Applications in Cell Physiology

App Notes & Tech Briefs

• Functional validation of Genomic and Proteomic data

  A platform to validate proteins and pathways that alter mitochondrial function

  Comparative genomic and proteomic analyses have identified approximately half of the estimated 1500 mitochondrial proteins encoded by the human nuclear genome. In recently published studies, XF assays have extended these estimates via the identification of functional roles of some of the nuclear and mtDNA-encoded proteins, and in one case, clarifying assumptions about their activity that had been based on sequence homology data...

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• Measuring mitochondrial respiration in intact skeletal muscle fibers

  Assessment of mitochondrial function in skeletal muscle is a powerful tool for modeling neuromuscular conditions including muscular dystrophy, aging and cachexia. Similarly, skeletal muscle plays an important role in normal and pathological metabolism, such as obesity and diabetes. The majority of investigations use measurements of single mitochondrial enzymes as a surrogate to measuring mitochondrial function which does not provide a complete physiological readout of the mitochondria...

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• Assessing mitochondrial dysfunction in primary cardiomyocytes

  Mitochondrial reserve capacity is a sensitive measure of cellular stress

  This Application Note describes a method for profiling mitochondrial function in cells responding to stress. The mitochondrial profile generated in this way provides four parameters of mitochondrial function that can be measured in one experiment...

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• Defining metabolic phenotypes in cancer cells

  Kinetic assay reveals the dynamic interplay of oxidative phosphorylation and glycolytic pathways

  Malignant transformation of cells is often characterized by aerobic glycolysis, the conversion of glucose into lactate, despite the presence of oxygen. This metabolic shift, known as the Warburg effect, [1] can occur as a result of the activation or mutation of oncogenes or tumor suppressor genes, or as an adaptive response to hypoxia...

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• Measuring glycolysis and oxidative metabolism in cancer cells

  Real-time assay enables scientists to connect metabolic pathways with oncogenic phenotypes

  Measuring the metabolic pathways in cancer cells, and their co-dependent or compensatory interplay, is important for understanding transformation mechanisms, mechanisms of malignant growth, cancer cell drug resistance, and for discovering potential drugs that are relatively specific for cancer cells...

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• Analyzing microgram quantities of isolated mitochondria in the XF24 Analyzer

  Enhanced appreciation of the role of altered mitochondrial function in tumorigenesis, aging, neurodegenerative, metabolic, and cardiovascular diseases has stimulated the development of a variety of new approaches for assessing mitochondrial function and dysfunction. As the field moves towards the discovery of mitochondrial-related, molecular mechanisms that underlie disease, and drugs to prevent or reverse disease development, the demand for higher throughput and more sensitive assay methods increases...

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Publications

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• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27 (2):433-446.

• Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

  Amo T, Yadava N, Oh R, Nicholls D G and Brand M D

  Gene; 2008 Mar 31. 411 (40545):69-76.

• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

  Wu N, Yin L, Hanniman E A, Joshi S and Lazar M A

  Genes Dev; 2009 Sep 15. 23 (18):2201-2209.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10 (4):273-284.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11 (3):213-219.

• Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

  Bao J, Lu Z, Joseph J J, Carabenciov D, Dimond C C, Pang L, Samsel L, McCoy J P, Jr., Leclerc J, Nguyen P, Gius D and Sack M N

  J Cell Biochem; 2010 May 1. 110 (1):238-247.

• Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

  Hawley S A, Ross F A, Chevtzoff C, Green K A, Evans A, Fogarty S, Towler M C, Brown L J, Ogunbayo O A, Evans A M and Hardie D G

  Cell Metab; 2010 Jun 9. 11 (6):554-565.

• Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

  Chinopoulos C, Gerencser A A, Mandi M, Mathe K, Torocsik B, Doczi J, Turiak L, Kiss G, Konrad C, Vajda S, Vereczki V, Oh R J and Adam-Vizi V

  FASEB J; 2010 Jul 1. 24 (7):2405-2416.

• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

  Chau M D, Gao J, Yang Q, Wu Z and Gromada J

  Proc Natl Acad Sci U S A; 2010 Jul 13. 107 (28):12553-12558.

• Wnt signaling regulates mitochondrial physiology and insulin sensitivity

  Yoon J C, Ng A, Kim B H, Bianco A, Xavier R J and Elledge S J

  Genes Dev; 2010 Jul 15. 24 (14):1507-1518.

• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria

  Cardenas C, Miller R A, Smith I, Bui T, Molgo J, Muller M, Vais H, Cheung K H, Yang J, Parker I, Thompson C B, Birnbaum M J, Hallows K R and Foskett J K

  Cell; 2010 Jul 23. 142 (2):270-283.

• Bioenergetic characterization of mouse podocytes

  Abe Y, Sakairi T, Kajiyama H, Shrivastav S, Beeson C and Kopp J B

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C464-476.

• Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

  Philp A, Perez-Schindler J, Green C, Hamilton D L and Baar K

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C240-250.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

  Qian W and Van Houten B

  Methods; 2010 Aug 1. 51 (4):452-457.

• MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

  Perocchi F, Gohil V M, Girgis H S, Bao X R, McCombs J E, Palmer A E and Mootha V K

  Nature; 2010 Sep 16. 467 (7313):291-296.

• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

  Nasrin N, Wu X, Fortier E, Feng Y, Bare O C, Chen S, Ren X, Wu Z, Streeper R S and Bordone L

  J Biol Chem; 2010 Oct 15. 285 (42):31995-32002.

• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

  Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro J B, Adelmant G O, Marto J A, Rhee K, Tisdale S, Danial N, Benarafa C, Orduna A and Anderson P

  Biochem Biophys Res Commun; 2010 Oct 22. 401 (3):440-446.

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

  Akhmedov D, Braun M, Mataki C, Park K S, Pozzan T, Schoonjans K, Rorsman P, Wollheim C B and Wiederkehr A

  FASEB J; 2010 Nov 1. 24 (11):4613-4626.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  Gurumurthy S, Xie S Z, Alagesan B, Kim J, Yusuf R Z, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park P J, Shirihai O S, Scadden D T and Bardeesy N

  Nature; 2010 Dec 2. 468 (7324):659-663.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

  Darshi M, Mendiola V L, Mackey M R, Murphy A N, Koller A, Perkins G A, Ellisman M H and Taylor S S

  J Biol Chem; 2011 Jan 28. 286 (4):2918-2932.

• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

• Exercise and PGC-1alpha-independent synchronization of type I muscle metabolism and vasculature by ERRgamma

  Narkar V A, Fan W, Downes M, Yu R T, Jonker J W, Alaynick W A, Banayo E, Karunasiri M S, Lorca S and Evans R M

  Cell Metab; 2011 Mar 2. 13 (3):283-293.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

  Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper R H, Schoonjans K, Schreiber V, Sauve A A, Menissier-de Murcia J and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):461-468.

• TEFM (c17orf42) is necessary for transcription of human mtDNA

  Minczuk M, He J, Duch A M, Ettema T J, Chlebowski A, Dzionek K, Nijtmans L G, Huynen M A and Holt I J

  Nucleic Acids Res; 2011 May 1. 39 (10):4284-4299.

• Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

  Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann C W, Schoonjans K, Pozzan T, Spat A and Wollheim C B

  Cell Metab; 2011 May 4. 13 (5):601-611.

• Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

  Chambers J W and Lograsso P V

  J Biol Chem; 2011 May 6. 286 (18):16052-16062.

• Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

  Bernier M, Paul R K, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He H J, Armour S M, Hubbard B P, Bohr V A, Wang L, Zong Y, Sinclair D A and de Cabo R

  J Biol Chem; 2011 Jun 3. 286 (22):19270-19279.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

  Baughman J M, Perocchi F, Girgis H S, Plovanich M, Belcher-Timme C A, Sancak Y, Bao X R, Strittmatter L, Goldberger O, Bogorad R L, Koteliansky V and Mootha V K

  Nature; 2011 Jun 19. 476 (7360):341-345.

• Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

  Mailloux R J, Dumouchel T, Aguer C, deKemp R, Beanlands R and Harper M E

  Biochem J; 2011 Jul 15. 437 (2):301-311.

• The Rate of Oxygen Utilization by Cells

  Wagner B A, Venkataraman S and Buettner G R

  Free Radical Biology and Medicine; 2011 Aug 1. 51 (3):700-712.

• PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

  Rorbach J, Nicholls T J and Minczuk M

  Nucleic Acids Res; 2011 Sep 1. 39 (17):7750-7763.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Uncoupling proteins and the control of mitochondrial reactive oxygen species production

  Mailloux R J and Harper M E

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.

• Apoptosis induced by persistent single-strand breaks in the mitochondrial genome: Critical role of EXOG (5' EXO/Endonuclease) in their repair

  Tann A W, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S and Szczesny B

  J Biol Chem; 2011 Sep 16. 286 (37):31975-31983.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• The PGC-1{alpha}-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

  Philp A, Belew M Y, Evans A, Pham D, Sivia I, Chen A, Schenk S and Baar K

  Am J Physiol Regul Integr Comp Physiol; 2011 Oct 1. 301 (4):R864-872.

• Molecular imaging of intracellular drug-membrane aggregate formation

  Baik J and Rosania G R

  Mol Pharm; 2011 Oct 3. 8 (5):1742-1749.

• Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B G, Zhang J, Landar A and Darley-Usmar V M

  Free Radic Biol Med; 2011 Nov 1. 51 (9):1621-1635.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

  Zhang J, Khvorostov I, Hong J S, Oktay Y, Vergnes L, Nuebel E, Wahjudi P N, Setoguchi K, Wang G, Do A, Jung H J, McCaffery J M, Kurland I J, Reue K, Lee W N, Koehler C M and Teitell M A

  EMBO J; 2011 Nov 15. 30 (24):4860-4873.

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

  Szanto M, Rutkai I, Hegedus C, Czikora A, Rozsahegyi M, Kiss B, Virag L, Gergely P, Toth A and Bai P

  Cardiovasc Res; 2011 Dec 1. 92 (3):430-438.

• Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

  Wang H, Sreenevasan U, Hu H, Saladino A, Polster B M, Lund L M, Gong D W, Stanley W C and Sztalryd C

  J Lipid Res; 2011 Dec 1. 52 (12):2159-2168.

• The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2

  Gan Z, Burkart-Hartman E M, Han D H, Finck B, Leone T C, Smith E Y, Ayala J E, Holloszy J and Kelly D P

  Genes Dev; 2011 Dec 15. 25 (24):2619-30.

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

  Yin F, Sancheti H and Cadenas E

  Biochim Biophys Acta; 2011 Dec 16. 1817 (3):401-409.

• Integrin-Dependent Akt1 Activation Regulates PGC-1 Expression and Fatty Acid Oxidation

  Beeson C C, Beeson G C, Buff H, Eldridge J, Zhang A, Seth A, Demcheva M, Vournakis J N and Muise-Helmericks R C

  J Vasc Res; 2012 Jan 13. 49 (2):89-100.

• Role of mitofusin 2 in the renal stress response

  Gall J M, Wang Z, Liesa M, Molina A, Havasi A, Schwartz J H, Shirihai O, Borkan S C and Bonegio R G

  PLoS One; 2012 Jan 26. 7 (1):e31074.

• SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

  Seifert E L, Caron A Z, Morin K, Coulombe J, Hong He X, Jardine K, Dewar-Darch D, Boekelheide K, Harper M E and McBurney M W

  FASEB J; 2012 Feb 1. 26 (2):555-66.

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol; 2012 Mar 1. 52 (3):701-10.

• Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

  Modis K, Gero D, Erdelyi K, Szoleczky P, Dewitt D and Szabo C

  Biochem Pharmacol; 2012 Mar 1. 83 (5):633-643.

• FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

  Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K and Nakao M

  Nat Commun; 2012 Mar 27. 3 (758)

• Correcting human mitochondrial mutations with targeted RNA import

  Wang G, Shimada E, Zhang J, Hong J S, Smith G M, Teitell M A and Koehler C M

  Proc Natl Acad Sci U S A; 2012 Mar 27. 109 (13):4840-4845.

• A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

  Kitami T, Logan D J, Negri J, Hasaka T, Tolliday N J, Carpenter A E, Spiegelman B M and Mootha V K

  PLoS One; 2012 Mar 29. 7 (3):e33755.

• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

  Higdon A N, Benavides G A, Chacko B K, Ouyang X, Johnson M S, Landar A, Zhang J and Darley-Usmar V M

  Am J Physiol Heart Circ Physiol; 2012 Apr 1. 302 (7):H1394-409.

• Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

  Xun Z, Lee D Y, Lim J, Canaria C A, Barnebey A, Yanonne S M and McMurray C T

  Mech Ageing Dev; 2012 Apr 1. 133 (4):176-85.

• Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

  Clerc P and Polster B M

  PLoS One; 2012 Apr 4. 7 (3):e34465.

• Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

  Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P C, Minor R K, Wilson Iii D M, Cooper M, Spencer R, de Cabo R, Croteau D L and Bohr V A

  J Exp Med; 2012 Apr 9. 209 (4):855-869.

• Chronic expression of RCAN1-1L induces mitochondrial autophagy and a metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells

  Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo A M and Davies K J

  J Biol Chem; 2012 Apr 20. 287 (17):14088-98.

• Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function

  Johnson A R, Lao S, Wang T, Galanko J A and Zeisel S H

  PLoS ONE; 2012 Apr 27. 7 (4):e36047.

• Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression

  Li J, Liu X, Wang H, Zhang W, Chan D C and Shi Y

  Proc Natl Acad Sci U S A; 2012 May 1. 109 (18):6975-80.

• C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome

  Rorbach J, Gammage P A and Minczuk M

  Nucleic Acids Res; 2012 May 1. 40 (9):4097-109.

• Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1

  Scott I, Webster B R, Li J H and Sack M N

  Biochem J; 2012 May 1. 443 (3):655-61.

• Additive effects of mitochondria-targeted Cytochrome P4502E1 and alcohol toxicity on cytochrome c oxidase function and the stability of respirosome complexes

  Bansal S, Srinivasan S, Anandasadagopan S, Roy Chowdhury A, Selvaraj V, Kalyanaraman B, Joseph J and Avadhani N G

  J Biol Chem; 2012 May 4. 287 (19):15284-97.

• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

  Hawley S A, Fullerton M D, Ross F A, Schertzer J D, Chevtzoff C, Walker K J, Peggie M W, Zibrova D, Green K A, Mustard K J, Kemp B E, Sakamoto K, Steinberg G R and Hardie D G

  Science; 2012 May 18. 336 (6083):918-22.

• Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

  Graves J A, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca M F, Elster J, Beer-Stolz D, Van Houten B, Vockley J and Prochownik E V

  PLoS One; 2012 May 21. 7 (5):e37699.

• Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1? and mitochondrial respiration

  Reiter C E N and Alayash A I

  FEBS Open Bio; 2012 May 24. 2 (2012):113-118.

• Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

  Fernandez-Marcos P J, Jeninga E H, Canto C, Harach T, de Boer V C, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten S M, Schoonjans K and Auwerx J

  Sci Rep; 2012 May 28. 2 (425)

• Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

  Aon M A, Stanley B A, Sivakumaran V, Kembro J M, O'Rourke B, Paolocci N and Cortassa S

  J Gen Physiol; 2012 Jun 1. 139 (6):479-91.

• RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

  Croteau D L, Rossi M L, Canugovi C, Tian J, Sykora P, Ramamoorthy M, Wang Z, Singh D K, Akbari M, Kasiviswanathan R, Copeland W C and Bohr V A

  Aging Cell; 2012 Jun 1. 11 (3):456-66.

• Peroxisome Proliferator-Activated Receptor gamma Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

  Hu S, Yao J, Howe A A, Menke B M, Sivitz W I, Spector A A and Norris A W

  Mol Endocrinol; 2012 Jun 1. 26 (6):977-988.

• p53 and Mitochondrial DNA: Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals

  Koczor C A, White R C, Zhao P, Zhu L, Fields E and Lewis W

  Am J Pathol; 2012 Jun 1. 180 (6):2276-2283.

• Cellular Responses to the Metal-Binding Properties of Metformin

  Logie L, Harthill J, Patel K, Bacon S, Hamilton D L, Macrae K, McDougall G, Wang H H, Xue L, Jiang H, Sakamoto K, Prescott A R and Rena G

  Diabetes; 2012 Jun 1. 61 (6):1423-33.

• An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

  Pascucci B, Lemma T, Iorio E, Giovannini S, Vaz B, Iavarone I, Calcagnile A, Narciso L, Degan P, Podo F, Roginskya V, Janjic B M, Van Houten B, Stefanini M, Dogliotti E and D'Errico M

  Aging Cell; 2012 Jun 1. 11 (3):520-29.

• Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

  Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon V P, Bixby J L, Gereben B and Bianco A C

  The Journal of Neuroscience; 2012 Jun 20. 32 (25):8491-8500.

• Adjustments of Mitochondrial Energy Transduction in Response to Physiological and Environmental Challenge

  Jastroch M., T. Ruf (Eds. C. Bieber, W. Arnold and E. Millesi )

  Living in a Seasonal World; 2012 Jul 1. Springer Berlin Heidelberg (2012, Part 3):387-398.

• Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms

  Sassi N, Biasutto L, Mattarei A, Carraro M, Giorgio V, Citta A, Bernardi P, Garbisa S, Szabo I, Paradisi C and Zoratti M

  Biochim Biophys Acta; 2012 Jul 1. 1817 (7):1095-106.

• Acyl-CoA thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

  Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck C K, Genoud C, Cron P, Keusch J J, Dummler B, Esposti M D and Hemmings B A

  Mol Cell Biol; 2012 Jul 1. 32 (14):2685-97.

• Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

  Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon C E, Zhang H, Neckers L and Pommier Y

  PLoS One; 2012 Jul 4. 7 (7):e41094.

• Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor YY1 in skeletal muscle

  Blättler S M, Verdeguer F, Liesa M, Cunningham J T, Vogel R O, Chim H, Liu H, Romanino K, Shirihai O S, Vazquez F, Rüegg M A, Shi Y and Puigserver P

  Mol Cell Biol; 2012 Aug 1. 32 (16):3333-46.

• Expression Profiling of Attenuated Mitochondrial Function Identifies Retrograde Signals in Drosophila

  Freije W A, Mandal S and Banerjee U

  G3: Genes|Genomes|Genetics; 2012 Aug 1. 2 (8):843-851.

• Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

  Furda A M, Marrangoni A M, Lokshin A and Van Houten B

  DNA Repair (Amst); 2012 Aug 1. 11 (8):684-92.

• Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase

  Mo L, Wang Y, Geary L, Corey C, Alef M J, Beer-Stolz D, Zuckerbraun B S and Shiva S

  Free Radic Biol Med; 2012 Aug 4. 53 (7):1440-1450.

• CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

  Kim SJ, Kwon MC, Ryu MJ, Chung HK, Tadi S, Kim YK, Man Kim J, Lee SH, Park JH, Kweon GR, Ryu SW, Jo YS, Lee CH, Hatakeyama H, Goto Y, Yim YH, Chung J, Kong YY, Shong M.

  Cell Metab; 2012 Aug 8. 16 (2):274-83.

• Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

  Siddiqui A, Chinta S J, Mallajosyula J K, Rajagopolan S, Hanson I, Rane A and Andersen J K

  Free Radical Biology and Medicine; 2012 Aug 15. 53 (4):993-1003.

• Bioenergetic Effects of Mitochondrial Targeted Coenzyme Q Analogs in Endothelial Cells

  Fink B D, Herlein J A, Yorek M A, Fenner A M, Kerns R J and Sivitz W I

  Journal of Pharmacology and Experimental Therapeutics; 2012 Sep 1. 342 (3):709-19.

• Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

  Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper R H, Auwerx J, Franken P and Tafti M

  J Neurosci; 2012 Sep 5. 32 (36):12506-12517.

• GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence

  Byun H O, Jung H J, Seo Y H, Lee Y K, Hwang S C, Seong Hwang E and Yoon G

  Exp Cell Res; 2012 Sep 10. 318 (15):1808-19.

• Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

  Mantel C, Messina-Graham S, Moh A, Cooper S, Hangoc G, Fu X Y and Broxmeyer H E

  Blood; 2012 Sep 27. 120 (13):2589-99.

• Role of TRIB3 in Regulation of Insulin Sensitivity and Nutrient Metabolism during Short-term Fasting and Nutrient Excess

  Liu J, Zhang W, Chuang G C, Hill H S, Tian L, Fu Y, Moellering D R and Garvey W T

  Am J Physiol Endocrinol Metab; 2012 Oct 1. 303 (7):E908-16.

• Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

  Sentelle R D, Senkal C E, Jiang W, Ponnusamy S, Gencer S, Panneer Selvam S, Ramshesh V K, Peterson Y K, Lemasters J J, Szulc Z M, Bielawski J and Ogretmen B

  Nat Chem Biol; 2012 Oct 1. 8 (10):831-8.

• Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species

  Hurd T R, Collins Y, Abakumova I, Chouchani E T, Baranowski B, Fearnley I M, Prime T A, Murphy M P and James A M

  J Biol Chem; 2012 Oct 12. 287 (42):35153-35160.

• Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

  Raichur S, Hooi Teh S, Ohwaki K, Gaur V, Chau Long Y, Hargreaves M, McGee S L and Kusunoki J

  J Mol Endocrinol; 2012 Oct 12. 49 (3):203-211.

• MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake that Regulates Cell Survival

  Mallilankaraman K, Doonan P, Cardenas C, Chandramoorthy H C, Muller M, Miller R, Hoffman N E, Gandhirajan R K, Molgo J, Birnbaum M J, Rothberg B S, Mak D O, Foskett J K and Madesh M

  Cell; 2012 Oct 26. 151 (3):630-644.

• Integration of cellular bioenergetics with mitochondrial quality control and autophagy

  Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M

  Biol Chem; 2012 Nov 1. 393 (12):1485-1512.

• MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism

  Mallilankaraman K, Cardenas C, Doonan P J, Chandramoorthy H C, Irrinki K M, Golenar T, Csordas G, Madireddi P, Yang J, Muller M, Miller R, Kolesar J E, Molgo J, Kaufman B, Hajnoczky G, Foskett J K and Madesh M

  Nat Cell Biol; 2012 Dec 1. 14 (12):1336-1343.

• Mitochondrial hyperfusion induced by loss of fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

  Qian W, Choi S, Gibson G A, Watkins S C, Bakkenist C J and Houten B V

  J Cell Sci; 2012 Dec 1. 125 (Pt 23):5745-57.

• Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions

  Zhang C, Huang V H, Simon M, Sharma L K, Fan W, Haas R, Wallace D C, Bai Y and Huang T

  FASEB J; 2012 Dec 1. 26 (12):4914-4924.

• SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC1alpha

  Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh E T and Cheng J

  J Biol Chem; 2012 Dec 28. 287 (53):44464-70.

• Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

  Lin H Y, Lai R H, Lin S T, Lin R C, Wang M J, Lin C C, Lee H C, Wang F F and Chen J Y

  Cell Death Differ; 2013 Jan 1. 20 (1):139-53.

• Mitochondrially targeted compounds and their impact on cellular bioenergetics

  Reily C, Mitchell T, Chacko B K, Benavides G A, Murphy M P and Darley-Usmar V M

  Redox Biology; 2013 Jan 1. 1 (1):86-93.

• Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells

  Diers A R, Broniowska K A and Hogg N

  Redox Biology; 2013 Jan 7. 1 (1):1-7.

• Integrating Mitochondrial Energetics, Redox and ROS Metabolic Networks: A Two-Compartment Model

  Kembro Jackelyn M, Aon Miguel A, Winslow Raimond L, O’Rourke B and Cortassa S

  Biophysical Journal. 2013 Jan 22; [Epub ahead of print].

• Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+-activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3

  Amigo I, Traba J, Gonzalez-Barroso M M, Rueda C B, Fernandez M, Rial E, Sanchez A, Satrustegui J and Del Arco A

  J Biol Chem. 2013 Jan 23; [Epub ahead of print].

• Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

  Rensvold Jarred W, Ong S-E, Jeevananthan A, Carr Steven A, Mootha Vamsi K and Pagliarini David J

  Cell Reports; 2013 Jan 31. 3 (1):237-45.

• Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

  Modis K, Coletta C, Erdelyi K, Papapetropoulos A and Szabo C

  FASEB J; 2013 Feb 1. 27 (2):601-611.

• Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1

  Rafikov R, Rafikova O, Aggarwal S, Gross C, Sun X, Desai J, Fulton D and Black S M

  J Biol Chem; 2013 Mar 1. 288 (9):6212-6226.

• alpha-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKalpha in vitro

  Wang L and Brautigan D L

  Nat Commun; 2013 Mar 7. 4 (1559)

• Mitochondrial matrix P53 sensitizes cells to oxidative stress

  Koczor C A, Torres R A, Fields E J, Boyd A and Lewis W

  Mitochondrion; 2013 Mar 14. 13 (14):277-281.

• Glutaredoxin-2 Is Required to Control Proton Leak through Uncoupling Protein-3

  Mailloux R J, Xuan J Y, Beauchamp B, Jui L, Lou M and Harper M E

  J Biol Chem; 2013 Mar 22. 288 (12):8365-8379.

• Characterization of transgenic Gfrp knock-in mice: Implications for tetrahydrobiopterin in modulation of normal tissue radiation responses

  Pathak R, Pawar S, Fu Q, Gupta P K, Berbee M, Garg S, Sridharn V, Wang W, Prabath B, Krager K, Boerma M, Ghosh S, Cheema A, Hendrickson H, Aykin-Burns N and Hauer-Jensen M

  Antioxid Redox Signal. 2013 Mar 23; [Epub ahead of print].

• Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

  Modis K, Asimakopoulou A, Coletta C, Papapetropoulos A and Szabo C

  Biochem Biophys Res Commun. 2013 Mar 26; [Epub ahead of print].

• Global analysis of SUMO chain function reveals multiple roles in chromatin regulation

  Srikumar T, Lewicki M C, Costanzo M, Tkach J M, van Bakel H, Tsui K, Johnson E S, Brown G W, Andrews B J, Boone C, Giaever G, Nislow C and Raught B

  J Cell Biol; 2013 Apr 1. 201 (1):145-163.

• Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress

  Sun Q, Gao W, Loughran P, Shapiro R, Fan J, Billiar T R and Scott M J

  J Biol Chem. 2013 Apr 15; [Epub ahead of print].

• The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

  Anedda A, Lopez-Bernardo E, Acosta-Iborra B, Saadeh Suleiman M, Landazuri M O and Cadenas S

  Free Radic Biol Med. 2013 Apr 16; [Epub ahead of print].

• The role of p38 in mitochondrial respiration in male and female mice

  Ju X, Wen Y, Metzger D and Jung M

  Neurosci Lett. 2013 Apr 17; [Epub ahead of print].

• MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein

  Han K S and Ayer D E

  Biochem J. 2013 May 1; [Epub ahead of print].

• A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

  McQuaker S J, Quinlan C L, Caldwell S T, Brand M D and Hartley R C

  Chembiochem. 2013 May 2; [Epub ahead of print].

• Lacritin rescues stressed epithelia via rapid FOXO3 associated autophagy that restores metabolism

  Wang N, Zimmerman K, Raab R W, McKown R L, Hutnik C M, Talla V, Tyler M F, Lee J K and Laurie G W

  J Biol Chem. 2013 May 2; [Epub ahead of print].

• Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

  Lopez-Erauskin J, Galino J, Ruiz M, Cuezva J M, Fabregat I, Cacabelos D, Boada J, Martinez J, Ferrer I, Pamplona R, Villarroya F, Portero-Otin M, Fourcade S and Pujol A

  Human molecular genetics; 2013 May 3.

• WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

  Esen E, Chen J, Karner C M, Okunade A L, Patterson B W and Long F

  Cell metabolism; 2013 May 7. 14 (5):745-55.

Technical Posters

Sort by: Title | Author | Date

• New regulatory role of miR-125b/BIK axis on mitochondria functions in monocytes: a link between apoptosis and autophagy

  Duroux-Richard I, Roubert C, Ammari M, Prasumey J, Grun JR, Grutzkau A, Hupl T, Lecellier C-H, Jorgensen C, Apparailly F

  Ninth Annual microRNA: Targets & Tools for Therapeutic Development
  March 4-5, 2013
  Cambridge, MA

• Metabolic rates of cultured skeletal muscle from Coturnix quail selected for different rates of growth

  Clara Cooper-Mullin, Ana Jimenez and Joseph B. Williams

  The Society for Integrative & Comparative Biology Annual Meeting
  January 3-7, 2013
  San Francisco, CA

• Cells of tropical birds contribute to their slow pace of life

  Ana G. Jimenez and Joseph B. Williams

  The Society for Integrative & Comparative Biology Annual Meeting
  January 3-7, 2013
  San Francisco, CA

• The effect of resveratrol on mitochondria function in whole cells

  Anne L. Widlund, Ole Vang and Louise T. Dalgaard

  2nd International Scientific Conference on Resveratrol and Health
  December 5-7, 2012
  Leicester, UK

• Mitochondrial Dysfunction in a Rat Model of Chronic Migraine

  Nathan T. Fried, Cynthia Moffat, Erin Seifert, Michael L. Oshinsky

  Neuroscience 2012
  October 14-17, 2012
  New Orleans, LA

• UCP2 in tumour cells: Analyzing its role in the defence against oxidative stress

  Jessica Segales, Aleida Pujol, Carlos Sanchez-Martan and Eduardo Rial

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

  Ajit S. Divakaruni, Sandra E. Wiley, George W. Rogers, Jerry R. Colca, Melvin I. Simon, Theodore P. Ciaraldi, Anne N. Murphy

  European Bioenergetic Conference (EBEC 2012)
  September 15-20, 2012
  Freiberg, DE

• The role of SCaMC-3, the mitochondrial transporter of ATP-Mg/Pi expressed in liver, in regulating OXPHOS

  I. Amigo, J. Traba, MM Gonzalez-Barroso, C. Rueda, M. Fernandez, E. Rial, A. Sanchez, J. Satrustegui, A. del Arco

  22nd IUBMB & 37th FEBS Congress
  September 4-9, 2012
  Seville, ES

• Bioenergetics in Leghorn Male Hepatoma Cells and Immortalized Chicken Liver Cells in Response to 4-Hydroxynonenal-induced Oxidative Stress

  Alissa Piekarski

  Poultry Science Association Annual Meeting
  July 9-12, 2012
  Athens, GA

• Cooperative Interactions of H2S and Krebs Cycle-Derived Electron Donors: Maintenance of Mitochondrial Electron Transport and Cellular Bioenergetics

  Katalin Modis, Ciro Coletta, Andreas Papapetropoulos and Csaba Szabo

  First European Concerence on the Biology of Hydrogen Sulfide
  June 15-18, 2012
  Smolenice, Slovakia

• Retinoic acid induces a metabolic switch in SH-SY5Y cells from glycolysis to oxidative

  Zhiyin Xun, Do-Yup Lee, James Lim, Christie A. Canaria, Adam Barnebey, Steven M. Yanonne and Cynthia T. McMurray

  The American Society for Biochemistry and Molecular Biology Annual Meeting (ASBMB)
  April 21-25, 2012
  San Diego, CA

• Role of miR-210 in hypoxia induced mitochondrial dysfunction in placenta with preeclampsia

  Muralimanoharan S, Maloyan A, Mele J, Myatt L and L

  Society for Gynecological Investigation (SGI) 2012
  March 21-24, 2012
  San Diego, CA

• Adenine and pyridine nucleotide depletion by nitric oxide and superoxide in endothelial cells. Implications for bioenergetic dysfunction and cell death

  Katarzyna A. Broniowska, Anne R. Diers, John A. Corbett, and Neil Hogg

  Gordon Research Conferences: Oxygen Radicals
  February 5-10, 2012
  Ventura, CA

• S-Nitrosation of Monocarboxylate Transporter 4: inhibition of pyruvate-fueled mitochondrial respiration and proliferation of breast cancer cells

  Anne R. Diers, Katarzyna A. Broniowska, Ching-Fang Chang, Neil Hogg

  Gordon Research Conferences: Oxygen Radicals
  February 5-10, 2012
  Ventura, CA

• TAp63 Controls Energy Metabolism through Transcriptional Active SIRT1 and AMPKalpha

  Xiaohua Su

  The 5th International p63/p73 Workshop
  November 13, 2011
  Lyon, FR

• MTCH2/MIMP: A novel regulator of liver apoptosis and metabolism

  Yehudit Zaltsman, Liat Shachnai and Atan Gross

  Cold Spring Harbor Laboratory Cell Death
  October 11-15, 2011
  Cold Spring Harbor, NY

• Towards a novel methodology to simultaneously measure the Krebs cycle and Electron Transport Chain activity using the Seahorse XF24 Analyzer

  Marc Liesa, George W. Rogers, Sam Sereda, David Ferrick, Orian Shirihai

  Mitochondrial Physiology and Medicine
  September 7-11, 2011
  Woods Hole, MA

• Choline dehydrogenase is necessary for normal energy metabolism in mouse sperm

  Amy R. Johnson and Steven H. Zeisel

  Experimental Biology 2011
  April 9-13, 2011
  Washington, DC, US

• Quantitative Proteomics and Functional Consequences of Mitochondrial Protein Carbonylation

  JESSICA CURTIS, MATT STONE, WENDY HAHN, JACOB INDA, TIMOTHY GRIFFIN, AND DAVID BERNLOHR

  Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  January 13-15, 2011
  Keystone, CO, US

• Assessing mitochondrial and cellular bioenergetics in human pluripotent stem cells

  Alessandro Prigione and James Adjay

  Targeting Mitochondria 2010
  November 18-19, 2010
  Berlin, DE

• Cellular Bioenergetics in Chicken Embryo FibroBlast (CEF) and Immortal CEF (DF-1) Cells

  K. Lassiter, J. Y. Lee, A. Piekarski , B-W. Kong, J. J. Song, and W. Bottje

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL, US

• Reduction of mitochondrial reserve capacity in endothelial cells by nitric oxide and superoxide: detection and quantitation of peroxynitrite formed from co-generated NO and O2

  Jacek Zielonka, Brian P. Dranka, Monika Zielonka, Joy Joseph, Micael Hardy, Adam Sikora, and B. Kalyanaraman

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL, US

• Abrupt Alcohol Withdrawal suppresses Mitochondrial Repiration in an Estrogen Preventable Manner

  Xiaohua Ju, Daniel Metzger, Yi Wen, Shaohua Yang, James W. Simpkins and Marianna Jung

  Neuroscience 2010
  November 13-17, 2010
  San Diego, CA, US

• The Homeobox Protein Prox1 is a Negative Modulator of ERR[Alpha]/PGC-1[Alpha] Bioenergetic Functions

  Alexis Charest-Marcotte, Catherine R. Dufour, Brian J. Wilson, Annie M. Tremblay, Lillian J. Eichner, Daniel H. Arlow, Vamsi K. Mootha and Vincent Gigu

  Nuclear Receptors: Development, Physiology and Disease
  March 21-26, 2010
  Keystone, CO, US

Webinars

Sort by: Title | Speaker | Date
• 

  Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Brian P. Dranka, PhD, Medical College of Wisconsin
  March 27, 2012

• 

  Adaptation of Microplate-based Respirometry for Hippocampal Brain Slices

  Brian Polster, PhD, University of Maryland Medical School
  May 12, 2011

• 

  Multidimensional control of mitochondrial energy production: learning from physiology and pathology

  Rodrigue Rossignol, PhD, Université de Bordeaux
  April 27, 2011

• 

  Profiling Mitochondrial Function has never been so Easy: A Tutorial on the New XF Mito Stress Test Kit

  David Ferrick, PhD, CSO, Seahorse Bioscience
  September 1, 2010

• 

  Mitochondrial Profiling in Cells Under Physiological Conditions and In Response to Stress

  Victor Darley-Usmar, PhD, University of Alabama at Birmingham
  August 4, 2010

• 

  Turbocharging your Mitochondrial Analysis: A Tutorial that Goes Beyond the Obvious

  Min Wu, PhD, Assay Development, Seahorse Bioscience
  David Ferrick, PhD, CSO, Seahorse Bioscience
  February 24, 2010

• 

  Importance of the Mitochondrial Reserve Capacity in Cardiovascular Cells Exposed to Oxidative Stress.

  Brad Hill, PhD, Center for Diabetes and Obesity Research, University of Louisville
  January 20, 2010

• 

  Spare Respiratory Capacity and the Bioenergetics of the Nerve Terminal

  David Nicholls, PhD, FRSE, Buck Institute for Age Research & Lund University
  December 3, 2009

• 

  Fluorescent Reporters of Mitochondrial Function in the Life and Death of Cells

  John J. LeMasters, MD, PhD, Medical University of South Carolina
  February 18, 2009

• 

  The Rate and Coupling Efficiency of Oxidative Phosphorylation in Mitochondria and Cells

  Martin Brand, PhD, Buck Institute, MRC Dunn Human Nutrition Unit
  December 8, 2008

• 

  The Response of the Mitochondrion to Oxidative Stress in Cardiovascular Cells

  Victor Darley-Usmar, PhD, University of Alabama at Birmingham
  November 11, 2008

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