moellering D R and Garvey W T

  Am J Physiol Endocrinol Metab; 2012 Oct 1. 303 (7):E908-16.

• TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

  Su X, Gi Y J, Chakravarti D, Chan I L, Zhang A, Xia X, Tsai K Y and Flores E R

  Cell Metab; 2012 Oct 3. 16 (4):511-525.

• Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

  Raichur S, Hooi Teh S, Ohwaki K, Gaur V, Chau Long Y, Hargreaves M, McGee S L and Kusunoki J

  J Mol Endocrinol; 2012 Oct 12. 49 (3):203-211.

• Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype

  Sansbury B E, Cummins T D, Tang Y, Hellmann J, Holden C R, Harbeson M A, Chen Y, Patel R P, Spite M R, Bhatnagar A and Hill B G

  Circ Res; 2012 Oct 12. 111 (9):1176-89.

• Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat

  Teperino R, Amann S, Bayer M, McGee S L, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young R S, Febbraio M A, Knauf C, Cani P D, Aberger F, Penninger J M, Pospisilik J A and Esterbauer H

  Cell; 2012 Oct 12. 151 (2):414-426.

• Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells

  Vaughan R A, Garcia-Smith R, Bisoffi M, Conn C A and Trujillo K A

  Lipids Health Dis; 2012 Oct 30. 11 (1):142.

• Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

  Jantzen K, Roursgaard M, Desler C, Loft S, Rasmussen L J and Moller P

  Mutagenesis; 2012 Nov 1. 27 (6):693-701.

• MyomiR-133 regulates brown fat differentiation through Prdm16

  Trajkovski M, Ahmed K, Esau C C and Stoffel M

  Nat Cell Biol; 2012 Nov 11. 14 (12):1330-1335.

• Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

  Mailloux R J, Fu A, Robson-Doucette C, Allister E, Wheeler M B, Screaton R and Harper M E

  J Biol Chem; 2012 Nov 16. 287 (47):39673-85.

• Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

  Chao L C, Wroblewski K, Ilkayeva O R, Stevens R D, Bain J, Meyer G A, Schenk S, Martinez L, Vergnes L, Narkar V A, Drew B G, Hong C, Boyadjian R, Hevener A L, Evans R M, Reue K, Spencer M J, Newgard C B and Tontonoz P

  J Lipid Res; 2012 Dec 1. 53 (12):2610-9.

• Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis

  Hagopian K, Tomilov A A, Tomilova N, Kim K, Taylor S L, Lam A K, Cortopassi G A, McDonald R B and Ramsey J J

  Metabolism; 2012 Dec 1. 61 (12):1703-13.

• Enhanced phosphoinositide 3-kinase(p110alpha) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

  Ritchie R H, Love J E, Huynh K, Bernardo B C, Henstridge D C, Kiriazis H, Tham Y K, Sapra G, Qin C, Cemerlang N, Boey E J, Jandeleit-Dahm K, Du X J and McMullen J R

  Diabetologia; 2012 Dec 1. 55 (12):3369-81.

• GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

  Tocchetti C G, Caceres V, Stanley B A, Xie C, Shi S, Watson W H, O'Rourke B, Spadari-Bratfisch R C, Cortassa S, Akar F G, Paolocci N and Aon M A

  Diabetes; 2012 Dec 1. 61 (12):3094-3105.

• Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

  Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin M J, An D, Lee K Y, Ilkayeva O R, Zingaretti C M, Emanuelli B, Smyth G, Cinti S, Newgard C B, Gibson B W, Larsson N G and Kahn C R

  Cell Metab; 2012 Dec 5. 16 (6):765-76.

• p62 Links beta-adrenergic input to mitochondrial function and thermogenesis

  Muller T D, Lee S J, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger K M, Hembree J, Heppner K M, Hofmann S, Holland J, Kuchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch A K, Schriever S C, Speakman J, Tseng Y H, Diaz-Meco M, Pfluger P T, Moscat J and Tschop M H

  J Clin Invest; 2013 Jan 2. 123 (1):469-478.

• Essential Roles of 11beta-HSD1 in regulating brown adipocyte function

  Liu J, Kong X, Wang L, Qi H, Di W, Zhang X, Wu L, Chen X, Yu J, Zha J, Lv S, Zhang A, Cheng P, Hu M, Li Y, Bi J, Hu F, Zhong Y, Xu Y and Ding G

  J Mol Endocrinol; 2013 Jan 11. 50 (1):103-113.

• Central Glucagon-Like Peptide 1 Receptor (Glp1r)-Induced Anorexia Requires Glucose Metabolism-Mediated Suppression of AMPK and is Impaired by Central Fructose

  Burmeister M A, Ayala J E and Drucker D J

  Am J Physiol Endocrinol Metab. 2013 Jan 22; [Epub ahead of print].

• Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice from High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

  Camporez J P, Jornayvaz F R, Lee H Y, Kanda S, Guigni B A, Kahn M, Samuel V T, Carvalho C R, Petersen K F, Jurczak M J and Shulman G I

  Endocrinology. 2013 Jan 30; [Epub ahead of print].

• Novel cell-based assay reveals associations of circulating serum AhR-ligands with metabolic syndrome and mitochondrial dysfunction

  Park W-H, Jun D W, Kim J T, Jeong J H, Park H, Chang Y-S, Park K S, Lee H K and Pak Y K

  BioFactors. 2013 Jan 30; [Epub ahead of print].

• Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

  Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot M L, Ruderman N B, Nolan C J, Joly E, Madiraju S R, Poitout V and Prentki M

  Diabetes. 2013 Feb 1; [Epub ahead of print].

• Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

  Liew C W, Boucher J, Cheong J K, Vernochet C, Koh H J, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng Y H, Hellerstein M K, Farmer S R, Goodyear L, Doria A, Bluher M, Hsu S I and Kulkarni R N

  Nat Med; 2013 Feb 1. 19 (2):217-26.

• Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet beta-Cells

  Nishiki Y, Adewola A, Hatanaka M, Templin A T, Maier B and Mirmira R G

  Mol Endocrinol; 2013 Feb 1. 27 (2):336-349.

• Ciliary neurotrophic factor activates NF-kappaB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

  Saleh A, Roy Chowdhury S K, Smith D R, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi K E, Calcutt N A and Fernyhough P

  Neuropharmacology; 2013 Feb 1. 2013 Feb (65):65-73.

• Knockdown of RyR3 Enhances Adiponectin Expression Through an atf3-Dependent Pathway

  Tsai S H, Chang E Y, Chang Y C, Hee S W, Tsai Y C, Chang T J and Chuang L M

  Endocrinology. 2013 Feb 6; [Epub ahead of print].

• An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice

  Reilly S M, Chiang S H, Decker S J, Chang L, Uhm M, Larsen M J, Rubin J R, Mowers J, White N M, Hochberg I, Downes M, Yu R T, Liddle C, Evans R M, Oh D, Li P, Olefsky J M and Saltiel A R

  Nat Med. 2013 Feb 10; [Epub ahead of print].

• Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity

  Bruckbauer A and Zemel M B

  Diabetes Metab Syndr Obes; 2013 Feb 13. 6 (93-102):2013.

• The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

  Chowdhury S K, Smith D R and Fernyhough P

  Neurobiol Dis; 2013 Mar 1.

• Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction

  Gero D, Szoleczky P, Suzuki K, Modis K, Olah G, Coletta C and Szabo C

  Diabetes; 2013 Mar 1. 62 (3):953-964.

• Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

  Lee S H, Jouihan H A, Cooksey R C, Jones D, Kim H J, Winge D R and McClain D A

  Endocrinology; 2013 Mar 1. 154 (3):1029-1038.

• Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARgamma Specifies Lipid Storage versus Thermogenic Gene Programs

  Villanueva C J, Vergnes L, Wang J, Drew B G, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener A L, Reue K, Fong L G, Young S G and Tontonoz P

  Cell Metab; 2013 Mar 5. 17 (3):423-435.

• Rosemary (Rosmarinus officinalis L.) extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells

  Tu Z, Moss-Pierce T, Ford P and Jiang A

  J Agric Food Chem. 2013 Mar 6; [Epub ahead of print].

• Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 beta-cells accompany functional adaptations to lipotoxicity

  Malmgren S, Spegel P, Danielsson A P, Nagorny C L, Andersson L E, Dekker Nitert M, Ridderstrale M, Mulder H and Ling C

  J Biol Chem. 2013 Mar 8; [Epub ahead of print].

• Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

  Ryu M J, Kim S J, Kim Y K, Choi M J, Tadi S, Lee M H, Lee S E, Chung H K, Jung S B, Kim H J, Jo Y S, Kim K S, Lee S H, Kim J M, Kweon G R, Park K C, Lee J U, Kong Y Y, Lee C H, Chung J and Shong M

  PLoS Genet; 2013 Mar 14. 9 (3):e1003356.

• Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation

  Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron A C, Kopp J, Yamamoto M and Noguchi C T

  Int J Biochem Cell Biol; 2013 Mar 20.

• Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

  Bachar-Wikstrom E, Wikstrom J D, Ariav Y, Tirosh B, Kaiser N, Cerasi E and Leibowitz G

  Diabetes; 2013 Apr 1. 62 (4):1227-1237.

• Methods for assessing mitochondrial function in diabetes

  Perry C G, Kane D A, Lanza I R and Neufer P D

  Diabetes; 2013 Apr 1. 62 (4):1041-1053.

• Ablation of Dihydroceramide Desaturase-1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

  Siddique M M, Ying L, Wang L, Jianhong C, Mal M, Ilkayeva O, Wu Y J, Bay B H and Summers S A

  Mol Cell Biol. 2013 Apr 1; [Epub ahead of print].

• Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

  Divakaruni A S, Wiley S E, Rogers G W, Andreyev A Y, Petrosyan S, Loviscach M, Wall E A, Yadava N, Heuck A P, Ferrick D A, Henry R R, McDonald W G, Colca J R, Simon M I, Ciaraldi T P and Murphy A N

  Proc Natl Acad Sci U S A; 2013 Apr 2. 110 (14):5422-7.

• Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis

  Segear Johnson E, Lindblom K R, Robeson A, Stevens R D, Ilkayeva O R, Newgard C B, Kornbluth S and Andersen J L

  J Biol Chem.. 2013 Apr 3; [Epub ahead of print].

• TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

  Settembre C, De Cegli R, Mansueto G, Saha P K, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jurgen Klisch T, Wollenberg A C, Di Bernardo D, Chan L, Irazoqui J E and Ballabio A

  Nature cell biology. 2013 Apr 21; [Epub ahead of print].

• Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKK[beta]

  Iseli T J, Turner N, Zeng X-Y, Cooney G J, Kraegen E W, Yao S, Ye Y, James D E and Ye J-M

  PloS one; 2013 Apr 25. 8 (4):e62309.

• Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

  Cypess A M, White A P, Vernochet C, Schulz T J, Xue R, Sass C A, Huang T L, Roberts-Toler C, Weiner L S, Sze C, Chacko A T, Deschamps L N, Herder L M, Truchan N, Glasgow A L, Holman A R, Gavrila A, Hasselgren P O, Mori M A, Molla M and Tseng Y H

  Nat Med; 2013 May 1. 19 (5):635-639.

Technical Posters

Sort by: Title | Author | Date

• LKB1 controls beta-cell mitochondrial homeostasis and insulin secretion

  Avital Swisa, Zvi Granot, Jakob Wikstrom and Yuval Dor

  Beta Cell Workshop 2013
  April 23-26, 2013
  Kyoto, JP

• Congenital hyperinsulinism and type 2 diabetes share involvement of DNA double strand breaks and p53 activity in beta-cells

  Sharona Tornovsky-Babeay, Daniela Dadon, Oren Ziv, et al.

  Beta Cell Workshop 2013
  April 23-26, 2013
  Kyoto, JP

• Bioenergetic characterization of adipogenesis impaired by inflammation

  Esposito D, Wilson M, Holway H, komarnytsky S

  Experimental Biology 2013
  April 20-24, 2013
  Boston, MA

• Impaired oxygen consumption in osteoblasts leads to reduced bone formation and low bone mass in IRS1 mutant mice.

  Guntur Anyonya, Victoria Demambro and Clifford Rosen

  Gordon Research Conference: Insulin-Like Growth Factors in Physiology & Disease
  March 17-22, 2013
  Ventura, CA

• Utilizing iPS cells to study the impact of genetically determined insulin resistance on cellular metabolism

  Alison Burkart, Salvatore Iovino, Kristina Kriauciunas, Youn-Kyoung Lee, Laura Warren, Chad Cowan, Mary-Elizabeth Patti and C. Ron Kahn

  Keystone Symposium: Diabetes - New Insights into Mechanism of Disease and its Treatment
  January 27-1, 2013
  Keystone, CO

• Differential LMNA splicing leads to metabolic disorders

  I C Lopez-Mejia, M De Toledo, C Chavey, P Cavelier, F Casas, G Barangare, EZ Amri, L Fajas, J Tazi

  Keystone Symposium: Adipose Tissue Biology
  January 27-1, 2013
  Keystone, CO

• Fat depot-dependent differences in bioenergetics of white adipocyte mitochondria

  A Anderson; P Roberts; R McMillan; M Frisard; T Brown; M Lawless; M Hulver; E Schmelz

  Keystone Symposium: Adipose Tissue Biology
  January 27-1, 2013
  Keystone, CO

• Increased Adipose Tissue Mitochondrial Oxidation Protects Mice against Obesity and Insulin resistance

  Vernochet C, Mourier A, Cinti S, Larson NG, Kahn CR.

  Keystone Symposium: Diabetes – New Insights into Mechanism of Disease and its Treatment
  January 27-1, 2013
  Keystone, CO

• Metabolic remodeling of white adipose tissue in obesity

  Timothy D. Cummins, Brian E. Sansbury, Candice R. Holden, Aruni Bhatnagar and Bradford G. Hill

  Society for Free Radical Biology and Medicine (SFRBM 2012)
  November 15-18, 2012
  San Diego, CA

• The Role of Mitochondrial Genetic Background on Mitochondrial Bioenergetics and Energy Balance

  Kimberly Dunham-Snary, David Westbrook, Melissa Sammy, William Ratcliffe, Betty Pat, Martin Young, Scott Ballinger

  Society for Free Radical Biology and Medicine (SFRBM 2012)
  November 15-18, 2012
  San Diego, CA

• Endothelial Nitric Oxide Synthase Prevents Obesity by Promoting Futile Protein Turnover

  Brian Sansbury, Timothy Cummins, Matthew Harbeson, Aruni Bhatnagar, Bradford G Hill

  Society for Free Radical Biology and Medicine (SFRBM 2012)
  November 15-18, 2012
  San Diego, CA

• Cisd2 deficiency leads to impaired differentiation and function of adipocytes in mice

  Chih-Hao Wang, Yi-Fan Chen, Chia-Yu Wu, Ting-Fen Tsai and Yau-Huei Wei

  9th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
  November 2-5, 2012
  Beijing, CN

• Myotubes derived from obese non-diabetic subjects with a family history of type 2 diabetes present mitochondrial defects with no sign of insulin resistance

  C. Aguer, M. Pasqua, R. Zhang, R. Dent, R. McPherson, M.E. Harper

  Obesity 2012
  September 20-24, 2012
  San Antonio, TX

• Intracellular acetyl CoA concentrations in the regulation of mitochondrial biogenesis, autophagy, dynamics and function

  Michael Tarpey, Matthew Hulver and Madlyn Frisard

  Obesity 2012
  September 20-24, 2012
  San Antonio, TX

• Age and High Fat Diet Associated Changes in Mitochondrial ROS Production in the Liver

  Kerstin Haas, Martin Klingenspor

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• Molecular characterization of nonshivering thermogenesis in a 'protoendothermic' mammal, the Lesser hedgehog tenrec (Echinops telfairi)

  Rebecca Oelkrug, Nadja Goetze, Cornelia Exner, Rebecca Oelkrug, Nadja Goetze, Goutham Ganjam, Gerhard Heldmaier, Martin Jastroch, Carola Meyer

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• Bioenergetic profiling of white adipocyte mitochondria

  Theresa Schoettl, Lisa Kappler, Verena Hirschberg, Tobias Fromme, Martin Klingenspor

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• Probing the involvement of mitochondria in the cytotoxic and cytoprotective effects of fatty acids in INS-1 insulinoma cells.

  Jonathan Barlow, Charles Affouritit and Noel Morgan

  EMBO|EMBL Symposium Diabetes and Obesity
  September 13-16, 2012
  Heidelberg, DE

• Effect of glucose concentration on mitochondrial metabolism of C2C12 cells

  Moustafa Elkalaf, Michal Andel and Jan Trnka

  EMBO|EMBL Symposium Diabetes and Obesity
  September 13-16, 2012
  Heidelberg, DE

• Palmitate causes mitochondrial DNA damage and mitochondrial dysfunction in skeletal muscle cells

  Jana Patkova, Jan Trnka, Adela Bojarova, Michal Andel

  EMBO|EMBL Symposium Diabetes and Obesity
  September 13-16, 2012
  Heidelberg, DE

• Fenofibrate Increases Lipid Metabolism in Human Skeletal Muscle

  Kristen E. Boyle, Joseph A. Houmard, Jed E. Friedman & Neda Rasouli

  American Diabetes Association 72nd Scientific Sessions (ADA 2012)
  June 8-12, 2012
  Philadelphia, PA

• Carnitine Palmitoyltransferase-1 Deficiency Impairs Fatty Acid Oxidation in Skeletal Muscle, but Preserves Insulin Sensitivity

  Shawna E. Wicks, Kimberly R. Haynie, Bolormaa Vandanmagsar, Jingying Zhang, Randall L. Mynatt

  American Diabetes Association 72nd Scientific Sessions (ADA 2012)
  June 8-12, 2012
  Philadelphia, PA

• Retinaldehyde dehydrogenase 1 is a novel regulator of brown fat function in white adipose tissue

  Florian W. Kiefer, Cecile Vernochet, Patrick O’Brien, Steffen Spoerl, Jonathan D. Brown, C. Ronald Kahn, Jorge Plutzky

  19th European Congress on Obesity
  May 9-12, 2012
  Lyon, France

• Effect of Obesity on Mitochondrial Function and Hypoxia Susceptibility in Human Syncytiotrophoblasts

  J. Mele Ph.D., A. Maloyan Ph.D., and L. Myatt PhD.

  Society for Gynecological Investigation (SGI) 2012
  March 21-24, 2012
  San Diego, CA

• Reduction of Malate Dehydrogenase Expression Blunts Activation of the AMPK Signaling Pathway

  Alison Burkart, Deborah Lee, Allison Goldfine, Manway Liu, Simon Kasif, Utsav Patel, Carles Lerin, and Mary-Elizabeth Patti

  Keystone Symposia Pathogenesis of Diabetes: Emerging Insights into Molecular Mechanisms
  January 29-3, 2012
  Santa Fe, NM

• STARS Regulates AMPK Phosphorylation and Oxidative Capacity

  Wen Kong, Alison Burkart, Michael Chen, Wanzhu Jin, Michael Hirshman, Laurie Goodyear, Mary Ellen Harper, C.G. Teg Pipes, Rhonda Bassel-Duby, Eric Ols

  Keystone Symposia: Genetic and Molecular Basis of Obesity and Body Weight Regulation
  January 29-3, 2012
  Santa Fe, NM

• Deletion of Bone Morphogenetic Protein Receptor 1a (BMPR1a) in POMC Neurons Results in Hyperphagia and Increased Sympathetic Outflow to Brown and Whit

  Kristy Townsend, Marla Diakow, Tian Lian Huang, Lindsay McDougall, Yuji Mishina, Yu-Hua Tseng

  Keystone Symposia: Genetic and Molecular Basis of Obesity and Body Weight Regulation
  January 29-3, 2012
  Santa Fe, NM

• Mitochondria Dysfunction created by Deletion of TFAM in Adipose Tissues Paradoxically Protects Mice against Obesity and Insulin resistance.

  Vernochet C., Bezy O. , Kahn CR

  Keystone Symposia Pathogenesis of Diabetes: Emerging Insights into Molecular Mechanisms
  January 29-3, 2012
  Santa Fe, NM

• Mitochondrial dynamics play a key role in brown adipocyte activation

  Jakob D Wikstrom, Samuel B Sereda, Yaguang Si, Marc Liesa, Guy Las, Gilad Twig, Kiana Mahdaviani, Barbara Corkey, Barbara Cannon, Jan Neder

  Mitochondrial Physiology and Medicine
  September 7-11, 2011
  Woods Hole, MA

• Selective over expression of toll-like receptor 4 in skeletal muscle causes impaired adaptation to high-fat feeding

  Ryan McMillan, Yaru Wu, Kevin Voelker, John Kavanaugh, Kristin Wahlberg, Angela Anderson, Kim Haynie, Madlyn Frisard, and Matthew Hulver

  American Diabetes Association 71st Scientific Sessions
  June 24-28, 2011
  San Diego, CA

• Deletion of the Mitochondrial Transcription Factor A (TFAM) in Adipose Tissue Causes Mitochondrial Dysfunction and Protects Mice from Obesity and Insulin Resistance

  American Diabetes Association 71st Scientific Sessions
  June 24-28, 2011
  San Diego, CA

• The role of toll-like receptor 4 in mitochondrial function and reactive oxygen species (ROS) production in skeletal muscle

  Yaru Wu, Madlyn Frisard, Elike Shabrokh, Kevin Voelker, Ryan P McMilian, Matthew W Hulver

  Experimental Biology 2011
  April 9-13, 2011
  Washington, DC, US

• Effect of Diabetes Mellitus on Mitochondrial Oxygen Consumption in Peripheral Blood Mononuclear Cells

  Hartman M, Levy V, Xu G, Frame A, Caiano T, Kluge M, Tabit C, Dohadwala M, Shah A, Kocherla M, Levitt A, Kim B, Duess M, Shenouda S, Holbrook M, Hambu

  D-Cure's 5th Annual Symposium
  March 29-30, 2011
  Tel Aviv, Israel

• The CREB coactivators, Crtc2 and Crtc3 Function as Exercise Mimetics in Skeletal Muscle

  Nelson E. Bruno, Antonio L. Ameilo, Mariam B. Lawani and Michael D. Conkright.

  Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  January 13-15, 2011
  Keystone, CO, US

• HSP72 preserves insulin sensitivity and prevents peripheral tissue lipotoxicity by increasing oxidative metabolism in skeletal muscle

  DC Henstridge, CR Bruce, BG Drew, N Watson, J Chung, V Ribas, SW Beaven, MJ Watt, M Hargreaves, SL McGee, MA Febbraio, AL Hevener

  Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  January 13-15, 2011
  Keystone, CO, US

• Class IIa histone deacetylases contribute to skeletal muscle transcriptional and metabolic remodeling and oxidative stress in insulin resistance

  Courtney Swinton, Shona Morrison, Tim Connor, Ken Walder, Greg R. Steinberg, Mark Hargreaves and Sean L. McGee

  Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  January 13-15, 2011
  Keystone, CO, US

• Chronic hyperglycemia - induced attenuation of mitochondrial reserve capacity mediates mesangial cell dysfunction in diabetes

  Balu K Chacko, Colin Reily, Gloria A Benavides, Michelle S. Johnson, and Victor M. Darley-Usmar

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL, US

• Differential regulation of metabolic pathways by Snitrosation in endothelial cells

  Anne R. Diers, Katarzyna A. Broniowska and Neil Hogg

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL, US

• The Mesodermal Developmental Gene Tbx15 Regulates Triglyceride Accumulation and Mitochondria Respiration in Adipocytes

  Obesity 2010
  October 11, 2010
  San Diego, CA

• Islet respiratory leak is acutely regulated by nutrients and ROS and is dysregulated in the obese state

  Jakob D Wikstrom, Alvaro Elorza, Emma M Allister, Samuel B Sereda, Linsey Stiles, Andy Neilson, David A Ferrick, Michael B Wheeler, Shaoping Deng, Orian S Shirihai

  European Association for the Study of Diabetes Annual Meeting
  September 20-24, 2010
  Stockholm, Sweden

• Brown adipocyte activation is characterized by a wave of mitochondrial fission and depolarization that is dependent on [Beta]3 receptor stimulation and Drp1, and is characterized by complete, but reversible, arrest of fusion

  Samuel B Sereda, Jakob D. Wikstrom, Yaguang Si, Gilad Twig, Marc Liesa, Guy Las, Cannon B, Nedergaard J, and Orian S. Shirihai

  Brown Adipose Tissue and Human Obesity Conference
  July 10, 2010
  Stockholm, Sweden

• The Homeobox Protein Prox1 is a Negative Modulator of ERR[Alpha]/PGC-1[Alpha] Bioenergetic Functions

  Alexis Charest-Marcotte, Catherine R. Dufour, Brian J. Wilson, Annie M. Tremblay, Lillian J. Eichner, Daniel H. Arlow, Vamsi K. Mootha and Vincent Gigu

  Nuclear Receptors: Development, Physiology and Disease
  March 21-26, 2010
  Keystone, CO, US

• Glucose availability modulates mitochondrial sources of NADPH in skeletal muscle cells: Implications for oxidative stress

  Ryan J. Mailloux and Mary-Ellen Harper

  Charleston Conference on Mitochondria Physiology and Pathobiology
  November 16, 2009
  Isle of Palms, NC, US

• Novel Islet Respirometry Assay Reveals High Levels of Uncoupled Respiration in Islets

  Jakob Wikstrom, Alvaro Elorza, Emma M Allister, Samuel B Sereda, Linsey Stiles, Andy Neilson, David A Ferrick, Michael B Wheeler, Shaoping Deng, Orian S Shirihai

  Charleston Conference on Mitochondria Physiology and Pathobiology
  November 16, 2009
  Isle of Palms, NC, US

• [Beta]-Adrenergic and cAMP-Stimulated Mitochondrial Uncoupling in Human Adipocytes

  Einav Yehuda-Shnaidman, Naresh Kumar, Ben Buehrer, Sheila Collins

  69th Scientific Sessions of the American Diabetes Association
  June 5-9, 2009
  New Orleans, LA, US

• Metformin-Induced Inhibition of Mitochondrial Complex I Activity Stimulates Fatty Acid Oxidation and Glycolysis While Blunting Glucose Oxidation in C2C12 Myocytes

  Min Wu, Amy L. Swift, Rebecca Moran and David A. Ferrick

  Gordon Research Conference: Molecular & Cellular Bioenergetics
  June 17, 2007
  Andover, NH

• A Novel, Non-Radioactive Method for Measuring Fatty Acid Oxidation and Cellular Metabolism in C2C12 Myocytes

  Mark E. Rothenberg, Tina Patel, Chris Braun, Suzanne Armitstead, Kristie Lemire, Rebecca Moran, Craig Beeson, David A. Ferrick

  Endocrine Society 2006 Annual Meeting
  June 24, 2006
  Boston, MA

• Extracellular Flux as an Indicator of Cellular Metabolism

  Chris Braun, Mark Rothenberg, Suzanne Armitstead, Kristie Lemire, Diane Parslow, Tina Patel, and David Ferrick

  NAASO Annual Meeting
  October 15, 2005
  Vancouver, BC, CA

Webinars

Sort by: Title | Speaker | Date
• 

  Mitochondrial Bioenergetics in Diabetic Cardiomyopathy

  E. Dale Abel MD PhD, University of Utah School of Medicine
  December 14, 2011

• 

  Biochemical analysis in C. elegans as a model for metabolic disease and aging

  Laurent Mouchiroud, PhD, École Polytechnique Fédérale de Lausanne
  Riekelt H. Houtkooper, PhD, École Polytechnique Fédérale de Lausanne
  November 30, 2011

• 

  Using Reserve Capacity to Screen for Mitochondrial Toxicities and Biogenesis

  Craig C. Beeson, PhD, Medical University of South Carolina
  March 23, 2011

• 

  New dimensions in adipocyte metabolism: Using the XF to probe human and rodent adipocytes and adipose tissue

  Sheila Collins, PhD, Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute
  Einav Yehuda-Shnaidman PhD, RD, The Hebrew University of Jerusalem
  February 9, 2011

• 

  Molecular Scaffolds KSR1/2: Implications for Obesity and Cancer

  Robert Lewis, PhD, University of Nebraska Cancer Center
  March 24, 2010

• 

  How to Measure Mitochondrial Function in Whole Islets. Sensing the nutrient sensor: measuring bioenergetic parameters from intact mouse and human islets of langerhans

  Orian Shirihai, MD, PhD, Boston University Medical Center
  July 16, 2009

• 

  The Bioenergetics of Obesity: New Approaches to Characterize Genes Affecting Energy Balance in Mouse Models

  Karen Reue, PhD, David Geffen School of Medicine at UCLA
  April 30, 2009

• 

  Tutorial: Measuring Bioenergetics in a Variety of Cell Types

  David Ferrick, PhD, CSO, Seahorse Bioscience
  July 17, 2008

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