Applications in Model Organisms
Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)
PLoS One; 2009 Dec 17. 4 (12):e8329.
Development; 2010 Aug 1. 137 (15):2587-2596.
PLoS One; 2011 Sep 29. 6 (9):e25652.
Cell; 2011 Nov 11. 147 (4):827-839.
GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling
Hum Mol Genet; 2012 Mar 15. 21 (6):1248-59.
PLoS Genet; 2012 Apr 1. 8 (4):e1002645.
Expression Profiling of Attenuated Mitochondrial Function Identifies Retrograde Signals in Drosophila
G3: Genes|Genomes|Genetics; 2012 Aug 1. 2 (8):843-851.
PLoS Pathog; 2012 Oct 1. 8 (10):e1002996.
The impact of mitochondrial and thermal stress on the bioenergetics and reserve respiratory capacity of fish cell lines
J Aquat Anim Health; 2012 Dec 1. 24 (4):244-250.
PLoS One; 2013 Mar 14. 8 (3):e59218.
J Biol Chem.. 2013 Apr 3; [Epub ahead of print].
Models are those organisms with a wealth of biological data that make them attractive to study as examples for other species – including humans – that are more difficult to study directly. In the arena of drug discovery, model organisms provide an inexpensive and relatively quick means to perform two main functions: target identification and target validation. Together, these help show the value of any specific therapeutic strategies and drugs when attempting to reduce disease severity.
The XF Analyzer generates data that can provide new understanding in relation to model organisms and mitochondrial dysfunction, by allowing the measurement of cellular metabolism in real-time, in a microplate. By measuring the oxygen consumption rate (OCR) - a measure of mitochondrial respiration; as well as the extracellular acidification rate (ECAR) - a measure of glycolysis, you will be provided with the most physiologically relevant in vitro measurement for your bioenergetic studies.
- Cell Physiology
- Mitochondrial Diseases
- Model Organisms
- Obesity, Diabetes, & Metabolic Disorders
- Stem Cell Biology
- Toxicology & Hepatobiology
- Translational Medicine
Next Seahorse Webinar
Christian Frezza, PhD,
Hutchison/MRC Research Centre, Cambridge, UK
May 29, 2013
Advanced XF Training
Understanding When and How to Use Intact Cells and Isolated Mitochondria in Investigating Bioenergetics
XFe Extracellular Flux Analyzers
The world's most advanced cell metabolism analyzer.Learn More