Applications in Neurodegeneration

App Notes & Tech Briefs

• Bioenergetic Analysis of Primary Neuronal Deficiencies

  Sensitive assay to measure mitochondrial dysfunction characteristic of Parkinson's, Huntington's and other neurodegenerative diseases

  Mitochondria play central roles in meeting the demands of neuronal synapses for energy (ATP). Mitochondrial dysfunction results in impaired neuroplasticity, neuronal degeneration and cell death, and is now recognized as a key element in neurodegenerative diseases...

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• Assessing mitochondrial dysfunction in primary cardiomyocytes

  Mitochondrial reserve capacity is a sensitive measure of cellular stress

  This Application Note describes a method for profiling mitochondrial function in cells responding to stress. The mitochondrial profile generated in this way provides four parameters of mitochondrial function that can be measured in one experiment...

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• Screening for Mitochondrial Biogenesis and Toxicity

  A sensitive and robust cell-based screening assay.

  Mitochondrial damage compromises ATP production and consequentially cellular viability. Given the central role that mitochondria play in regulating cellular function, drugs that undermine mitochondrial function frequently elicit toxic effects...

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• Analyzing microgram quantities of isolated mitochondria in the XF24 Analyzer

  Enhanced appreciation of the role of altered mitochondrial function in tumorigenesis, aging, neurodegenerative, metabolic, and cardiovascular diseases has stimulated the development of a variety of new approaches for assessing mitochondrial function and dysfunction. As the field moves towards the discovery of mitochondrial-related, molecular mechanisms that underlie disease, and drugs to prevent or reverse disease development, the demand for higher throughput and more sensitive assay methods increases...

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Publications

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• Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

  Choi S W, Gerencser A A and Nicholls D G

  J Neurochem; 2009 May 1. 109 (4):1179-1191.

• Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

  Yao J, Irwin R W, Zhao L, Nilsen J, Hamilton R T and Brinton R D

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14670-14675.

• Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

  Swerdlow R H

  Pharmaceuticals; 2009 Dec 3. 2 (3):150-167.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration

  Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P and Nicotera P

  Hum Mol Genet; 2010 May 1. 19 (9):1669-1677.

• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

  Irwin R W, Yao J, Ahmed S S, Hamilton R T, Cadenas E and Brinton R D

  Endocrinology; 2010 Dec 15. 152 (2):556-567.

• KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

  Brustovetsky T, Brittain M K, Sheets P L, Cummins T R, Pinelis V and Brustovetsky N

  Br J Pharmacol; 2011 Jan 1. 162 (1):255-270.

• Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

  Varghese M, Zhao W, Wang J, Cheng A, Qian X, Chaudhry A, Ho L and Pasinetti G

  Translational Neuroscience; 2011 Jan 5. 2 (1)

• Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction

  Kim Y H, Lussier S, Rane A, Choi S W and Andersen J K

  Neuroscience; 2011 Jan 13. 172 (1):379-386.

• Meclizine is neuroprotective in models of Huntington's disease

  Gohil V M, Offner N, Walker J A, Sheth S A, Fossale E, Gusella J F, Macdonald M E, Neri C and Mootha V K

  Hum Mol Genet; 2011 Jan 15. 20 (2):294-300.

• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

  Chen H K, Ji Z S, Dodson S E, Miranda R D, Rosenblum C I, Reynolds I J, Freedman S B, Weisgraber K H, Huang Y and Mahley R W

  J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.

• Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

  Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C and Zeviani M

  Nat Genet; 2011 Mar 1. 43 (3):259-263.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system

  Sauerbeck A, Pandya J, Singh I, Bittman K, Readnower R, Bing G and Sullivan P

  Journal of Neuroscience Methods; 2011 Mar 15. 198 (1):36-43.

• Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: Antagonism by progesterone

  Yao J, Chen S, Cadenas E and Brinton R D

  Brain Res; 2011 Mar 16. 1379 (1):40584.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

  Flynn J M, Choi S W, Day N U, Gerencser A A, Hubbard A and Melov S

  Free Radic Biol Med; 2011 Apr 1. 50 (7):866-873.

• Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

  Wen Y, Li W, Poteet E C, Xie L, Tan C, Yan L J, Ju X, Liu R, Qian H, Marvin M A, Goldberg M S, She H, Mao Z, Simpkins J W and Yang S H

  J Biol Chem; 2011 May 6. 286 (18):16504-16515.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H(2) O(2)

  Cantu D, Fulton R E, Drechsel D A and Patel M

  J Neurochem; 2011 Jul 1. 118 (1):79-92.

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

  Yao J, Chen S, Mao Z, Cadenas E and Brinton R D

  PLoS One; 2011 Jul 1. 6 (7):e21788.

• DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

  McGee S L, Sadli N, Morrison S, Swinton C and Suphioglu C

  Cell Physiol Biochem; 2011 Aug 26. 28 (1):157-162.

• DJ-1 knock-down impairs astrocyte mitochondrial function

  Larsen N J, Ambrosi G, Mullett S J, Berman S B and Hinkle D A

  Neuroscience; 2011 Nov 24. (196):251-64.

• Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

  Dagda R K, Gusdon A M, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra S J, 3rd and Chu C T

  Cell Death Differ; 2011 Dec 1. 18 (12):1914-23.

• Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

  Schneider L, Giordano S, Zelickson B R, Johnson M, Benavides G, Ouyang X, Fineberg N, Darley-Usmar V M and Zhang J

  Free Radical Biology and Medicine; 2011 Dec 1. 51 (11):2007-17.

• Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

  Schuh R A, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H and Polster B M

  J Neurosci Res; 2011 Dec 1. 89 (12):1979-1988.

• Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function

  Irwin R W, Yao J, To J, Hamilton R T, Cadenas E and Brinton R D

  J Neuroendocrinol; 2012 Jan 1. 24 (1):236-248.

• ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

  Gusdon A M, Zhu J, Van Houten B and Chu C T

  Neurobiol Dis; 2012 Mar 1. 45 (3):962-72.

• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

  Liang L P, Waldbaum S, Rowley S, Huang T T, Day B J and Patel M

  Neurobiol Dis; 2012 Mar 1. 45 (3):1068-76.

• Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

  Sauerbeck A, Hunter R, Bing G and Sullivan P G

  Exp Neurol; 2012 Mar 1. 234 (1):85-94.

• Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency

  Alavian K N, Dworetzky S I, Bonanni L, Zhang P, Sacchetti S, Mariggio M A, Onofrj M, Thomas A, Li H, Mangold J E, Signore A P, Demarco U, Demady D R, Nabili P, Lazrove E, Smith P J, Gribkoff V K and Jonas E A

  Brain Res; 2012 Mar 29. (1446):1-11.

• Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts

  Richardson T E, Yu A E, Wen Y, Yang S-H and Simpkins J W

  PLoS One; 2012 Apr 3. 7 (4):e34600.

• Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

  Clerc P and Polster B M

  PLoS One; 2012 Apr 4. 7 (3):e34465.

• Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

  Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P C, Minor R K, Wilson Iii D M, Cooper M, Spencer R, de Cabo R, Croteau D L and Bohr V A

  J Exp Med; 2012 Apr 9. 209 (4):855-869.

• Sustained expression of PGC-1alpha in the rat nigrostriatal system selectively impairs dopaminergic function

  Ciron C, Lengacher S, Dusonchet J, Aebischer P and Schneider B L

  Hum Mol Genet; 2012 Apr 15. 21 (8):1861-76.

• BAD-Dependent Regulation of Fuel Metabolism and K(ATP) Channel Activity Confers Resistance to Epileptic Seizures

  Gimenez-Cassina A, Martinez-Francois J R, Fisher J K, Szlyk B, Polak K, Wiwczar J, Tanner G R, Lutas A, Yellen G and Danial N N

  Neuron; 2012 May 24. 74 (4):719-730.

• Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP(+) toxicity: dual roles for ERK1/2

  Zhu J H, Gusdon A M, Cimen H, Van Houten B, Koc E and Chu C T

  Cell Death Dis; 2012 May 24. 3 (e312)

• Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

  Roy Chowdhury S K, Smith D R, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N A and Fernyhough P

  Brain; 2012 Jun 1. 135 (Pt 6):1751-66.

• Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

  Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon V P, Bixby J L, Gereben B and Bianco A C

  The Journal of Neuroscience; 2012 Jun 20. 32 (25):8491-8500.

• Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

  Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean J R, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti R J, Huang Z, Opala G, Scarffe L A, Dawson V L, Klein C, Feng J, Ross O A, Trojanowski J Q, Lee V M, Marder K, Surmeier D J, Wszolek Z K, Przedborski S, Krainc D, Dawson T M and Isacson O

  Sci Transl Med; 2012 Jul 4. 4 (141):141ra190.

• Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

  Giaime E, Yamaguchi H, Gautier C A, Kitada T and Shen J

  PLoS One; 2012 Jul 9. 7 (7):e40501.

• Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid

  Yao J, Irwin R, Chen S, Hamilton R, Cadenas E and Brinton R D

  Neurobiol Aging; 2012 Aug 1. 33 (8):1507-1521.

• Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

  An M C, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S and Ellerby L M

  Cell Stem Cell; 2012 Aug 3. 11 (2):253-63.

• Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

  Siddiqui A, Chinta S J, Mallajosyula J K, Rajagopolan S, Hanson I, Rane A and Andersen J K

  Free Radical Biology and Medicine; 2012 Aug 15. 53 (4):993-1003.

• Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

  Walls K C, Coskun P, Gallegos-Perez J L, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green K N and Laferla F M

  J Biol Chem; 2012 Aug 31. 287 (36):30317-30327.

• Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: Lack of correlation with superoxide generation

  Dranka B P, Zielonka J, Kanthasamy A G and Kalyanaraman B

  J Neurochem; 2012 Sep 1. 122 (5):941-51.

• Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

  Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper R H, Auwerx J, Franken P and Tafti M

  J Neurosci; 2012 Sep 5. 32 (36):12506-12517.

• Mitochondrial DNA damage Is associated with reduced mitochondrial bioenergetics in Huntington's disease

  Siddiqui A, Rivera-Sánchez S, Castro M d R, Acevedo-Torres K, Rane A, Torres-Ramos C A, Nicholls D G, Andersen J K and Ayala-Torres S

  Free Radic Biol Med; 2012 Oct 1. 53 (7):1478-88.

• Methylene blue as a cerebral metabolic and hemodynamic enhancer

  Lin A L, Poteet E, Du F, Gourav R C, Liu R, Wen Y, Bresnen A, Huang S, Fox P T, Yang S H and Duong T Q

  PLoS One; 2012 Oct 9. 7 (10):e46585.

• Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

  Anne Stetler R, Leak R K, Yin W, Zhang L, Wang S, Gao Y and Chen J

  Journal of Neurochemistry. 2012 Oct 11; [Epub ahead of print].

• Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro

  Steketee M B, Moysidis S N, Weinstein J E, Kreymerman A, Silva J P, Iqbal S and Goldberg J L

  Invest Ophthalmol Vis Sci; 2012 Oct 30. 53 (11):7402-7411.

• Neuroprotective actions of methylene blue and its derivatives

  Poteet E, Winters A, Yan L J, Shufelt K, Green K N, Simpkins J W, Wen Y and Yang S H

  PLoS One; 2012 Oct 31. 7 (10):e48279.

• Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 premutation mouse model

  Kaplan E S, Cao Z, Hulsizer S, Tassone F, Berman R F, Hagerman P J and Pessah I N

  J Neurochem; 2012 Nov 1. 123 (4):613-21.

• Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/ref-1) is an indicator of energy disruption in neurons

  Singh S and Englander E W

  Free Radic Biol Med; 2012 Nov 1. 53 (9):1782-90.

• Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

  Zhao W, Varghese M, Vempati P, Dzhun A, Cheng A, Wang J, Lange D, Bilski A, Faravelli I and Pasinetti G M

  PLoS One; 2012 Nov 7. 7 (11):e49191.

• No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease

  Choi S W, Gerencser A A, Ng R, Flynn J M, Melov S, Danielson S R, Gibson B W, Nicholls D G, Bredesen D E and Brand M D

  J Neurosci; 2012 Nov 21. 32 (47):16775-16784.

• Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

  Xun Z, Rivera-Sanchez S, Ayala-Pena S, Lim J, Budworth H, Skoda E M, Robbins P D, Niedernhofer L J, Wipf P and McMurray C T

  Cell Rep; 2012 Nov 29. 2 (5):1137-42.

• Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells

  Lopert P, Day B J and Patel M

  PLoS One; 2012 Nov 30. 7 (11):e50683.

• Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

  Song L, Shan Y, Lloyd K C and Cortopassi G A

  Hum Mol Genet; 2012 Dec 1. 21 (23):5147-58.

• Alteration of Fatty-Acid-Metabolizing Enzymes Affects Mitochondrial Form and Function in Hereditary Spastic Paraplegia

  Tesson C, Nawara M, Salih M A, Rossignol R, Zaki M S, Al Balwi M, Schule R, Mignot C, Obre E, Bouhouche A, Santorelli F M, Durand C M, Oteyza A C, El-Hachimi K H, Al Drees A, Bouslam N, Lamari F, Elmalik S A, Kabiraj M M, Seidahmed M Z, Esteves T, Gaussen M, Monin M L, Gyapay G, Lechner D, Gonzalez M, Depienne C, Mochel F, Lavie J, Schols L, Lacombe D, Yahyaoui M, Al Abdulkareem I, Zuchner S, Yamashita A, Benomar A, Goizet C, Durr A, Gleeson J G, Darios F, Brice A and Stevanin G

  Am J Hum Genet; 2012 Dec 7. 91 (6):1051-64.

• Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse Extracellular Flux XF24 Analysis

  Lange M L, Zeng Y, Knight A, Windebank A and Trushina E

  Frontiers in Neurology; 2012 Dec 14. 3 (175)

• Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

  Brunetti D, Dusi S, Morbin M, Uggetti A, Moda F, D'Amato I, Giordano C, d'Amati G, Cozzi A, Levi S, Hayflick S and Tiranti V

  Hum Mol Genet; 2012 Dec 15. 21 (24):5294-305.

• Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo

  Miller D M, Singh I N, Wang J A and Hall E D

  Free Radic Biol Med; 2012 Dec 27. 57C (1)

• Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF

  Gouarne C, Giraudon-Paoli M, Seimandi M, Biscarrat C, Tardif G, Pruss R M and Bordet T

  Br J Pharmacol. 2012 Dec 28; [Epub ahead of print].

• Effect of Cholinergic Signaling on Neuronal Cell Bioenergetics

  Lu J, E L, Roy N, Hutfles L, Selfridge E, Funk E, Burns J M and Swerdlow R H

  J Alzheimers Dis; 2013 Jan 1. 33 (4):1135-46.

• Glycolysis-respiration relationships in a neuroblastoma cell line

  Swerdlow R H, Lezi E, Aires D and Lu J

  Biochim Biophys Acta; 2013 Jan 10. 1830 (4):2891-2898.

• Blocking c-jun-N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-hydroxydopamine-induced Toxicity in vitro and in vivo

  Chambers J W, Howard S and Lograsso P V

  J Biol Chem; 2013 Jan 11. 288 (2):1079-87.

• Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal

  Singh I N, Gilmer L K, Miller D M, Cebak J E, Wang J A and Hall E D

  J Cereb Blood Flow Metab. 2013 Jan 16; [Epub ahead of print].

• Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression

  Cronin-Furman E N, Borland M K, Bergquist K E, Bennett J P, Jr. and Trimmer P A

  Mol Neurodegener; 2013 Jan 26. 8 (1):6.

• Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death

  Perron N R, Beeson C and Rohrer B

  J Bioenerg Biomembr; 2013 Feb 1. 45 (1-2):101-9.

• Metabolism of 1-Methyl-4-phenyl-1-2-3-6-tetrahydropyridine by Mitochondria-targeted Cytochrome P450 2D6: Implications in Parkinson's Disease

  Bajpai P, Sangar M C, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang J K, Martin M V, Guengerich F P and Avadhani N G

  J Biol Chem; 2013 Feb 8. 288 (6):4436-51.

• Potentiation of brain mitochondrial function by S-equol and R/S-equol Estrogen Receptor beta selective phytoSERM treatments

  Yao J, Zhao L, Mao Z, Chen S, Wong K, To J and Brinton R D

  Brain Res. 2013 Feb 18; [Epub ahead of print].

• Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3

  Li L, Zhang J, Yang Y, Wang Q, Gao L, Chang T, Zhang X, Xiang G, Cao Y, Shi Z, Zhao M and Gao G

  Nanoscale Res Lett; 2013 Feb 22. 8 (1):100.

• Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

  Voloboueva L A, Emery J F, Sun X and Giffard R G

  FEBS Lett; 2013 Mar 18. 587 (6):756-62.

• The role of CSA and CSB protein in the oxidative stress response

  D'Errico M, Pascucci B, Lorio E, Van Houten B and Dogliotti E

  Mech Ageing Dev. 2013 Apr 3; [Epub ahead of print].

• Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells

  Im A R, Kim Y H, Uddin M R, Chae S, Lee H W, Kim Y S and Lee M Y

  Cell Mol Neurobiol. 2013 Apr 20; [Epub ahead of print].

Technical Posters

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• Effects of poly(ADP-ribose) polymerase-1 on mitochondrial function in cortical neuron cultures

  Kamboj A., Chowdhury S.K., Lu P., Fernyhough P., Anderson C.M.

  ISN/ASN Annual Meeting
  April 20-24, 2013
  Cancun, MX

• Amyloid-Beta Binding Alcohol Dehydrogenase (ABAD), Estradiol and Mitochondrial Dysfunction in Alzheimer's Disease

  A. Grimm, Y.-A. Lim, M. Giese, A.G. Mensah-Nyagan, J. Gatz, A. Eckert

  11th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2013)
  March 6-10, 2013
  Florence, IT

• Mitochondrial Biogenesis up-regulation in MCI and AD cybrids

  Silva DF, Selfridge JE, Lu J, E L, Cardoso SM, Swerdlow RH

  11th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2013)
  March 6-10, 2013
  Florence, IT

• A Natural H2S Donor Found in Garlic Attenuates Ischemia-Reperfusion Damage in Neurons by Protecting Mitochondrial Respiration

  Gloria A. Benavides, Qiuli Liang, Jianhua Zhang and Victor M. Darley-Usmar

  Society for Free Radical Biology and Medicine (SFRBM 2012)
  November 15-18, 2012
  San Diego, CA

• Decline in mitochondrial function after autophagic stress in a human Parkinson's disease cell model

  E.N. Cronin-Furman & P.A. Trimmer

  Neuroscience 2012
  October 14-17, 2012
  New Orleans, LA

• Role of the Ca2+ uniporter and the mitochondrial Ca2+-activated transporters of aspartate/glutamate (aralar/AGC1) and ATP-Mg/Pi (SCaMC-3) in agonist-stimulated respiration of intact cerebral cortex neurons

  Carlos B. Rueda, Irene Llorente-Folch, Javier Traba , Ignacio Amigo , Araceli del Arco, Beatriz Pardo, Jorgina Satrústegui

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• Evidence for Mitochondrial Dysfunction in Animal Models of Temporal Lobe Epilepsy

  Shane Rowley, Li-Ping Liang, Brian Day, Manisha Pa

  Gordon Research Conference on Mechanisms of Epilepsy & Neuronal Synchronization
  August 19-24, 2012
  Waterville Valley, NH

• Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: Lack of correlation with superoxide generation

  Brian P. Dranka, Jacek Zielonka, Anumantha G. Kanthasamy, and Balaraman Kalyanaraman

  Gordon Research Conference: Neurobiology of Brain Disorders - Synaptic Dysfunction and Neurodegeneration
  August 5-10, 2012
  Easton, MA

• Comparison of synaptosomal mitochondrial function and integrity in brain regions containing axon terminals of nigrostriatal and tuberoinfundibular dopamine neurons in parkin-deficient mice

  Hae-young Hawong , John L Goudreau, Keith Lookingland

  National MD/PhD Student Conference
  July 6-8, 2012
  Keystone, CO

• Mitochondrial impairment in patient fibroblasts from manifesting and non-manifesting LRRK2G2019S mutation carriers

  Heather Mortiboys, PhD, Krisztina K. Johansen, MD, Jan O. Aasly, MD, PhD, Oliver Bandmann, MD, PhD

  Mitochondrial Trafficking and Function in Neuronal Health and Disease
  June 25-26, 2012
  Boston, MA

• Reprogramming Mitochondrial Fuel Metabolism by BAD modulates neuronal excitability through the K-ATP channel

  A Gimenez-Cassina, JR Martinez-François, J Fisher, B Szlyk, K Polak, J Wiwczar, GR Tanner, A Lutas, G Yellen, NN Danial

  Keystone Symposia: Mitochondrial Dynamics and Function
  March 19-24, 2012
  Banff, Alberta, CA

• Impaired AMP-activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in DM

  Subir K. Roy Chowdhury, Dareell R. Smith, Jason, Schapansky, Ali Saleh, Suzanne Gomez, Eli Akude, Dwane Morrow, Nigel A. Calcutt and Paul Fernyhough

  Keystone symposia - Complications of Diabetes: Mechanisms of Injury and Failure of Repair
  March 11-16, 2012
  Boston, MA

• Pink1-deficient mice as a potential model to study common mechanisms of diabetes and neuronal dysfunction

  Ravi Akundi, Preetha Shridas, Lianteng Zhi, Wayne Cass, Kevin Pearson, Hansruedi Bueler

  American Society for Neurochemistry (ASN) Conference 2012
  March 3-7, 2012
  Baltimore, MD

• Mitochondrial inhibition and oxidant production differs between pharmacologic models of Parkinson's disease

  Brian P. Dranka, Jacek Zielonka, and B. Kalyanaraman

  Society for Free Radical Biology and Medicine (SFRBM) 2011
  November 16-20, 2011
  Atlanta, GA

• Inhibition of Thioredoxin Reductase potentiates paraquat-induced mitochondrial dysfunction and neurotoxicity in N27 dopaminergic cells

  Pamela Lopert and Manisha Patel

  Society for Free Radical Biology and Medicine (SFRBM) 2011
  November 16-20, 2011
  Atlanta, GA

• Reliable in vivo measurement of mitochondrial bioenergetics in animal models of temporal lobe epilepsy

  Shane Rowley and Manisha Patel

  Society for Free Radical Biology and Medicine (SFRBM) 2011
  November 16-20, 2011
  Atlanta, GA

• Partial dependence of rotenone toxicity on mitochondrial respiration: Effects of galactose versus glucose as energy sources

  April A. Dukes and Teresa G. Hastings

  Neuroscience 2011
  November 12, 2011
  Washington DC

• Assessment of caprylic triglyceride for dietary intervention in an amyotrophic lateral sclerosis mouse model

  M. VARGHESE, W. ZHAO, P. VEMPATI, A. CHENG, G. M. PASINETTI

  Neuroscience 2011
  November 12, 2011
  Washington DC

• Preclinical efficacy of 2-Deoxyglucose to sustain mitochondrial metabolic function and delay progression of Alzheimer's pathology

  Jia YAO, Shuhua Chen, ZisuMao, Fan Ding, Enrique Cadenas, Roberta Diaz BRINTON

  Neuroscience 2011
  November 12, 2011
  Washington DC

• Mutations in ATP13A2 impact on mitochondrial function and morphology

  B. Arns, P. Seibler, A. Rakovic, A. Ramirez, C. Sue, C. Klein, A. Grünewald

  84th Congress of the German Society of Neurology (DGN)
  September 28-1, 2011
  Wiesbaden, DE

• Stimulation of mitochondrial motility in hippocampal neurons improves neurite distribution and bioenergetic capacity

  A. Ferree, A. Newby-Kew, K. Tradeau, E. Zik, V. Levy, B. Wolozin, P. Lansbury, O. Shirihai

  Mitochondrial Dynamics: From Mechanism to Disease
  September 11-15, 2011
  Sardinia, IT

• SCaMC-3, The Brain and Liver Mitochondrial ATP-Mg/Pi Transporter, Prevents Mitochondrial Damage During Excitotoxicity Insults in vitro and in vivo by

  Rueda CB, Traba J, Amigo I, Pardo B, del Arco A, Satrustegui J

  Gordon Research Conference on Calcium Signalling
  June 26-1, 2011
  Waterville Valley, ME

• The Effects of Idebenone on Mitochondrial Bioenergetics

  Valentina Giorgio, Valeria Petronilli, Anna Ghelli, Valerio Carelli, Michela Rugolo & Paolo Bernardi

  Eighth European Meeting on Mitochondrial Pathology (EuroMIT8)
  June 20-23, 2011
  Zaragoza, Spain

• DNA damage precedes cell death in rotenone rat model of Parkinson's disease

  L.H. Sanders, P. G. Mastroberardino, V. Tapias, X. Hu, C.T. Chu, J.T. Greenamyre

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL, US

• Overexpression of the neuron-specific Drp1 isoform that includes exon 3 (ISO1) increases mitochondrial respiratory capacity in neurons

  C.A. Danilov, T. Uo, D.H. Margineantu, D. Hockenbery and R.S. Morrison

  Neuroscience 2010
  November 13-17, 2010
  San Diego, CA, US

• Neuronal bioenergetic reserves: Importance in Parkinson's disease

  Brian P. Dranka, Anumantha G. Kanthasamy, B. Kalyanaraman

  Neuroscience 2010
  November 13-17, 2010
  San Diego, CA, US

• DJ-1 knock-down impairs astrocyte mitochondrial function

  N.J. Larsen, G. Ambrosi, S.J. Mullett, S.B. Berman, D.A. Hinkle

  Neuroscience 2010
  November 13-17, 2010
  San Diego, CA, US

• Decreased Respiratory Capacity and Glycolytic Rates in a Rat Model of Temporal Lobe Epilepsy Revealed by Metabolic Flux Analysis of Hippocampal Synaptosomes

  Shane Rowley and Manisha Patel

  Neuroscience 2010
  November 13-17, 2010
  San Diego, CA, US

• Real-Time Monitoring of Mitochondrial and Cellular Bioenergetics in Cultured Neurons in a Microplate

  Amy L. Swift, Etienne Regulier, Younga Shin, Nagendra Yadava, David Nicholls, David A. Ferrick and Min Wu

  Neuroscience 2008: Society for Neuroscience 38th Annual Meeting
  November 15-19, 2008
  Washington, DC

Webinars

Sort by: Title | Speaker | Date
• 

  Programming the Mitochondrial Choice of Fuel Substrates: Metabolic Control of Neuronal Excitability

  Nika Danial, PhD, Dana-Farber Cancer Institute
  April 17, 2012

• 

  XF Glycolysis Stress Test Assesses Glycolysis and Glycolytic Capacity in Cells

  Min Wu, PhD, Seahorse Bioscience
  August 30, 2011

• 

  Adaptation of Microplate-based Respirometry for Hippocampal Brain Slices

  Brian Polster, PhD, University of Maryland Medical School
  May 12, 2011

• 

  Multidimensional control of mitochondrial energy production: learning from physiology and pathology

  Rodrigue Rossignol, PhD, Université de Bordeaux
  April 27, 2011

• 

  Spare Respiratory Capacity and the Bioenergetics of the Nerve Terminal

  David Nicholls, PhD, FRSE, Buck Institute for Age Research & Lund University
  December 3, 2009

• 

  Acute Brain Injury: Assessing Mitochondrial Dysfunction and the Role of Calpain Proteases in vitro

  Brian Polster, PhD, University of Maryland Medical School
  August 19, 2009

• 

  Oxidative Stress, Mitochondrial DNA Damage and Human Disease: How mitochondria repair their genome and how to measure mtDNA repair using quantitative PCR

  Ben Van Houten, PhD, University of Pittsburgh Cancer Institute
  May 21, 2009

• 

  Cybrid Modeling of Sporadic Neurodegenerative Disorders

  Russell H. Swerdlow, MD, University of Kansas School of Medicine
  March 16, 2009

• 

  Tutorial: Measuring Bioenergetics in a Variety of Cell Types

  David Ferrick, PhD, CSO, Seahorse Bioscience
  July 17, 2008

• 

  Bioenergetic Profiling in Translational Neuroscience

  Jon Nilsen, PhD, University of Southern California
  June 25, 2008

• 

  Quantifying the Mitochondrial Proton Circuit in Intact Cells - Volts and Amps

  David G. Nicholls, PhD, FRSE, Buck Institute for Age Research
  April 29, 2008

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