Applications in Aging
App Notes & Tech Briefs
A sensitive and robust cell-based screening assay.
Mitochondrial damage compromises ATP production and consequentially cellular viability. Given the central role that mitochondria play in regulating cellular function, drugs that undermine mitochondrial function frequently elicit toxic effects...Learn More
Am J Physiol Regul Integr Comp Physiol; 2013 Feb 1.
J Gerontol A Biol Sci Med Sci; 2012 Oct 1. 67 (10):1022-35.
GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence
Exp Cell Res; 2012 Sep 10. 318 (15):1808-19.
ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome
Neurobiol Aging; 2012 Aug 1. 33 (8):1843.e.1-7.
Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan
International Journal of Gerontology; 2012 Jun 8. 6 (2):122-126.
Cell Stem Cell; 2012 May 4. 10 (5):515-519.
Cell Cycle; 2012 Apr 1. 11 (7):1383-1392.
Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.
Cell; 2012 Feb 3. 148 (3):421-433.
Genes Dev; 2011 Dec 15. 25 (24):2579-2593.
Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.
J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.
J Neurosci; 2011 Mar 23. 31 (12):4524-4534.
Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts
Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL
Cell Metab; 2010 May 5. 11 (5):412-426.
Nature; 2009 May 21. 459 (7245):387-392.
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
Aging (Albany NY); 2009 Apr 1. 1 (4):425-437.
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy
Aging and Diseases of Aging (S2), Keystone symposium
October 22-27, 2012
Long term culture of lung fibroblasts is accompanied by increased doubling time, mitochondrial hyperfusion, and altered oxygen consumption prior to the...
Mitochondria and Metabolism
June 12-14, 2012
Mitochondrial ribosomal proteins regulate longevity in three species through the mitochondrial unfolded protein response
Keystone Symposia: Mitochondrial Dynamics and Function
March 19-24, 2012
Banff, Alberta, CA
The Homeobox Protein Prox1 is a Negative Modulator of ERR[Alpha]/PGC-1[Alpha] Bioenergetic Functions
Nuclear Receptors: Development, Physiology and Disease
March 21-26, 2010
Keystone, CO, US
Testing modulators of uncoupling protein (UCP) function in intact HEK293 cells using plate-based respirometry and membrane potential sensitive fluorescent probes
Molecular & Cellular Bioenergetics Gordon Research Conference
June 10, 2009
Laurent Mouchiroud, PhD , École Polytechnique Fédérale de Lausanne
Riekelt H. Houtkooper, PhD, École Polytechnique Fédérale de Lausanne
November 30, 2011
David Nicholls, PhD, FRSE, Buck Institute for Age Research & Lund University
December 3, 2009
The Bioenergetics of Obesity: New Approaches to Characterize Genes Affecting Energy Balance in Mouse Models
Karen Reue, PhD, David Geffen School of Medicine at UCLA
April 30, 2009
Victor Darley-Usmar, PhD, University of Alabama at Birmingham
November 11, 2008
Antonio C. Bianco, MD, PhD, Brigham and Women’s Hospital & Harvard Medical School
March 25, 2008
Orian Shirihai, MD, PhD , Tufts University School of Medicine
January 30, 2008
Mitochondrial dysfunction is of central concern in the ageing process. Increasing age correlates with an accumulation of oxidative damage and somatic mitochondrial DNA (mtDNA) mutations and a decline in oxidative phosphorylation.
The XF Analyzer generates data that can provide new understanding in relation to aging and mitochondrial dysfunction, by allowing the measurement of cellular metabolism in real-time, in a microplate. By measuring the oxygen consumption rate (OCR) - a measure of mitochondrial respiration; as well as the extracellular acidification rate (ECAR) - a measure of glycolysis, you will be provided with the most physiologically relevant in vitro measurement for your bioenergetic studies.
- Cell Physiology
- Mitochondrial Diseases
- Model Organisms
- Obesity, Diabetes, & Metabolic Disorders
- Stem Cell Biology
- Toxicology & Hepatobiology
- Translational Medicine
Next Seahorse Webinar
Christian Frezza, PhD,
Hutchison/MRC Research Centre, Cambridge, UK
May 29, 2013
Advanced XF Training
Understanding When and How to Use Intact Cells and Isolated Mitochondria in Investigating Bioenergetics
XFe Extracellular Flux Analyzers
The world's most advanced cell metabolism analyzer.Learn More